{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:35:29Z","timestamp":1790674529761,"version":"4.1.0"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/01147"],"award-info":[{"award-number":["PI15\/01147"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP15\/00180"],"award-info":[{"award-number":["CP15\/00180"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00722"],"award-info":[{"award-number":["PI16\/00722"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom&amp;#x00ED;a y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-56197-R"],"award-info":[{"award-number":["SAF2014-56197-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom&amp;#x00ED;a y Competitividad","doi-asserted-by":"publisher","award":["PCIN-2015-192-C02-01"],"award-info":[{"award-number":["PCIN-2015-192-C02-01"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom&amp;#x00ED;a y Competitividad","doi-asserted-by":"publisher","award":["SEV-2013-0317"],"award-info":[{"award-number":["SEV-2013-0317"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom&amp;#x00ED;a y Competitividad","doi-asserted-by":"publisher","award":["SAF2011-22506"],"award-info":[{"award-number":["SAF2011-22506"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom&amp;#x00ED;a y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-56197-R"],"award-info":[{"award-number":["SAF2014-56197-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcriptional dysregulation in Huntington\u2019s disease (HD) affects the expression of genes involved in survival and neuronal functions throughout the progression of the pathology. In recent years, extensive research has focused on epigenetic and chromatin-modifying factors as a causative explanation for such dysregulation, offering attractive targets for pharmacological therapies. In this work, we extensively examined the gene expression profiles in the cortex, striatum, hippocampus and cerebellum of juvenile R6\/1 and N171-82Q mice, models of rapidly progressive HD, to retrieve the early transcriptional signatures associated with this pathology. These profiles were largely consistent across HD datasets, contained tissular and neuronal-specific genes and showed significant correspondence with the transcriptional changes in mouse strains deficient for epigenetic regulatory genes. The most prominent cases were the conditional knockout of the lysine acetyltransferase CBP in post-mitotic forebrain neurons, the double knockout of the histone methyltransferases Ezh1 and Ezh2, components of the polycomb repressor complex 2 (PRC2), and the conditional mutants of the histone methyltransferases G9a (Ehmt2) and GLP (Ehmt1). Based on these observations, we propose that the neuronal epigenetic status is compromised in the prodromal stages of HD, leading to an altered transcriptional programme that is prominently involved in neuronal identity.<\/jats:p>","DOI":"10.1038\/s41598-018-28185-4","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T10:44:43Z","timestamp":1530009883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Early alteration of epigenetic-related transcription in Huntington\u2019s disease mouse models"],"prefix":"10.1038","volume":"8","author":[{"given":"Irati","family":"Herv\u00e1s-Corpi\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deisy","family":"Guiretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Alcaraz-Iborra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e1n","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Campos-Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Barco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-0565","authenticated-orcid":false,"given":"Luis M.","family":"Valor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"28185_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1152\/physrev.00041.2009","volume":"90","author":"C Zuccato","year":"2010","unstructured":"Zuccato, C., Valenza, M. & Cattaneo, E. Molecular mechanisms and potential therapeutical targets in Huntington\u2019s disease. Physiological reviews 90, 905\u2013981, https:\/\/doi.org\/10.1152\/physrev.00041.2009 (2010).","journal-title":"Physiological reviews"},{"key":"28185_CR2","doi-asserted-by":"publisher","first-page":"e4f8606b8742ef8","DOI":"10.1371\/4f8606b742ef3","volume":"4","author":"O Quarrell","year":"2012","unstructured":"Quarrell, O., O\u2019Donovan, K. L., Bandmann, O. & Strong, M. The Prevalence of Juvenile Huntington\u2019s Disease: A Review of the Literature and Meta-Analysis. PLoS currents 4, e4f8606b8742ef8603, https:\/\/doi.org\/10.1371\/4f8606b742ef3 (2012).","journal-title":"PLoS currents"},{"key":"28185_CR3","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1093\/cercor\/bhr360","volume":"22","author":"M Di Paola","year":"2012","unstructured":"Di Paola, M. et al. Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington\u2019s disease. Cerebral cortex 22, 2858\u20132866, https:\/\/doi.org\/10.1093\/cercor\/bhr360 (2012).","journal-title":"Cerebral cortex"},{"key":"28185_CR4","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1002\/mds.23762","volume":"26","author":"HD Rosas","year":"2011","unstructured":"Rosas, H. D. et al. A tale of two factors: what determines the rate of progression in Huntington\u2019s disease? A longitudinal MRI study. Movement disorders: official journal of the Movement Disorder Society 26, 1691\u20131697, https:\/\/doi.org\/10.1002\/mds.23762 (2011).","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"key":"28185_CR5","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.nicl.2016.10.009","volume":"12","author":"EM Coppen","year":"2016","unstructured":"Coppen, E. M., van der Grond, J., Hafkemeijer, A., Rombouts, S. A. & Roos, R. A. Early grey matter changes in structural covariance networks in Huntington\u2019s disease. NeuroImage. Clinical 12, 806\u2013814, https:\/\/doi.org\/10.1016\/j.nicl.2016.10.009 (2016).","journal-title":"NeuroImage. Clinical"},{"key":"28185_CR6","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1136\/jnnp-2015-312413","volume":"87","author":"F Begeti","year":"2016","unstructured":"Begeti, F., Schwab, L. C., Mason, S. L. & Barker, R. A. Hippocampal dysfunction defines disease onset in Huntington\u2019s disease. Journal of neurology, neurosurgery, and psychiatry 87, 975\u2013981, https:\/\/doi.org\/10.1136\/jnnp-2015-312413 (2016).","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"key":"28185_CR7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/ajmg.a.33911","volume":"155A","author":"G Nicolas","year":"2011","unstructured":"Nicolas, G. et al. Juvenile Huntington disease in an 18-month-old boy revealed by global developmental delay and reduced cerebellar volume. American journal of medical genetics. Part A 155A, 815\u2013818, https:\/\/doi.org\/10.1002\/ajmg.a.33911 (2011).","journal-title":"American journal of medical genetics. Part A"},{"key":"28185_CR8","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00431-004-1537-3","volume":"163","author":"S Seneca","year":"2004","unstructured":"Seneca, S. et al. Early onset Huntington disease: a neuronal degeneration syndrome. European journal of pediatrics 163, 717\u2013721, https:\/\/doi.org\/10.1007\/s00431-004-1537-3 (2004).","journal-title":"European journal of pediatrics"},{"key":"28185_CR9","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","volume":"9","author":"R Luthi-Carter","year":"2000","unstructured":"Luthi-Carter, R. et al. Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease. Human molecular genetics 9, 1259\u20131271 (2000).","journal-title":"Human molecular genetics"},{"key":"28185_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.nbd.2011.07.001","volume":"45","author":"T Seredenina","year":"2012","unstructured":"Seredenina, T. & Luthi-Carter, R. What have we learned from gene expression profiles in Huntington\u2019s disease? Neurobiology of disease 45, 83\u201398, https:\/\/doi.org\/10.1016\/j.nbd.2011.07.001 (2012).","journal-title":"Neurobiology of disease"},{"key":"28185_CR11","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s12035-014-8715-8","volume":"51","author":"LM Valor","year":"2015","unstructured":"Valor, L. M. Transcription, epigenetics and ameliorative strategies in Huntington\u2019s Disease: a genome-wide perspective. Molecular neurobiology 51, 406\u2013423, https:\/\/doi.org\/10.1007\/s12035-014-8715-8 (2015).","journal-title":"Molecular neurobiology"},{"key":"28185_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nn.4256","volume":"19","author":"P Langfelder","year":"2016","unstructured":"Langfelder, P. et al. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature neuroscience 19, 623\u2013633, https:\/\/doi.org\/10.1038\/nn.4256 (2016).","journal-title":"Nature neuroscience"},{"key":"28185_CR13","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1093\/hmg\/ddx006","volume":"26","author":"SA Ament","year":"2017","unstructured":"Ament, S. A. et al. High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington\u2019s disease CAG knock-in mice across multiple genetic backgrounds. Human molecular genetics 26, 913\u2013922, https:\/\/doi.org\/10.1093\/hmg\/ddx006 (2017).","journal-title":"Human molecular genetics"},{"key":"28185_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/srep42875","volume":"7","author":"S Le Gras","year":"2017","unstructured":"Le Gras, S. et al. Altered enhancer transcription underlies Huntington\u2019s disease striatal transcriptional signature. Scientific reports 7, 42875, https:\/\/doi.org\/10.1038\/srep42875 (2017).","journal-title":"Scientific reports"},{"key":"28185_CR15","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1093\/hmg\/ddw262","volume":"25","author":"JR Miller","year":"2016","unstructured":"Miller, J. R. et al. RNA-Seq of Huntington\u2019s disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation. Human molecular genetics 25, 2893\u20132904, https:\/\/doi.org\/10.1093\/hmg\/ddw142 (2016).","journal-title":"Human molecular genetics"},{"key":"28185_CR16","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1093\/hmg\/ddw187","volume":"25","author":"L Lin","year":"2016","unstructured":"Lin, L. et al. Transcriptome sequencing reveals aberrant alternative splicing in Huntington\u2019s disease. Human molecular genetics 25, 3454\u20133466, https:\/\/doi.org\/10.1093\/hmg\/ddw187 (2016).","journal-title":"Human molecular genetics"},{"key":"28185_CR17","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/s00702-014-1293-0","volume":"122","author":"PF Durrenberger","year":"2015","unstructured":"Durrenberger, P. F. et al. Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. Journal of neural transmission 122, 1055\u20131068, https:\/\/doi.org\/10.1007\/s00702-014-1293-0 (2015).","journal-title":"Journal of neural transmission"},{"key":"28185_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.biocel.2015.04.009","volume":"67","author":"LM Valor","year":"2015","unstructured":"Valor, L. M. Epigenetic-based therapies in the preclinical and clinical treatment of Huntington\u2019s disease. The international journal of biochemistry & cell biology 67, 45\u201348, https:\/\/doi.org\/10.1016\/j.biocel.2015.04.009 (2015).","journal-title":"The international journal of biochemistry & cell biology"},{"key":"28185_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuropharm.2013.10.025","volume":"80","author":"LM Valor","year":"2014","unstructured":"Valor, L. M. & Guiretti, D. What\u2019s wrong with epigenetics in Huntington\u2019s disease? Neuropharmacology 80, 103\u2013114, https:\/\/doi.org\/10.1016\/j.neuropharm.2013.10.025 (2014).","journal-title":"Neuropharmacology"},{"key":"28185_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fnhum.2017.00017","volume":"11","author":"L Francelle","year":"2017","unstructured":"Francelle, L., Lotz, C., Outeiro, T., Brouillet, E. & Merienne, K. Contribution of Neuroepigenetics to Huntington\u2019s Disease. Frontiers in human neuroscience 11, 17, https:\/\/doi.org\/10.3389\/fnhum.2017.00017 (2017).","journal-title":"Frontiers in human neuroscience"},{"key":"28185_CR21","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan, J. S. et al. The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription. Proceedings of the National Academy of Sciences of the United States of America 97, 6763\u20136768, https:\/\/doi.org\/10.1073\/pnas.100110097 (2000).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"28185_CR22","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/hmg\/8.9.1647","volume":"8","author":"JM Boutell","year":"1999","unstructured":"Boutell, J. M. et al. Aberrant interactions of transcriptional repressor proteins with the Huntington\u2019s disease gene product, huntingtin. Human molecular genetics 8, 1647\u20131655 (1999).","journal-title":"Human molecular genetics"},{"key":"28185_CR23","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1093\/hmg\/ddu561","volume":"24","author":"G Bai","year":"2015","unstructured":"Bai, G. et al. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Human molecular genetics 24, 1441\u20131456, https:\/\/doi.org\/10.1093\/hmg\/ddu561 (2015).","journal-title":"Human molecular genetics"},{"key":"28185_CR24","doi-asserted-by":"publisher","first-page":"e0144398","DOI":"10.1371\/journal.pone.0144398","volume":"10","author":"X Dong","year":"2015","unstructured":"Dong, X. et al. The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington\u2019s Disease. PloS one 10, e0144398, https:\/\/doi.org\/10.1371\/journal.pone.0144398 (2015).","journal-title":"PloS one"},{"key":"28185_CR25","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1093\/hmg\/ddw076","volume":"25","author":"RA De Souza","year":"2016","unstructured":"De Souza, R. A. et al. DNA methylation profiling in human Huntington\u2019s disease brain. Human molecular genetics 25, 2013\u20132030, https:\/\/doi.org\/10.1093\/hmg\/ddw076 (2016).","journal-title":"Human molecular genetics"},{"key":"28185_CR26","doi-asserted-by":"publisher","first-page":"10471","DOI":"10.1523\/JNEUROSCI.0670-13.2013","volume":"33","author":"LM Valor","year":"2013","unstructured":"Valor, L. M., Guiretti, D., Lopez-Atalaya, J. P. & Barco, A. Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. The Journal of neuroscience: the official journal of the Society for Neuroscience 33, 10471\u201310482, https:\/\/doi.org\/10.1523\/JNEUROSCI.0670-13.2013 (2013).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"28185_CR27","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1093\/hmg\/ddv099","volume":"24","author":"M Achour","year":"2015","unstructured":"Achour, M. et al. Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington\u2019s disease mice. Human molecular genetics 24, 3481\u20133496, https:\/\/doi.org\/10.1093\/hmg\/ddv099 (2015).","journal-title":"Human molecular genetics"},{"key":"28185_CR28","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1093\/hmg\/ddt214","volume":"22","author":"F Wang","year":"2013","unstructured":"Wang, F. et al. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington\u2019s disease. Human molecular genetics 22, 3641\u20133653, https:\/\/doi.org\/10.1093\/hmg\/ddt214 (2013).","journal-title":"Human molecular genetics"},{"key":"28185_CR29","doi-asserted-by":"publisher","first-page":"E3027","DOI":"10.1073\/pnas.1311323110","volume":"110","author":"M Vashishtha","year":"2013","unstructured":"Vashishtha, M. et al. Targeting H3K4 trimethylation in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America 110, E3027\u20133036, https:\/\/doi.org\/10.1073\/pnas.1311323110 (2013).