{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:35:17Z","timestamp":1779183317818,"version":"3.51.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence from human and animal studies suggests that chronic behavioral stress and resulting activation of the sympathetic nervous system may influence initiation and progression of tumors. However, the underlying mechanisms for these observations are poorly understood. The purpose of this study is to explore the effects of adrenergic signaling on cell line models derived from normal cells presumed to originate epithelial ovarian cancers. Here we explored the effects of the stress-related hormone, norepinephrine, on the transcriptional program of normal immortalized ovarian (iOSE) and fallopian tube (iFTSEC) surface epithelial cells. Analysis of RNA-Seq data of treated and untreated cells revealed a significant overlap between the responses in iOSE and iFTSEC cells. Most genes modulated by norepinephrine in ovarian and fallopian tube epithelial cells are already expressed in normal ovarian and fallopian tissue and cells. For several genes, expression changes were reflected at the protein level. Genes in immune-related and developmental pathways were enriched in the set of genes modulated by norepinephrine. We identified HOXA5, SPIB, REL, SRF, SP1, NFKB1, MEF2A, E2F1, and EGR1 transcription factor binding sites to be highly enriched in our dataset. These data represent the early transcriptional response to norepinephrine in cells postulated to originate epithelial ovarian cancer.<\/jats:p>","DOI":"10.1038\/s41598-018-26670-4","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T11:04:55Z","timestamp":1527073495000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine"],"prefix":"10.1038","volume":"8","author":[{"given":"Anxhela","family":"Gjyshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Dash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Cen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Ho","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaomei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean J.","family":"Yoder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie K.","family":"Teer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo N.","family":"Armaiz-Pena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-4801","authenticated-orcid":false,"given":"Alvaro N. A.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"26670_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S1470-2045(04)01597-9","volume":"5","author":"EM Reiche","year":"2004","unstructured":"Reiche, E. M., Nunes, S. O. & Morimoto, H. K. Stress, depression, the immune system, and cancer. The Lancet. Oncology 5, 617\u2013625, https:\/\/doi.org\/10.1016\/S1470-2045(04)01597-9 (2004).","journal-title":"The Lancet. Oncology"},{"key":"26670_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/aje\/kwg002","volume":"157","author":"K Lillberg","year":"2003","unstructured":"Lillberg, K. et al. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. 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Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging. J Gerontol A Biol Sci Med Sci 56, M477\u2013482 (2001).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"26670_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF01612908","volume":"116","author":"B Vandewalle","year":"1990","unstructured":"Vandewalle, B., Revillion, F. & Lefebvre, J. Functional beta-adrenergic receptors in breast cancer cells. J Cancer Res Clin Oncol 116, 303\u2013306 (1990).","journal-title":"J Cancer Res Clin Oncol"},{"key":"26670_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0960-0760(91)90102-B","volume":"38","author":"B Marchetti","year":"1991","unstructured":"Marchetti, B., Spinola, P. G., Pelletier, G. & Labrie, F. A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth. 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