{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:38:00Z","timestamp":1790534280591,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-098"],"award-info":[{"award-number":["2017-098"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017-528"],"award-info":[{"award-number":["2017-528"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study assessed the functional role of WNT genes and the association between WNT signalling cascades and fibrosis in interstitial cystitis\/bladder pain syndrome (IC\/BPS) patients. Twenty-five patients (3 males, 22 females; mean age 59.7\u2009\u00b1\u200910.9 years), included 7 non-Hunner-type IC (NHIC), 18 Hunner-type IC (HIC), and 5 non-IC (control) groups. The expression of sonic hedgehog, WNT gene family, and genes previously reported as biomarkers for IC\/BPS were examined using RT-PCR in biopsy specimens from the mucosa and submucosa layer of the bladder.\n                    <jats:italic>WNT2B, WNT5A<\/jats:italic>\n                    ,\n                    <jats:italic>WNT10A<\/jats:italic>\n                    , and\n                    <jats:italic>WNT11<\/jats:italic>\n                    functions in the urothelium were evaluated by silencing in an HBlEpC cell line. Pelvic Pain and Urgency\/Frequency Patient Symptom Scale scores, O\u2019Leary-Sant Symptom and Problem Index scores, and Visual Analogue Scores did not differ between the NHIC and HIC groups. However, HIC patients had significantly shorter symptom duration (30.9 vs 70.8 months, p\u2009=\u20090.046), higher daily urinary frequency (16.1 versus 8.5 times, p\u2009=\u20090.006), and smaller bladder capacity (208.6 versus 361.4\u2009ml, p\u2009=\u20090.006) than NHIC patients. Overall WNT gene expression was lower in NHIC than HIC patients. Bladder epithelial tissues from HIC patients were characterised by the downregulation of\n                    <jats:italic>WNT11<\/jats:italic>\n                    . Silencing of\n                    <jats:italic>WNT11<\/jats:italic>\n                    ,\n                    <jats:italic>WNT2B<\/jats:italic>\n                    ,\n                    <jats:italic>WNT5A<\/jats:italic>\n                    , and\n                    <jats:italic>WNT10A<\/jats:italic>\n                    in HBlEpCs resulted in fibrotic changes, indicated by fibrotic morphology, increased fibrosis-related gene expression, and nuclear localisation of phosphorylated SMAD2, and increased vimentin and fibronectin levels. Downregulation of\n                    <jats:italic>WNT11<\/jats:italic>\n                    results in fibrotic changes of bladder epithelial cells and is associated with the pathogenesis and differential diagnosis of NHIC. Decreased expression of\n                    <jats:italic>WNT11<\/jats:italic>\n                    is a potential biomarker for predicting NHIC.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-28093-7","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T05:05:33Z","timestamp":1529643933000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis\/bladder pain syndrome without Hunner lesion"],"prefix":"10.1038","volume":"8","author":[{"given":"Daeheon","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hyun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae-Min","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Yeul","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-5750","authenticated-orcid":false,"given":"Dong-Myung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Soo","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"28093_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-015-0563-1","volume":"17","author":"A Kim","year":"2016","unstructured":"Kim, A., Shin, D. M. & Choo, M. S. Stem Cell Therapy for Interstitial Cystitis\/Bladder Pain Syndrome. Curr Urol Rep 17, 1 (2016).","journal-title":"Curr Urol Rep"},{"key":"28093_CR2","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/S0022-5347(17)38437-9","volume":"145","author":"CL Parsons","year":"1991","unstructured":"Parsons, C. L., Lilly, J. D. & Stein, P. Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis). J Urol 145, 732\u2013735 (1991).","journal-title":"J Urol"},{"key":"28093_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/01.ju.0000161599.69942.2e","volume":"174","author":"VB Lokeshwar","year":"2005","unstructured":"Lokeshwar, V. B. et al. Urinary uronate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity. J Urol 174, 344\u2013349 (2005).","journal-title":"J Urol"},{"key":"28093_CR4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0094-0143(21)00590-5","volume":"21","author":"GR Sant","year":"1994","unstructured":"Sant, G. R. & Theoharides, T. C. The role of the mast cell in interstitial cystitis. The Urologic clinics of North America 21, 41\u201353 (1994).","journal-title":"The Urologic clinics of North America"},{"key":"28093_CR5","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.juro.2008.06.032","volume":"180","author":"JQ Clemens","year":"2008","unstructured":"Clemens, J. Q., Brown, S. O. & Calhoun, E. A. Mental health diagnoses in patients with interstitial cystitis\/painful bladder syndrome and chronic prostatitis\/chronic pelvic pain syndrome: a case\/control study. J Urol 180, 1378\u20131382 (2008).","journal-title":"J Urol"},{"key":"28093_CR6","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/ncpuro0874","volume":"4","author":"JP van de Merwe","year":"2007","unstructured":"van de Merwe, J. P. Interstitial cystitis and systemic autoimmune diseases. Nature clinical practice. Urology 4, 484\u2013491 (2007).","journal-title":"Nature clinical practice. Urology"},{"key":"28093_CR7","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/S0022-5347(17)42051-9","volume":"140","author":"JE Fowler Jr.","year":"1988","unstructured":"Fowler, J. E. Jr. et al. Interstitial cystitis is associated with intraurothelial Tamm-Horsfall protein. J Urol 140, 1385\u20131389 (1988).","journal-title":"J Urol"},{"key":"28093_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jama.1918.02600040001001","volume":"70","author":"GL Hunner","year":"1918","unstructured":"Hunner, G. L. A rare type of bladder ulcer: Further notes, with a report of eighteen cases. Journal of the American Medical Association 70, 203\u2013212 (1918).","journal-title":"Journal of the American Medical Association"},{"key":"28093_CR9","doi-asserted-by":"publisher","first-page":"767","DOI":"10.4111\/kju.2013.54.11.767","volume":"54","author":"J Ryu","year":"2013","unstructured":"Ryu, J. et al. Elimination of Hunner\u2019s Ulcers by Fulguration in Patients With Interstitial Cystitis: Is It Effective and Long Lasting? Korean journal of urology 54, 767\u2013771 (2013).","journal-title":"Korean journal of urology"},{"key":"28093_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/0090-4295(78)90286-8","volume":"12","author":"EM Messing","year":"1978","unstructured":"Messing, E. M. & Stamey, T. A. Interstitial cystitis: early diagnosis, pathology, and treatment. Urology 12, 381\u2013392 (1978).","journal-title":"Urology"},{"key":"28093_CR11","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/his.13235","volume":"71","author":"A Kim","year":"2017","unstructured":"Kim, A. et al. Histopathological characteristics of interstitial cystitis\/bladder pain syndrome without Hunner lesion. Histopathology 71, 415\u2013424 (2017).","journal-title":"Histopathology"},{"key":"28093_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09330-x","volume":"7","author":"A Kim","year":"2017","unstructured":"Kim, A. et al. Improved efficacy and in vivo cellular properties of human embryonic stem cell derivative in a preclinical model of bladder pain syndrome. Scientific Reports 7, 8872 (2017).","journal-title":"Scientific Reports"},{"key":"28093_CR13","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1089\/scd.2014.0459","volume":"24","author":"M Song","year":"2015","unstructured":"Song, M. et al. Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway. Stem Cells and Development 24, 1648\u20131657 (2015).","journal-title":"Stem Cells and Development"},{"key":"28093_CR14","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1096\/fj.201600502R","volume":"30","author":"D Bastakoty","year":"2016","unstructured":"Bastakoty, D. & Young, P. P. Wnt\/\u03b2-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. The FASEB Journal 30, 3271\u20133284 (2016).","journal-title":"The FASEB Journal"},{"key":"28093_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrneph.2016.54","volume":"12","author":"M Edeling","year":"2016","unstructured":"Edeling, M. et al. Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog. Nat Rev Nephrol 12, 426\u2013439 (2016).","journal-title":"Nat Rev Nephrol"},{"key":"28093_CR16","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0002-9440(10)64271-X","volume":"162","author":"EE Morrisey","year":"2003","unstructured":"Morrisey, E. E. Wnt signaling and pulmonary fibrosis. The American journal of pathology 162, 1393\u20131397 (2003).","journal-title":"The American journal of pathology"},{"key":"28093_CR17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.metabol.2015.10.013","volume":"65","author":"H Tao","year":"2016","unstructured":"Tao, H., Yang, J. J., Shi, K. H. & Li, J. Wnt signaling pathway in cardiac fibrosis: New insights and directions. Metabolism: clinical and experimental 65, 30\u201340 (2016).","journal-title":"Metabolism: clinical and experimental"},{"key":"28093_CR18","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","volume":"95","author":"CG Miao","year":"2013","unstructured":"Miao, C. G. et al. