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Fungal-based biopesticides are promising alternatives to synthetic insecticides because they are ecofriendly and are highly effective at infecting insects through contact. This study evaluated the susceptibility of the yellow fever mosquito <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> to a range of entomopathogenic fungal strains from the genus <jats:italic>Isaria<\/jats:italic>. We observed a diverse variation in the virulence of the <jats:italic>Isaria<\/jats:italic> strains tested, with two strains showing high pathogenicity towards adult mosquitoes. Mosquito susceptibility to fungal infection was further corroborated through the molecular quantification of fungal loads and the transcript evaluation of a fungal-specific pathogen recognition molecule in the mosquito body. Moreover, quantitative analysis of transcript abundance coupled with enzymatic assays revealed strain-specific subversion of the melanization cascade, an important immune response component. Our study contributes critical insights for a better understanding of fungal-mosquito interactions.<\/jats:p>","DOI":"10.1038\/s41598-018-28210-6","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T09:11:52Z","timestamp":1530004312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Strain-specific pathogenicity and subversion of phenoloxidase activity in the mosquito Aedes aegypti by members of the fungal entomopathogenic genus Isaria"],"prefix":"10.1038","volume":"8","author":[{"given":"Jos\u00e9 L.","family":"Ramirez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephantus J.","family":"Muturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dunlap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro P.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"28210_CR1","doi-asserted-by":"publisher","first-page":"910","DOI":"10.4269\/ajtmh.2008.78.910","volume":"78","author":"M Farenhorst","year":"2008","unstructured":"Farenhorst, M. et al. 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