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Recently we have reported that content of these compounds in\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>sclarea<\/jats:italic>\n                    hairy roots is strongly depending on transcriptional regulation of genes belonging to the plastidial MEP-dependent terpenoid pathway, from which they mostly derive. To boost the synthesis of this interesting class of compounds, heterologous\n                    <jats:italic>At<\/jats:italic>\n                    WRKY18,\n                    <jats:italic>At<\/jats:italic>\n                    WRKY40, and\n                    <jats:italic>At<\/jats:italic>\n                    MYC2 TFs were overexpressed in\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>sclarea<\/jats:italic>\n                    hairy roots and proved to regulate in a coordinated manner the expression of several genes encoding enzymes of the MEP-dependent pathway, especially DXS, DXR, GGPPS and CPPS. The content of total abietane diterpenes was enhanced in all overexpressing lines, although in a variable manner due to a negative pleiotropic effect on HR growth. Interestingly, in the best performing HR lines overexpressing the\n                    <jats:italic>At<\/jats:italic>\n                    WRKY40 TF induced a significant 4-fold increase in the final yield of aethiopinone, for which we have reported an interesting anti-proliferative activity against resistant melanoma cells. The present results are also informative and instrumental to enhance the synthesis of abietane diterpenes derived from the plastidial MEP-derived terpenoid pathway in other\n                    <jats:italic>Salvia<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-29389-4","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T06:44:17Z","timestamp":1531723457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Coactivation of MEP-biosynthetic genes and accumulation of abietane diterpenes in Salvia sclarea by heterologous expression of WRKY and MYC2 transcription factors"],"prefix":"10.1038","volume":"8","author":[{"given":"Mariaevelina","family":"Alfieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cappetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ambrosone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunziatina","family":"De Tommasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"29389_CR1","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1039\/C4NP00110A","volume":"32","author":"MA Gonzalez","year":"2015","unstructured":"Gonzalez, M. 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