{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:39:54Z","timestamp":1793947194482,"version":"4.8.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corneal neovascularization (CoNV) could be treated\u00a0by novel anti-angiogenic therapies, though\u00a0reliable and objective imaging tools to evaluate corneal vasculature and\u00a0treatment efficacy is still\u00a0lacking. Optical coherence tomography angiography (OCTA) \u2013currently designed as\u00a0a retinal vascular imaging system\u2014 has been\u00a0recently adapted for anterior-segment and showed good potential\u00a0for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological comparison. Our study evaluated the OCTA in suture-induced CoNV in a rabbit model compared to indocyanine green angiography (ICGA) and slit-lamp photography (SLP). Overall vessel density measurements from OCTA showed good correlation with ICGA (0.957) and SLP (0.992). Vessels density by OCTA was higher than ICGA and SLP (mean\u2009=\u200920.77\u2009\u00b1\u20099.8%, 15.71\u2009\u00b1\u20096.28% and 17.55\u2009\u00b1\u20098.36%, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). OCTA was able to depict CoNV similarly to SLP and ICGA, though it could better detect small vessels. Moreover, the depth and growth of vessels could be assessed using en-face and serial-scans. This study validated the OCTA in a rabbit model as a useful\u00a0imaging tool for translational studies on CoNV. This may\u00a0contribute to further\u00a0studies on OCTA for anterior-segment including serial\u00a0evaluation of emerging anti-angiogenic therapies.<\/jats:p>","DOI":"10.1038\/s41598-018-29752-5","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T10:56:55Z","timestamp":1532516215000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-4891","authenticated-orcid":false,"given":"Tisha P.","family":"Stanzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyein C.","family":"Lwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary H.","family":"Yam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodhbir S.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"29752_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/ACI.0b013e32833dfa11","volume":"10","author":"JY Niederkorn","year":"2010","unstructured":"Niederkorn, J. Y. High-risk corneal allografts and why they lose their immune privilege. Curr Opin Allergy Clin Immunol 10, 493\u2013497 (2010).","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"29752_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","volume":"22","author":"C Cursiefen","year":"2003","unstructured":"Cursiefen, C., Chen, L., Dana, M. R. & Streilein, J. W. Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology. Cornea 22, 273\u2013281 (2003).","journal-title":"Cornea"},{"key":"29752_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/00055735-200108000-00002","volume":"12","author":"JH Chang","year":"2001","unstructured":"Chang, J. H., Gabison, E. E., Kato, T. & Azar, D. T. Corneal neovascularization. Curr Opin Ophthalmol 12, 242\u2013249 (2001).","journal-title":"Curr Opin Ophthalmol"},{"key":"29752_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jtos.2012.01.005","volume":"10","author":"W Stevenson","year":"2012","unstructured":"Stevenson, W., Cheng, S. F., Dastjerdi, M. H., Ferrari, G. & Dana, R. Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin). Ocul Surf 10, 67\u201383 (2012).","journal-title":"Ocul Surf"},{"key":"29752_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.preteyeres.2013.01.001","volume":"34","author":"F Bock","year":"2013","unstructured":"Bock, F. et al. Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases. Prog Retin Eye Res 34, 89\u2013124 (2013).","journal-title":"Prog Retin Eye Res"},{"key":"29752_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.survophthal.2012.01.007","volume":"57","author":"JH Chang","year":"2012","unstructured":"Chang, J. H. et al. Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol 57, 415\u2013429 (2012).","journal-title":"Surv Ophthalmol"},{"key":"29752_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/bjo.2011.204701","volume":"96","author":"C Cursiefen","year":"2012","unstructured":"Cursiefen, C. et al. Consensus statement on indications for anti-angiogenic therapy in the management of corneal diseases associated with neovascularisation: outcome of an expert roundtable. Br J Ophthalmol 96, 3\u20139 (2012).","journal-title":"Br J Ophthalmol"},{"key":"29752_CR8","first-page":"327","volume":"51","author":"L Coman","year":"2010","unstructured":"Coman, L., Coman, O. A., Paunescu, H., Draghia, F. & Fulga, I. VEGF-induced corneal neovascularisation in a rabbit experimental model. Rom J Morphol Embryol 51, 327\u2013336 (2010).","journal-title":"Rom J Morphol Embryol"},{"key":"29752_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1136\/bjophthalmol-2012-302137","volume":"97","author":"C