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Some of the drawbacks of most chemotherapy are lack of target selectivity to tumor cells, and adverse drug reaction, which limit the treatment intensity and frequency. Herein, we synthesized the prodrug of triptolide (TP) coupled to vitamin E (VE) using dithiodiglycolic acid and co-dissolved with PEG2000- linoleic acid (MPEG200-LD) in ethanol. The PEGylated TP prodrug self-assembly nanoparticles (PTPPSN) were prepared via nanoprecipitation method. Besides, characterization, stability and <jats:italic>in vitro<\/jats:italic> release of the PEGylated nanometer prodrug were investigated. Furthermore, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> antitumor efficacy of PTPPSN explored showed that the cytotoxicity of triptolide was significantly reduced <jats:italic>in vitro<\/jats:italic> preparation. However, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> antitumor effect of PTPPSN was significantly improved compared to the original triptolide. In summary, the PEGylated nanoparticle successfully encapsulated triptolide yielded suitable cell microenvironment, and nanotechnology-related achievements. This study, therefore, provides a new method for antitumor research as well as an innovative technology for clinical treatment of malignant tumor.<\/jats:p>","DOI":"10.1038\/s41598-018-29692-0","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T10:37:40Z","timestamp":1534934260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Redox-responsive self-assembly PEG nanoparticle enhanced triptolide for efficient antitumor treatment"],"prefix":"10.1038","volume":"8","author":[{"given":"Yanchun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"29692_CR1","doi-asserted-by":"publisher","first-page":"11003","DOI":"10.1073\/pnas.0604507103","volume":"103","author":"W Wang","year":"2006","unstructured":"Wang, W., Kim, S. 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