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Paradoxically, despite a reduction in transduction currents in\n                    <jats:italic>Ano2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ORNs, their spike output for odor stimuli may be higher. We examined the role of Ano2 in ORNs in their native environment in freely breathing mice by imaging activity in ORN axons as they arrive in the olfactory bulb glomeruli. Odor-evoked responses in ORN axons of\n                    <jats:italic>Ano2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    animals were consistently larger for a variety of odorants and concentrations. In an open arena,\n                    <jats:italic>Ano2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    animals took longer to approach a localized odor source than\n                    <jats:italic>Ano2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/+<\/jats:italic>\n                    <\/jats:sup>\n                    animals, revealing clear olfactory behavioral deficits. Our studies provide the first\n                    <jats:italic>in vivo<\/jats:italic>\n                    evidence toward an alternative or additional role for Ano2 in the olfactory transduction cascade, where it may serve as a feedback mechanism to clamp ORN spike output.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-28855-3","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T05:28:11Z","timestamp":1531114091000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons"],"prefix":"10.1038","volume":"8","author":[{"given":"Joseph D.","family":"Zak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-1131","authenticated-orcid":false,"given":"Julien","family":"Grimaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-8590","authenticated-orcid":false,"given":"Chih-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-4252","authenticated-orcid":false,"given":"Venkatesh N.","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"28855_CR1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1152\/physrev.1998.78.2.429","volume":"78","author":"D Schild","year":"1998","unstructured":"Schild, D. & Restrepo, D. 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