Petsoglou","year":"2013","unstructured":"Petsoglou, C. et al. Subconjunctival bevacizumab induces regression of corneal neovascularisation: a pilot randomised placebo-controlled double-masked trial. Br J Ophthalmol 97, 28\u201332 (2013).","journal-title":"Br J Ophthalmol"},{"key":"29752_CR10","first-page":"426","volume":"70","author":"TJ Conrad","year":"1994","unstructured":"Conrad, T. J., Chandler, D. B., Corless, J. M. & Klintworth, G. K. In vivo measurement of corneal angiogenesis with video data acquisition and computerized image analysis. Lab Invest 70, 426\u2013434 (1994).","journal-title":"Lab Invest"},{"key":"29752_CR11","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.1167\/iovs.15-17098","volume":"56","author":"A Rabiolo","year":"2015","unstructured":"Rabiolo, A., Bignami, F., Rama, P. & Ferrari, G. VesselJ: A New Tool for Semiautomatic Measurement of Corneal Neovascularization. Invest Ophthalmol Vis Sci 56, 8199\u20138206 (2015).","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"29752_CR12","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1136\/bjophthalmol-2011-300638","volume":"95","author":"A Tatham","year":"2011","unstructured":"Tatham, A., Tatham, E. & Prydal, J. Validation of a semi-automated computer-aided technique for quantifying corneal vascularisation and scarring. Br J Ophthalmol 95, 1379\u20131384 (2011).","journal-title":"Br J Ophthalmol"},{"key":"29752_CR13","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.ajo.2012.04.021","volume":"154","author":"RP Kirwan","year":"2012","unstructured":"Kirwan, R. P. et al. Quantifying changes in corneal neovascularization using fluorescein and indocyanine green angiography. Am J Ophthalmol 154, 850\u2013858 e852 (2012).","journal-title":"Am J Ophthalmol"},{"key":"29752_CR14","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s11739-013-1019-6","volume":"9","author":"SO Ha","year":"2014","unstructured":"Ha, S. O., Kim, D. Y., Sohn, C. H. & Lim, K. S. Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature. Intern Emerg Med 9, 325\u2013330 (2014).","journal-title":"Intern Emerg Med"},{"key":"29752_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0161-6420(94)31303-0","volume":"101","author":"M Hope-Ross","year":"1994","unstructured":"Hope-Ross, M. et al. Adverse reactions due to indocyanine green. Ophthalmology 101, 529\u2013533 (1994).","journal-title":"Ophthalmology"},{"key":"29752_CR16","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1089\/jop.2011.0221","volume":"28","author":"Z Su","year":"2012","unstructured":"Su, Z., Ye, P., Teng, Y., Zhang, L. & Shu, X. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography. J Ocul Pharmacol Ther 28, 410\u2013413 (2012).","journal-title":"J Ocul Pharmacol Ther"},{"key":"29752_CR17","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1097\/ICO.0000000000000609","volume":"34","author":"V Romano","year":"2015","unstructured":"Romano, V. et al. Angiographic and In Vivo Confocal Microscopic Characterization of Human Corneal Blood and Presumed Lymphatic Neovascularization: A Pilot Study. Cornea 34, 1459\u20131465 (2015).","journal-title":"Cornea"},{"key":"29752_CR18","doi-asserted-by":"publisher","first-page":"e26253","DOI":"10.1371\/journal.pone.0026253","volume":"6","author":"P Steven","year":"2011","unstructured":"Steven, P., Bock, F., Huttmann, G. & Cursiefen, C. Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels. PLoS One 6, e26253 (2011).","journal-title":"PLoS One"},{"key":"29752_CR19","doi-asserted-by":"publisher","unstructured":"Ang, M. et al. Anterior segment optical coherence tomography. Prog Retin Eye Res. pii: S1350-9462(17)30085-X, https:\/\/doi.org\/10.1016\/j.preteyeres.2018.04.002 (2018). [Epub ahead of print] Review. PMID: 29635068.","DOI":"10.1016\/j.preteyeres.2018.04.002"},{"key":"29752_CR20","doi-asserted-by":"publisher","first-page":"e4907","DOI":"10.1097\/MD.0000000000004907","volume":"95","author":"A Wylegala","year":"2016","unstructured":"Wylegala, A., Teper, S., Dobrowolski, D. & Wylegala, E. Optical coherence angiography: A review. Medicine (Baltimore) 95, e4907 (2016).","journal-title":"Medicine (Baltimore)"},{"key":"29752_CR21","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00417-017-3896-2","volume":"256","author":"M Ang","year":"2018","unstructured":"Ang, M. et al. Optical coherence tomography angiography: a review of current and future clinical applications. Graefes Arch Clin Exp Ophthalmol 256, 237\u2013245 (2018).","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"29752_CR22","doi-asserted-by":"crossref","unstructured":"Tan, A. C. S. et al. An overview of the clinical applications of optical coherence tomography angiography. Eye (Lond) (2017).","DOI":"10.1038\/eye.2017.181"},{"key":"29752_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","volume":"133","author":"RF Spaide","year":"2015","unstructured":"Spaide, R. F., Klancnik, J. M. