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This study investigated the influences of IL-10 polymorphisms on the susceptibility to chronic periodontitis (CP) and aggressive periodontitis (AP), and their possible role in the quantity of subgingival bacteria<jats:italic>Aggregatibacter Actinomycetemcomitans<\/jats:italic>and<jats:italic>Porphyromonas gingivalis<\/jats:italic>. 92 CP patients, 83 AP patients and 91 periodontal healthy controls were recruited. Serum IL-10 concentration was analyzed by enzyme-linked immunosorbent assay (ELISA). Gene polymorphisms were determined by multiplex SNaPshot technique. Bacteria were quantified by real-time polymerase chain reaction with TaqMan MGB probes. Taking into account age, gender and periodontal status, IL-10-592 AA, -819 TT and ATA\/ATA genotype occurred more frequently in patients with CP than in healthy controls. In CP cases, higher quantity of subgingival<jats:italic>A<\/jats:italic>.<jats:italic>actinomycetemcomitans<\/jats:italic>and lower serum IL-10 levels could be detected in homozygous ATA\/ATA carriers. These findings indicate that variants in IL-10 promoter gene were not only associated with predisposition to chronic periodontitis but also affected the subgingival number of<jats:italic>A. Actinomycetemcomitans<\/jats:italic>in a Chinese Han population.<\/jats:p>","DOI":"10.1038\/s41598-018-26236-4","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T11:19:45Z","timestamp":1528370385000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interleukin-10 polymorphisms affect the key periodontal pathogens in Chinese periodontitis patients"],"prefix":"10.1038","volume":"8","author":[{"given":"Ying","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanzhen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mifang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"26236_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage, G. 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