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"28185_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","volume":"106-107","author":"BD Semple","year":"2013","unstructured":"Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M. & Noble-Haeusslein, L. J. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Progress in neurobiology 106\u2013107, 1\u201316, https:\/\/doi.org\/10.1016\/j.pneurobio.2013.04.001 (2013).","journal-title":"Progress in neurobiology"},{"key":"28185_CR31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainresbull.2011.10.002","volume":"88","author":"SP Brooks","year":"2012","unstructured":"Brooks, S. P., Jones, L. & Dunnett, S. B. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington\u2019s disease. Brain research bulletin 88, 81\u201393, https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.002 (2012).","journal-title":"Brain research bulletin"},{"key":"28185_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/cne.10776","volume":"465","author":"LB Menalled","year":"2003","unstructured":"Menalled, L. B., Sison, J. D., Dragatsis, I., Zeitlin, S. & Chesselet, M. F. Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington\u2019s disease with 140 CAG repeats. The Journal of comparative neurology 465, 11\u201326, https:\/\/doi.org\/10.1002\/cne.10776 (2003).","journal-title":"The Journal of comparative neurology"},{"key":"28185_CR33","doi-asserted-by":"publisher","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","volume":"7","author":"LB Menalled","year":"2012","unstructured":"Menalled, L. B. et al. Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: zQ175. PloS one 7, e49838, https:\/\/doi.org\/10.1371\/journal.pone.0049838 (2012).","journal-title":"PloS one"},{"key":"28185_CR34","doi-asserted-by":"publisher","first-page":"e0143563","DOI":"10.1371\/journal.pone.0143563","volume":"10","author":"A Labadorf","year":"2015","unstructured":"Labadorf, A. et al. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PloS one 10, e0143563, https:\/\/doi.org\/10.1371\/journal.pone.0143563 (2015).","journal-title":"PloS one"},{"key":"28185_CR35","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/hmg\/ddl013","volume":"15","author":"A Hodges","year":"2006","unstructured":"Hodges, A. et al. Regional and cellular gene expression changes in human Huntington\u2019s disease brain. Human molecular genetics 15, 965\u2013977, https:\/\/doi.org\/10.1093\/hmg\/ddl013 (2006).","journal-title":"Human molecular genetics"},{"key":"28185_CR36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.nbd.2016.02.004","volume":"89","author":"D Guiretti","year":"2016","unstructured":"Guiretti, D. et al. Specific promoter deacetylation of histone H3 is conserved across mouse models of Huntington\u2019s disease in the absence of bulk changes. Neurobiology of disease 89, 190\u2013201, https:\/\/doi.org\/10.1016\/j.nbd.2016.02.004 (2016).","journal-title":"Neurobiology of disease"},{"key":"28185_CR37","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.cell.2008.10.029","volume":"135","author":"JP Doyle","year":"2008","unstructured":"Doyle, J. P. et al. Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell 135, 749\u2013762, https:\/\/doi.org\/10.1016\/j.cell.2008.10.029 (2008).","journal-title":"Cell"},{"key":"28185_CR38","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.cell.2008.10.028","volume":"135","author":"M Heiman","year":"2008","unstructured":"Heiman, M. et al. A translational profiling approach for the molecular characterization of CNS cell types. Cell 135, 738\u2013748, https:\/\/doi.org\/10.1016\/j.cell.2008.10.028 (2008).","journal-title":"Cell"},{"key":"28185_CR39","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/hmg\/8.3.397","volume":"8","author":"G Schilling","year":"1999","unstructured":"Schilling, G. et al. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Human molecular genetics 8, 397\u2013407 (1999).","journal-title":"Human molecular genetics"},{"key":"28185_CR40","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1083\/jcb.200508072","volume":"171","author":"JY Shin","year":"2005","unstructured":"Shin, J. Y. et al. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. The Journal of cell biology 171, 1001\u20131012, https:\/\/doi.org\/10.1083\/jcb.200508072 (2005).","journal-title":"The Journal of cell biology"},{"key":"28185_CR41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/glia.23050","volume":"65","author":"AH Jansen","year":"2017","unstructured":"Jansen, A. H. et al. Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific. Glia 65, 50\u201361, https:\/\/doi.org\/10.1002\/glia.23050 (2017).","journal-title":"Glia"},{"key":"28185_CR42","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.neuron.2009.11.019","volume":"64","author":"A Schaefer","year":"2009","unstructured":"Schaefer, A. et al. Control of cognition and adaptive behavior by the GLP\/G9a epigenetic suppressor complex. Neuron 64, 678\u2013691, https:\/\/doi.org\/10.1016\/j.neuron.2009.11.019 (2009).","journal-title":"Neuron"},{"key":"28185_CR43","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/nn.4360","volume":"19","author":"M von Schimmelmann","year":"2016","unstructured":"von Schimmelmann, M. et al. Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nature neuroscience 19, 1321\u20131330, https:\/\/doi.org\/10.1038\/nn.4360 (2016).","journal-title":"Nature neuroscience"},{"key":"28185_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5450","volume":"5","author":"S Ito","year":"2014","unstructured":"Ito, S. et al. Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nature communications 5, 4450, https:\/\/doi.org\/10.1038\/ncomms5450 (2014).","journal-title":"Nature communications"},{"key":"28185_CR45","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cell.2013.01.038","volume":"152","author":"SA Baker","year":"2013","unstructured":"Baker, S. A. et al. An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. Cell 152, 984\u2013996, https:\/\/doi.org\/10.1016\/j.cell.2013.01.038 (2013).","journal-title":"Cell"},{"key":"28185_CR46","doi-asserted-by":"publisher","first-page":"8072","DOI":"10.1093\/nar\/gkt590","volume":"41","author":"JP Lopez-Atalaya","year":"2013","unstructured":"Lopez-Atalaya, J. P., Ito, S., Valor, L. M., Benito, E. & Barco, A. Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. Nucleic acids research 41, 8072\u20138084, https:\/\/doi.org\/10.1093\/nar\/gkt590 (2013).","journal-title":"Nucleic acids research"},{"key":"28185_CR47","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1172\/JCI43428","volume":"121","author":"M Kraft","year":"2011","unstructured":"Kraft, M. et al. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. The Journal of clinical investigation 121, 3479\u20133491, https:\/\/doi.org\/10.1172\/JCI43428 (2011).","journal-title":"The Journal of clinical investigation"},{"key":"28185_CR48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1073\/pnas.1611431114","volume":"114","author":"JS Benjamin","year":"2017","unstructured":"Benjamin, J. S. et al. A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome. Proceedings of the National Academy of Sciences of the United States of America 114, 125\u2013130, https:\/\/doi.org\/10.1073\/pnas.1611431114 (2017).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"28185_CR49","doi-asserted-by":"publisher","first-page":"e1001717","DOI":"10.1371\/journal.pbio.1001717","volume":"11","author":"M Mielcarek","year":"2013","unstructured":"Mielcarek, M. et al. HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration. PLoS biology 11, e1001717, https:\/\/doi.org\/10.1371\/journal.pbio.1001717 (2013).","journal-title":"PLoS biology"},{"key":"28185_CR50","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1038\/emboj.2011.299","volume":"30","author":"JP Lopez-Atalaya","year":"2011","unstructured":"Lopez-Atalaya, J. P. et al. CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement. The EMBO journal 30, 4287\u20134298, https:\/\/doi.org\/10.1038\/emboj.2011.299 (2011).","journal-title":"The EMBO journal"},{"key":"28185_CR51","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/jmedgenet-2011-100354","volume":"49","author":"JP Lopez-Atalaya","year":"2012","unstructured":"Lopez-Atalaya, J. P. et al. Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. Journal of medical genetics 49, 66\u201374, https:\/\/doi.org\/10.1136\/jmedgenet-2011-100354 (2012).","journal-title":"Journal of medical genetics"},{"key":"28185_CR52","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1523\/JNEUROSCI.4737-10.2011","volume":"31","author":"LM Valor","year":"2011","unstructured":"Valor, L. M. et al. Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability. The Journal of neuroscience: the official journal of the Society for Neuroscience 31, 1652\u20131663, https:\/\/doi.org\/10.1523\/JNEUROSCI.4737-10.2011 (2011).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"28185_CR53","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nn.4194","volume":"19","author":"R Halder","year":"2016","unstructured":"Halder, R. et al. DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nature neuroscience 19, 102\u2013110, https:\/\/doi.org\/10.1038\/nn.4194 (2016).","journal-title":"Nature neuroscience"},{"key":"28185_CR54","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1093\/hmg\/ddr195","volume":"20","author":"JC Jacobsen","year":"2011","unstructured":"Jacobsen, J. C. et al. HD CAG-correlated gene expression changes support a simple dominant gain of function. Human molecular genetics 20, 2846\u20132860, https:\/\/doi.org\/10.1093\/hmg\/ddr195 (2011).","journal-title":"Human molecular genetics"},{"key":"28185_CR55","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","volume":"16","author":"A Kuhn","year":"2007","unstructured":"Kuhn, A. et al. Mutant huntingtin\u2019s effects on striatal gene expression in mice recapitulate changes observed in human Huntington\u2019s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human