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To assess whether \u03b2-barrel oligomers are common intermediates to amyloid peptides - a necessary step toward associating \u03b2-barrel oligomers with general amyloid cytotoxicity, we computationally studied the oligomerization and fibrillization dynamics of seven well-studied fragments of amyloidogenic proteins with different experimentally-determined aggregation morphologies and cytotoxicity. In our molecular dynamics simulations, \u03b2-barrel oligomers were only observed in five peptides self-assembling into the characteristic cross-\u03b2 aggregates, but not the other two that formed polymorphic \u03b2-rich aggregates as reported experimentally. Interestingly, the latter two peptides were previously found nontoxic. Hence, the observed correlation between \u03b2-barrel oligomers formation and cytotoxicity supports the hypothesis of \u03b2-barrel oligomers as the common toxic intermediates of amyloid aggregation.<\/jats:p>","DOI":"10.1038\/s41598-018-28649-7","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T14:13:22Z","timestamp":1530627202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["\u03b2-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-\u03b2 Aggregates"],"prefix":"10.1038","volume":"8","author":[{"given":"Yunxiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-6185","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-6336","authenticated-orcid":false,"given":"Feng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"28649_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy, J. & Selkoe, D. 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