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The aim is to explore the risk predictors of SH in post-PTX dialysis ESRD patients with SHPT. 129 consecutive dialysis patients with SHPT underwent PTX were retrospectively reviewed. A total of 22 clinical parameters were included in the study. SH was defined as the minimum values of serum calcium lower than 1.875\u2009mmol\/L (7.5\u2009mg\/dL) after surgery. Univariate analysis showed that pruritus, lumbar X-ray changes of renal osteodystrophy, pre- and post-operative intact parathyroid hormone (iPTH), Calcium, alkaline phosphatase, and gland mass were significantly different between SH and non-SH groups. In the multivariate logistic regression model, the pre-operative serum iPTH, calcium, and pruritus were independent risk predictors of SH. AUCs for pre-operative serum iPTH, calcium and pruritus were 0.810, 0.714 and 0.591, respectively. Patients with higher level of pre-operative serum iPTH, lower level of serum calcium and with no\/mild symptoms of pruritus are at greater risk of developing SH after PTX.<\/jats:p>","DOI":"10.1038\/s41598-018-26142-9","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T09:08:47Z","timestamp":1526029727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Risk factors for severe hypocalcemia after parathyroidectomy in dialysis patients with secondary hyperparathyroidism"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiaoliang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"26142_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12882-016-0421-5","volume":"18","author":"LY Ho","year":"2017","unstructured":"Ho, L. Y., Wong, P. N. & Sin, H. K. Risk factors and clinical course of hungry bone syndrome after total parathyroidectomy in dialysis patients with secondary hyperparathyroidism. Risk factors and clinical course of hungry bone syndrome after total parathyroidectomy in dialysis patients with secondary hyperparathyroidism. BMC Nephrol. 18, 12 (2017).","journal-title":"BMC Nephrol."},{"key":"26142_CR2","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s11255-015-1106-x","volume":"47","author":"D Moldovan","year":"2015","unstructured":"Moldovan, D., Racasan, S. & Kacso, I. M. Survival after parathyroidectomy in chronic hemodialysis patients with severe secondary hyperparathyroidism. Int Urol Nephrol. 47, 1871\u20131877 (2015).","journal-title":"Int Urol Nephrol."},{"key":"26142_CR3","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s11255-015-1016-y","volume":"47","author":"WC Tsa","year":"2015","unstructured":"Tsa, W. C., Peng, Y. S. & Chiu, Y. L. 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