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In order to validate a bio-based control alternative for this disease, whey, lime sulfur, biofertilizer, Bordeaux mixture or raw milk were applied to kale (<jats:italic>Brassica oleracea<\/jats:italic> var. <jats:italic>acephala<\/jats:italic>) plants. The disease control was achieved by most of the tested products. Milk-based products (raw milk and whey) and biofertilizer reduced the severity by 44 and 56% in the field. Antioxidants, crude fibber, crude protein and lipid contents and kale yield were verified in the five treatments on the leaves with and without <jats:italic>X. campestris<\/jats:italic> pv. <jats:italic>campestris<\/jats:italic> inoculation. In the absence of the pathogen (non-inoculated), lime sulfur and Bordeaux mixture improved plant nutritional\u00a0value compared to organic treatments, nevertheless milk-based products and biofertilizer\u00a0improved the evaluated variables more than the control. However, on leaves inoculated with <jats:italic>X. campestris<\/jats:italic> pv. <jats:italic>campestris<\/jats:italic> raw milk increased antioxidant activity, crude protein and fiber contents, whereas biofertilizer increased kale yield, lipid and antioxidant contents. Milk-based products and biofertilizer were further evaluated in greenhouse trials to determinate the\u00a0activity of defense-related enzymes and lignin content. Biofertilizer treatment resulted in increased phenylalanine ammonia lyase, catalase, peroxidase activities and lignin content. Hence, the application of milk-based products and biofertilizer are promising to\u00a0control black rot of crucifers and also\u00a0improves food quality by boosting nutritional values and antioxidant activity.<\/jats:p>","DOI":"10.1038\/s41598-018-28086-6","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T11:45:31Z","timestamp":1530272731000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bio-based products control black rot (Xanthomonas campestris pv. campestris) and increase the nutraceutical and antioxidant components in kale"],"prefix":"10.1038","volume":"8","author":[{"given":"Andr\u00e9s M. P.","family":"Nu\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A. 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