{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:34Z","timestamp":1791400594997,"version":"4.3.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, we have demonstrated that concurrent hypothermia and mesenchymal stem cells (MSCs) transplantation synergistically improved severe neonatal hypoxic ischemic encephalopathy (HIE). The current study was designed to determine whether hypothermia could extend the therapeutic time window of MSC transplantation for severe neonatal HIE. To induce HIE, newborn rat pups were exposed to 8% oxygen for 2\u2009h following unilateral carotid artery ligation on postnatal day (P) 7. After approving severe HIE involving &gt;50% of the ipsilateral hemisphere volume, hypothermia (32\u2009\u00b0C) for 2 days was started. MSCs were transplanted 2 days after HIE modeling. Follow-up brain MRI, sensorimotor function tests, assessment of inflammatory cytokines in the cerebrospinal fluid (CSF), and histological evaluation of peri-infarction area were performed. HIE induced progressively increasing brain infarction area over time, increased cell death, reactive gliosis and brain inflammation, and impaired sensorimotor function. All these damages observed in severe HIE showed better, robust improvement with a combination treatment of hypothermia and delayed MSC transplantation than with either stand-alone therapy. Hypothermia itself did not significantly reduce brain injury, but broadened the therapeutic time window of MSC transplantation for severe newborn HIE.<\/jats:p>","DOI":"10.1038\/s41598-018-25902-x","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T11:27:17Z","timestamp":1525951637000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Hypothermia broadens the therapeutic time window of mesenchymal stem cell transplantation for severe neonatal hypoxic ischemic encephalopathy"],"prefix":"10.1038","volume":"8","author":[{"given":"So Yoon","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Sil","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kyung","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se In","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"25902_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0387-7604(96)00561-X","volume":"19","author":"MV Johnston","year":"1997","unstructured":"Johnston, M. V. Hypoxic and ischemic disorders of infants and children. Lecture for 38th meeting of Japanese Society of Child Neurology, Tokyo, Japan, July 1996. Brain & development 19, 235\u2013239 (1997).","journal-title":"Brain & development"},{"key":"25902_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1469-8749.1985.tb04571.x","volume":"27","author":"C Robertson","year":"1985","unstructured":"Robertson, C. & Finer, N. Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years. Dev Med Child Neurol 27, 473\u2013484 (1985).","journal-title":"Dev Med Child Neurol"},{"key":"25902_CR3","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1161\/STROKEAHA.108.514471","volume":"39","author":"M Yenari","year":"2008","unstructured":"Yenari, M., Kitagawa, K., Lyden, P. & Perez-Pinzon, M. Metabolic downregulation: a key to successful neuroprotection? Stroke; a journal of cerebral circulation 39, 2910\u20132917, https:\/\/doi.org\/10.1161\/STROKEAHA.108.514471 (2008).","journal-title":"Stroke; a journal of cerebral circulation"},{"key":"25902_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003311.pub2","author":"S Jacobs","year":"2007","unstructured":"Jacobs, S., Hunt, R., Tarnow-Mordi, W., Inder, T. & Davis, P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev, CD003311. https:\/\/doi.org\/10.1002\/14651858.CD003311.pub2 (2007).","journal-title":"Cochrane Database Syst Rev, CD003311"},{"key":"25902_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1542\/peds.110.2.377","volume":"110","author":"S Shankaran","year":"2002","unstructured":"Shankaran, S. et al. Whole-Body Hypothermia for Neonatal Encephalopathy: Animal Observations as a Basis for a Randomized, Controlled Pilot Study in Term Infants. Pediatrics 110, 377\u2013385 (2002).","journal-title":"Pediatrics"},{"key":"25902_CR6","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","volume":"361","author":"DV Azzopardi","year":"2009","unstructured":"Azzopardi, D. V. et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. The New England journal of medicine 361, 1349\u20131358, https:\/\/doi.org\/10.1056\/NEJMoa0900854 (2009).","journal-title":"The New England journal of medicine"},{"key":"25902_CR7","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. The New England journal of medicine 353, 1574\u20131584, https:\/\/doi.org\/10.1056\/NEJMcps050929 (2005).","journal-title":"The New England journal of medicine"},{"key":"25902_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3727\/096368916X692861","volume":"26","author":"SY Ahn","year":"2017","unstructured":"Ahn, S. Y. et al. Pivotal Role of Brain-Derived Neurotrophic Factor Secreted by Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage in Newborn Rats. Cell Transplant 26, 145\u2013156, https:\/\/doi.org\/10.3727\/096368916X692861 (2017).","journal-title":"Cell Transplant"},{"key":"25902_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/pr.2012.71","volume":"72","author":"ES Kim","year":"2012","unstructured":"Kim, E. S. et al. Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. Pediatric research 72, 277\u2013284, https:\/\/doi.org\/10.1038\/pr.2012.71 (2012).","journal-title":"Pediatric research"},{"key":"25902_CR10","doi-asserted-by":"publisher","first-page":"e51253","DOI":"10.1371\/journal.pone.0051253","volume":"8","author":"V Donega","year":"2013","unstructured":"Donega, V. et al. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement. PloS one 8, e51253, https:\/\/doi.org\/10.1371\/journal.pone.0051253 (2013).","journal-title":"PloS one"},{"key":"25902_CR11","doi-asserted-by":"publisher","first-page":"9603","DOI":"10.1523\/JNEUROSCI.1835-10.2010","volume":"30","author":"CT van Velthoven","year":"2010","unstructured":"van Velthoven, C. T., Kavelaars, A., van Bel, F. & Heijnen, C. J. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. The Journal of neuroscience: the official journal of the Society for Neuroscience 30, 9603\u20139611, https:\/\/doi.org\/10.1523\/JNEUROSCI.1835-10.2010 (2010).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"25902_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.bbi.2009.10.017","volume":"24","author":"CT van Velthoven","year":"2010","unstructured":"van Velthoven, C. T., Kavelaars, A., van Bel, F. & Heijnen, C. J. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain, behavior, and immunity 24, 387\u2013393, https:\/\/doi.org\/10.1016\/j.bbi.2009.10.017 (2010).","journal-title":"Brain, behavior, and immunity"},{"key":"25902_CR13","doi-asserted-by":"publisher","first-page":"e0120893","DOI":"10.1371\/journal.pone.0120893","volume":"10","author":"WS Park","year":"2015","unstructured":"Park, W. S. et al. Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy. PloS one 10, e0120893, https:\/\/doi.org\/10.1371\/journal.pone.0120893 (2015).","journal-title":"PloS one"},{"key":"25902_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1161\/STROKEAHA.112.679092","volume":"44","author":"SY Ahn","year":"2013","unstructured":"Ahn, S. Y. et al. Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage. Stroke; a journal of cerebral circulation 44, 497\u2013504, https:\/\/doi.org\/10.1161\/STROKEAHA.112.679092 (2013).","journal-title":"Stroke; a journal of cerebral circulation"},{"key":"25902_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0033-1363276","volume":"226","author":"L Gortner","year":"2014","unstructured":"Gortner, L. Therapeutic hypothermia in neonatal asphyxia. Klin Padiatr 226, 1\u20132, https:\/\/doi.org\/10.1055\/s-0033-1363276 (2014).","journal-title":"Klin Padiatr"},{"key":"25902_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000444905","volume":"109","author":"SY Ahn","year":"2016","unstructured":"Ahn, S. Y., Chang, Y. S. & Park, W. S. Stem Cells for Neonatal Brain Disorders. Neonatology 109, 377\u2013383, https:\/\/doi.org\/10.1159\/000444905 (2016).","journal-title":"Neonatology"},{"key":"25902_CR17","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.jpeds.2013.12.011","volume":"164","author":"YS Chang","year":"2014","unstructured":"Chang, Y. S. et al. Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial. The Journal of pediatrics 164, 966\u2013972 e966, https:\/\/doi.org\/10.1016\/j.jpeds.2013.12.011 (2014).","journal-title":"The Journal of pediatrics"},{"key":"25902_CR18","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","volume":"164","author":"CM Cotten","year":"2014","unstructured":"Cotten, C. M. et al. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. The Journal of pediatrics 164, 973\u2013979 e971, https:\/\/doi.org\/10.1016\/j.jpeds.2013.11.036 (2014).","journal-title":"The Journal of pediatrics"},{"key":"25902_CR19","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1542\/peds.2005-1649","volume":"117","author":"FE O\u2019Brien","year":"2006","unstructured":"O\u2019Brien, F. E. et al. Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 117, 1549\u20131559, https:\/\/doi.org\/10.1542\/peds.2005-1649 (2006).","journal-title":"Pediatrics"},{"key":"25902_CR20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/00004647-200003000-00010","volume":"20","author":"J Guan","year":"2000","unstructured":"Guan, J. et al. The window of opportunity for neuronal rescue with insulin-like growth factor-1 after hypoxia-ischemia in rats is critically modulated by cerebral temperature during recovery. J Cereb Blood Flow Metab 20, 513\u2013519, https:\/\/doi.org\/10.1097\/00004647-200003000-00010 (2000).","journal-title":"J Cereb Blood Flow Metab"},{"key":"25902_CR21","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/jcbfm.1995.122","volume":"15","author":"WD Dietrich","year":"1995","unstructured":"Dietrich, W. D. et al. Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. J Cereb Blood Flow Metab 15, 960\u2013968, https:\/\/doi.org\/10.1038\/jcbfm.1995.122 (1995).","journal-title":"J Cereb Blood Flow Metab"},{"key":"25902_CR22","doi-asserted-by":"publisher","first-page":"e0132919","DOI":"10.1371\/journal.pone.0132919","volume":"10","author":"SY Ahn","year":"2015","unstructured":"Ahn, S. Y. et al. Optimal Route for Mesenchymal Stem Cells Transplantation after Severe Intraventricular Hemorrhage in Newborn Rats. PloS one 10, e0132919, https:\/\/doi.org\/10.1371\/journal.pone.0132919 (2015).","journal-title":"PloS one"},{"key":"25902_CR23","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.mvr.2009.02.001","volume":"77","author":"D Furlani","year":"2009","unstructured":"Furlani, D. et al. Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy. Microvascular research 77, 370\u2013376, https:\/\/doi.org\/10.1016\/j.mvr.2009.02.001 (2009).","journal-title":"Microvascular research"},{"key":"25902_CR24","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.3349\/ymj.2013.54.5.1293","volume":"54","author":"JW Jung","year":"2013","unstructured":"Jung, J. W. et al. Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy. Yonsei medical journal 54, 1293\u20131296, https:\/\/doi.org\/10.3349\/ymj.2013.54.5.1293 (2013).","journal-title":"Yonsei medical journal"},{"key":"25902_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1203\/00006450-200109000-00017","volume":"50","author":"M Thoresen","year":"2001","unstructured":"Thoresen, M. et al. Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective. Pediatric research 50, 405\u2013411, https:\/\/doi.org\/10.1203\/00006450-200109000-00017 (2001).","journal-title":"Pediatric research"},{"key":"25902_CR26","first-page":"133","volume":"4","author":"L Cornette","year":"2012","unstructured":"Cornette, L. Therapeutic hypothermia in neonatal asphyxia. Facts Views Vis Obgyn 4, 133\u2013139 (2012).","journal-title":"Facts Views Vis Obgyn"},{"key":"25902_CR27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000353948","volume":"104","author":"M Thoresen","year":"2013","unstructured":"Thoresen, M. et al. Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns. Neonatology 104, 228\u2013233, https:\/\/doi.org\/10.1159\/000353948 (2013).","journal-title":"Neonatology"},{"key":"25902_CR28","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1159\/000355460","volume":"35","author":"CM Traudt","year":"2013","unstructured":"Traudt, C. M. et al. Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia. Developmental neuroscience 35, 491\u2013503, https:\/\/doi.org\/10.1159\/000355460 (2013).","journal-title":"Developmental neuroscience"},{"key":"25902_CR29","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3346\/jkms.2006.21.2.337","volume":"21","author":"WS Park","year":"2006","unstructured":"Park, W. S. et al. Neuroprotective effect of cycloheximide on hypoxic-ischemic brain injury in neonatal rats. J Korean Med Sci 21, 337\u2013341, https:\/\/doi.org\/10.3346\/jkms.2006.21.2.337 (2006).","journal-title":"J Korean Med Sci"},{"key":"25902_CR30","doi-asserted-by":"publisher","first-page":"H17","DOI":"10.1152\/ajpheart.01112.2002","volume":"285","author":"M Sakoh","year":"2003","unstructured":"Sakoh, M. & Gjedde, A. Neuroprotection in hypothermia linked to redistribution of oxygen in brain. Am J Physiol Heart Circ Physiol 285, H17\u201325, https:\/\/doi.org\/10.1152\/ajpheart.01112.2002 (2003).","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"25902_CR31","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1111\/j.1471-4159.1993.tb13639.x","volume":"61","author":"GD Zeevalk","year":"1993","unstructured":"Zeevalk, G. D. & Nicklas, W. J. Hypothermia, metabolic stress, and NMDA-mediated excitotoxicity. J Neurochem 61, 1445\u20131453 (1993).","journal-title":"J Neurochem"},{"key":"25902_CR32","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/00004647-199601000-00012","volume":"16","author":"HY Kil","year":"1996","unstructured":"Kil, H. Y., Zhang, J. & Piantadosi, C. A. Brain temperature alters hydroxyl radical production during cerebral ischemia\/reperfusion in rats. J Cereb Blood Flow Metab 16, 100\u2013106, https:\/\/doi.org\/10.1097\/00004647-199601000-00012 (1996).","journal-title":"J Cereb Blood Flow Metab"},{"key":"25902_CR33","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1097\/00001756-199710200-00033","volume":"8","author":"M Thoresen","year":"1997","unstructured":"Thoresen, M. et al. Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins. Neuroreport 8, 3359\u20133362 (1997).","journal-title":"Neuroreport"},{"key":"25902_CR34","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.brainres.2007.03.083","volume":"1154","author":"O Iwata","year":"2007","unstructured":"Iwata, O. et al. \u201cTherapeutic time window\u201d duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 1154, 173\u2013180, https:\/\/doi.org\/10.1016\/j.brainres.2007.03.083 (2007).","journal-title":"Brain Res"},{"key":"25902_CR35","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","volume":"37","author":"M Thoresen","year":"1995","unstructured":"Thoresen, M. et al. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatric research 37, 667\u2013670, https:\/\/doi.org\/10.1203\/00006450-199505000-00019 (1995).","journal-title":"Pediatric research"},{"key":"25902_CR36","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1006\/bbrc.1995.2895","volume":"217","author":"AD Edwards","year":"1995","unstructured":"Edwards, A. D. et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 217, 1193\u20131199 (1995).","journal-title":"Biochem Biophys Res Commun"},{"issue":"251","key":"25902_CR37","doi-asserted-by":"publisher","first-page":"e251","DOI":"10.1016\/j.ajog.2011.06.025","volume":"205","author":"CS Ennen","year":"2011","unstructured":"Ennen, C. S. et al. Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gynecol 205(251), e251\u2013257, https:\/\/doi.org\/10.1016\/j.ajog.2011.06.025 (2011).","journal-title":"Am J Obstet Gynecol"},{"key":"25902_CR38","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.braindev.2005.06.006","volume":"28","author":"H Aly","year":"2006","unstructured":"Aly, H., Khashaba, M. T., El-Ayouty, M., El-Sayed, O. & Hasanein, B. M. IL-1beta, IL-6 and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy. Brain & development 28, 178\u2013182, https:\/\/doi.org\/10.1016\/j.braindev.2005.06.006 (2006).","journal-title":"Brain & development"},{"key":"25902_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/pr.2011.64","volume":"71","author":"CT van Velthoven","year":"2012","unstructured":"van Velthoven, C. T., Kavelaars, A. & Heijnen, C. J. Mesenchymal stem cells as a treatment for neonatal ischemic brain damage. Pediatric research 71, 474\u2013481, https:\/\/doi.org\/10.1038\/pr.2011.64 (2012).","journal-title":"Pediatric research"},{"key":"25902_CR40","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.neuroimage.2014.12.003","volume":"107","author":"J Scholz","year":"2015","unstructured":"Scholz, J., Niibori, Y., Frankland, P. W. & Lerch, J. P. Rotarod training in mice is associated with changes in brain structure observable with multimodal MRI. NeuroImage 107, 182\u2013189, https:\/\/doi.org\/10.1016\/j.neuroimage.2014.12.003 (2015).","journal-title":"NeuroImage"},{"key":"25902_CR41","doi-asserted-by":"crossref","unstructured":"Spear, L. P. The adolescent brain and the college drinker: biological basis of propensity to use and misuse alcohol. J Stud Alcohol Suppl, 71\u201381 (2002).","DOI":"10.15288\/jsas.2002.s14.71"},{"key":"25902_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-33","volume":"6","author":"JT Lang","year":"2008","unstructured":"Lang, J. T. & McCullough, L. D. Pathways to ischemic neuronal cell death: are sex differences relevant? Journal of translational medicine 6, 33, https:\/\/doi.org\/10.1186\/1479-5876-6-33 (2008).","journal-title":"Journal of translational medicine"},{"key":"25902_CR43","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1203\/PDR.0b013e3181ef3007","volume":"68","author":"BS Lee","year":"2010","unstructured":"Lee, B. S., Woo, C. W., Kim, S. T. & Kim, K. S. Long-term neuroprotective effect of postischemic hypothermia in a neonatal rat model of severe hypoxic ischemic encephalopathy: a comparative study on the duration and depth of hypothermia. Pediatric research 68, 303\u2013308, https:\/\/doi.org\/10.1203\/00006450-201011001-0059210.1203\/PDR.0b013e3181ef3007 (2010).","journal-title":"Pediatric research"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-25902-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-25902-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-25902-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T05:23:53Z","timestamp":1671600233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-25902-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["25902"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-25902-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]},"assertion":[{"value":"1 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Won Soon Park, Yun Sil Chang, So Yoon Ahn, and Dong Kyung Sung declare potential conflicts of interest arising from a filed or issued patents titled \u201cComposition for treating neonatal HIE\u201d, \u201cComposition for treating intraventricular hemorrhage in preterm infants comprising mesenchymal stem cells\u201d. \u201cComposition for treating inflammatory brain disease which includes stem cell as active ingredient\u201d and \u201cMethod of treating lung diseases using cells separated or proliferated from umbilical cord blood\u201d as co-inventors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"7665"}}