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie 95, 2326\u20132335 (2013).","journal-title":"Biochimie"},{"key":"28093_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1535370215597194","volume":"241","author":"M Li","year":"2016","unstructured":"Li, M. et al. Epithelial-mesenchymal transition: An emerging target in tissue fibrosis. Exp Biol Med (Maywood) 241, 1\u201313 (2016).","journal-title":"Exp Biol Med (Maywood)"},{"key":"28093_CR20","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"R Nusse","year":"2017","unstructured":"Nusse, R. & Clevers, H. Wnt\/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169, 985\u2013999 (2017).","journal-title":"Cell"},{"key":"28093_CR21","doi-asserted-by":"publisher","first-page":"e12299","DOI":"10.1111\/cpr.12299","volume":"50","author":"L Farahmand","year":"2017","unstructured":"Farahmand, L., Darvishi, B., Majidzadeh-A, K. & Madjid Ansari, A. Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT\/\u03b2-catenin signalling pathways. Cell Proliferation 50, e12299\u2013n\/a (2017).","journal-title":"Cell Proliferation"},{"key":"28093_CR22","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/S0022-5347(05)67638-0","volume":"163","author":"TC Chai","year":"2000","unstructured":"Chai, T. C. et al. Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis. J Urol 163, 1440\u20131444 (2000).","journal-title":"J Urol"},{"key":"28093_CR23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5213\/inj.1632522.261","volume":"20","author":"HJ Kim","year":"2016","unstructured":"Kim, H. J. Update on the Pathology and Diagnosis of Interstitial Cystitis\/Bladder Pain Syndrome: A Review. Int Neurourol J 20, 13\u201317 (2016).","journal-title":"Int Neurourol J"},{"issue":"Suppl 1","key":"28093_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/iju.12311","volume":"21","author":"HC Kuo","year":"2014","unstructured":"Kuo, H. C. Potential urine and serum biomarkers for patients with bladder pain syndrome\/interstitial cystitis. Int J Urol 21(Suppl 1), 34\u201341 (2014).","journal-title":"Int J Urol"},{"key":"28093_CR25","doi-asserted-by":"crossref","unstructured":"Niimi, A. et al. Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn (2017).","DOI":"10.1002\/nau.23431"},{"key":"28093_CR26","doi-asserted-by":"crossref","unstructured":"Chancellor, M. B., Bartolone, S. N., Veerecke, A. & Lamb, L. E. Crowdsourcing Disease Biomarker Discovery Research; The IP4IC Study. J Urol (2017).","DOI":"10.1016\/j.juro.2017.09.167"},{"key":"28093_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/MEG.0b013e32834f3123","volume":"24","author":"M Galicia-Moreno","year":"2012","unstructured":"Galicia-Moreno, M., Favari, L. & Muriel, P. Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model. European journal of gastroenterology & hepatology 24, 179\u2013185 (2012).","journal-title":"European journal of gastroenterology & hepatology"},{"key":"28093_CR28","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/j.celrep.2017.01.074","volume":"18","author":"J Heo","year":"2017","unstructured":"Heo, J. et al. Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l. Cell reports 18, 1930\u20131945 (2017).","journal-title":"Cell reports"},{"key":"28093_CR29","doi-asserted-by":"crossref","unstructured":"Jeong, E. M. et al. Real-Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function. Stem Cell Reports (2018).","DOI":"10.1016\/j.stemcr.2017.12.007"},{"key":"28093_CR30","doi-asserted-by":"crossref","unstructured":"Kim, Y. et al. Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease. Leukemia (2018).","DOI":"10.1038\/s41375-018-0151-8"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28093-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28093-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28093-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:56:26Z","timestamp":1671587786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28093-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["28093"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-28093-7","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733527022.793552388","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"27 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9782"}}