molecular genetics 16, 1845\u20131861, https:\/\/doi.org\/10.1093\/hmg\/ddm133 (2007).","journal-title":"Human molecular genetics"},{"key":"28185_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-014-0060-2","volume":"7","author":"A Neueder","year":"2014","unstructured":"Neueder, A. & Bates, G. P. A common gene expression signature in Huntington\u2019s disease patient brain regions. BMC medical genomics 7, 60, https:\/\/doi.org\/10.1186\/s12920-014-0060-2 (2014).","journal-title":"BMC medical genomics"},{"key":"28185_CR57","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1093\/hmg\/ddr355","volume":"20","author":"E Fossale","year":"2011","unstructured":"Fossale, E. et al. Differential effects of the Huntington\u2019s disease CAG mutation in striatum and cerebellum are quantitative not qualitative. Human molecular genetics 20, 4258\u20134267, https:\/\/doi.org\/10.1093\/hmg\/ddr355 (2011).","journal-title":"Human molecular genetics"},{"key":"28185_CR58","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nn.3670","volume":"17","author":"I Maze","year":"2014","unstructured":"Maze, I. et al. G9a influences neuronal subtype specification in striatum. Nature neuroscience 17, 533\u2013539, https:\/\/doi.org\/10.1038\/nn.3670 (2014).","journal-title":"Nature neuroscience"},{"key":"28185_CR59","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuron.2011.09.035","volume":"73","author":"SE Ross","year":"2012","unstructured":"Ross, S. E. et al. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron 73, 292\u2013303, https:\/\/doi.org\/10.1016\/j.neuron.2011.09.035 (2012).","journal-title":"Neuron"},{"key":"28185_CR60","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2708-7","author":"A Kavyanifar","year":"2017","unstructured":"Kavyanifar, A., Turan, S. & Lie, D. C. SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell and tissue research. https:\/\/doi.org\/10.1007\/s00441-017-2708-7 (2017).","journal-title":"Cell and tissue research"},{"key":"28185_CR61","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3389\/fnins.2015.00509","volume":"9","author":"E Kerschbamer","year":"2015","unstructured":"Kerschbamer, E. & Biagioli, M. Huntington\u2019s Disease as Neurodevelopmental Disorder: Altered Chromatin Regulation, Coding, and Non-Coding RNATranscription. Frontiers in neuroscience 9, 509, https:\/\/doi.org\/10.3389\/fnins.2015.00509 (2015).","journal-title":"Frontiers in neuroscience"},{"key":"28185_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02257-3","volume":"7","author":"F Cao","year":"2017","unstructured":"Cao, F. et al. Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions. Scientific reports 7, 2186, https:\/\/doi.org\/10.1038\/s41598-017-02257-3 (2017).","journal-title":"Scientific reports"},{"key":"28185_CR63","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493\u2013506 (1996).","journal-title":"Cell"},{"key":"28185_CR64","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/gene.20068","volume":"40","author":"Z Zhang","year":"2004","unstructured":"Zhang, Z., Hofmann, C., Casanova, E., Schutz, G. & Lutz, B. Generation of a conditional allele of the CBP gene in mouse. Genesis 40, 82\u201389, https:\/\/doi.org\/10.1002\/gene.20068 (2004).","journal-title":"Genesis"},{"key":"28185_CR65","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-63","volume":"8","author":"G Erdmann","year":"2007","unstructured":"Erdmann, G., Schutz, G. & Berger, S. Inducible gene inactivation in neurons of the adult mouse forebrain. BMC neuroscience 8, 63, https:\/\/doi.org\/10.1186\/1471-2202-8-63 (2007).","journal-title":"BMC neuroscience"},{"key":"28185_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome biology 5, R80, https:\/\/doi.org\/10.1186\/gb-2004-5-10-r80 (2004).","journal-title":"Genome biology"},{"key":"28185_CR67","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1093\/bioinformatics\/bti270","volume":"21","author":"GK Smyth","year":"2005","unstructured":"Smyth, G. K., Michaud, J. & Scott, H. S. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21, 2067\u20132075, https:\/\/doi.org\/10.1093\/bioinformatics\/bti270 (2005).","journal-title":"Bioinformatics"},{"key":"28185_CR68","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","volume":"20","author":"L Gautier","year":"2004","unstructured":"Gautier, L., Cope, L., Bolstad, B. M. & Irizarry, R. A. affy\u2013analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307\u2013315, https:\/\/doi.org\/10.1093\/bioinformatics\/btg405 (2004).","journal-title":"Bioinformatics"},{"key":"28185_CR69","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/hmg\/ddq018","volume":"19","author":"K Becanovic","year":"2010","unstructured":"Becanovic, K. et al. Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis. Human molecular genetics 19, 1438\u20131452, https:\/\/doi.org\/10.1093\/hmg\/ddq018 (2010).","journal-title":"Human molecular genetics"},{"key":"28185_CR70","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1172\/JCI57413","volume":"121","author":"J Labbadia","year":"2011","unstructured":"Labbadia, J. et al. Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease. The Journal of clinical investigation 121, 3306\u20133319, https:\/\/doi.org\/10.1172\/JCI57413 (2011).","journal-title":"The Journal of clinical investigation"},{"key":"28185_CR71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.brainresbull.2011.10.001","volume":"88","author":"P Giles","year":"2012","unstructured":"Giles, P. et al. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington\u2019s disease. Brain research bulletin 88, 199\u2013209, https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.001 (2012).","journal-title":"Brain research bulletin"},{"key":"28185_CR72","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1093\/hmg\/ddt598","volume":"23","author":"FM Ribeiro","year":"2014","unstructured":"Ribeiro, F. M. et al. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington\u2019s disease. Human molecular genetics 23, 2030\u20132042, https:\/\/doi.org\/10.1093\/hmg\/ddt598 (2014).","journal-title":"Human molecular genetics"},{"key":"28185_CR73","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1093\/hmg\/ddu522","volume":"24","author":"M Kurosawa","year":"2015","unstructured":"Kurosawa, M. et al. Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington\u2019s model mice. Human molecular genetics 24, 1092\u20131105, https:\/\/doi.org\/10.1093\/hmg\/ddu522 (2015).","journal-title":"Human molecular genetics"},{"key":"28185_CR74","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2251-4","volume":"16","author":"Z Bayram-Weston","year":"2015","unstructured":"Bayram-Weston, Z. et al. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington\u2019s disease are not reflected in mutant Huntingtin inclusion prevalence. BMC genomics 16, 1079, https:\/\/doi.org\/10.1186\/s12864-015-2251-4 (2015).","journal-title":"BMC genomics"},{"key":"28185_CR75","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.neuroscience.2009.12.054","volume":"166","author":"A Kurz","year":"2010","unstructured":"Kurz, A. et al. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization. Neuroscience 166, 785\u2013795, https:\/\/doi.org\/10.1016\/j.neuroscience.2009.12.054 (2010).","journal-title":"Neuroscience"},{"key":"28185_CR76","doi-asserted-by":"publisher","first-page":"e11464","DOI":"10.1371\/journal.pone.0011464","volume":"5","author":"A Kurz","year":"2010","unstructured":"Kurz, A. et al. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PloS one 5, e11464, https:\/\/doi.org\/10.1371\/journal.pone.0011464 (2010).","journal-title":"PloS one"},{"key":"28185_CR77","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10571-010-9629-2","volume":"31","author":"YG Choi","year":"2011","unstructured":"Choi, Y. G., Yeo, S., Hong, Y. M. & Lim, S. Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis. Cellular and molecular neurobiology 31, 377\u2013391, https:\/\/doi.org\/10.1007\/s10571-010-9629-2 (2011).","journal-title":"Cellular and molecular neurobiology"},{"key":"28185_CR78","doi-asserted-by":"publisher","first-page":"e85510","DOI":"10.1371\/journal.pone.0085510","volume":"9","author":"V Dorval","year":"2014","unstructured":"Dorval, V. et al. Gene and MicroRNA transcriptome analysis of Parkinson\u2019s related LRRK2 mouse models. PloS one 9, e85510, https:\/\/doi.org\/10.1371\/journal.pone.0085510 (2014).","journal-title":"PloS one"},{"key":"28185_CR79","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1093\/hmg\/ddu520","volume":"24","author":"S Gispert","year":"2015","unstructured":"Gispert, S. et al. Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Human molecular genetics 24, 1061\u20131076, https:\/\/doi.org\/10.1093\/hmg\/ddu520 (2015).","journal-title":"Human molecular genetics"},{"key":"28185_CR80","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/nn2011","volume":"10","author":"MJ Friedman","year":"2007","unstructured":"Friedman, M. J. et al. Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nature neuroscience 10, 1519\u20131528, https:\/\/doi.org\/10.1038\/nn2011 (2007).","journal-title":"Nature neuroscience"},{"key":"28185_CR81","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1073\/pnas.0711257105","volume":"105","author":"JR Gatchel","year":"2008","unstructured":"Gatchel, J. R. et al. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proceedings of the National Academy of Sciences of the United States of America 105, 1291\u20131296, https:\/\/doi.org\/10.1073\/pnas.0711257105 (2008).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"28185_CR82","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10048-015-0441-5","volume":"16","author":"M Fittschen","year":"2015","unstructured":"Fittschen, M. et al. Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate. Neurogenetics 16, 181\u2013192, https:\/\/doi.org\/10.1007\/s10048-015-0441-5 (2015).","journal-title":"Neurogenetics"},{"key":"28185_CR83","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1093\/hmg\/ddv202","volume":"24","author":"T Aikawa","year":"2015","unstructured":"Aikawa, T. et al. Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. Human molecular genetics 24, 4780\u20134791, https:\/\/doi.org\/10.1093\/hmg\/ddv202 (2015).","journal-title":"Human molecular genetics"},{"key":"28185_CR84","doi-asserted-by":"publisher","first-page":"e0183264","DOI":"10.1371\/journal.pone.0183264","volume":"12","author":"LM Valor","year":"2017","unstructured":"Valor, L. M., Rodriguez-Bayona, B., Ramos-Amaya, A. B., Brieva, J. A. & Campos-Caro, A. The transcriptional profiling of human in vivo-generated plasma cells identifies selective imbalances in monoclonal gammopathies. PloS one 12, e0183264, https:\/\/doi.org\/10.1371\/journal.pone.0183264 (2017).","journal-title":"PloS one"},{"key":"28185_CR85","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/glia.22969","volume":"64","author":"L Pardo","year":"2016","unstructured":"Pardo, L. et al. Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury. Glia 64, 853\u2013874, https:\/\/doi.org\/10.1002\/glia.22969 (2016).","journal-title":"Glia"},{"key":"28185_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06231-x","volume":"7","author":"L Pardo","year":"2017","unstructured":"Pardo, L. et al. CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons. Scientific reports 7, 6390, https:\/\/doi.org\/10.1038\/s41598-017-06231-x (2017).","journal-title":"Scientific reports"},{"key":"28185_CR87","doi-asserted-by":"publisher","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","volume":"32","author":"JL Zamanian","year":"2012","unstructured":"Zamanian, J. L. et al. Genomic analysis of reactive astrogliosis. The Journal of neuroscience: the official journal of the Society for Neuroscience 32, 6391\u20136410, https:\/\/doi.org\/10.1523\/JNEUROSCI.6221-11.2012 (2012).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"28185_CR88","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-4-5","volume":"4","author":"JE Lattin","year":"2008","unstructured":"Lattin, J. E. et al. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome research 4, 5, https:\/\/doi.org\/10.1186\/1745-7580-4-5 (2008).","journal-title":"Immunome research"},{"key":"28185_CR89","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1126\/science.1226929","volume":"338","author":"D Friedmann-Morvinski","year":"2012","unstructured":"Friedmann-Morvinski, D. et al. Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science 338, 1080\u20131084, https:\/\/doi.org\/10.1126\/science.1226929 (2012).","journal-title":"Science"},{"key":"28185_CR90","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/cdd.2010.40","volume":"17","author":"LM Valor","year":"2010","unstructured":"Valor, L. M., Jancic, D., Lujan, R. & Barco, A. Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function. Cell death and differentiation 17, 1636\u20131644, https:\/\/doi.org\/10.1038\/cdd.2010.40 (2010).","journal-title":"Cell death and differentiation"},{"key":"28185_CR91","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.aaa0355","volume":"348","author":"M Mele","year":"2015","unstructured":"Mele, M. et al. Human genomics. The human transcriptome across tissues and individuals. Science 348, 660\u2013665, https:\/\/doi.org\/10.1126\/science.aaa0355 (2015).","journal-title":"The human transcriptome across tissues and individuals. Science"},{"key":"28185_CR92","doi-asserted-by":"publisher","first-page":"W77","DOI":"10.1093\/nar\/gkt439","volume":"41","author":"J Wang","year":"2013","unstructured":"Wang, J., Duncan, D., Shi, Z. & Zhang, B. WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic acids research 41, W77\u201383, https:\/\/doi.org\/10.1093\/nar\/gkt439 (2013).","journal-title":"Nucleic acids research"},{"key":"28185_CR93","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1038\/npp.2009.125","volume":"34","author":"C Sanchis-Segura","year":"2009","unstructured":"Sanchis-Segura, C., Lopez-Atalaya, J. P. & Barco, A. Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 34, 2642\u20132654, https:\/\/doi.org\/10.1038\/npp.2009.125 (2009).","journal-title":"Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology"},{"key":"28185_CR94","doi-asserted-by":"publisher","first-page":"13909","DOI":"10.1523\/JNEUROSCI.3850-07.2007","volume":"27","author":"M Lopez de Armentia","year":"2007","unstructured":"Lopez de Armentia, M. et al. cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. The Journal of neuroscience: the official journal of the Society for Neuroscience 27, 13909\u201313918, https:\/\/doi.org\/10.1523\/JNEUROSCI.3850-07.2007 (2007).","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28185-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28185-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28185-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T06:58:38Z","timestamp":1671605918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-28185-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":94,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["28185"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-28185-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,2]]},"assertion":[{"value":"12 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9925"}}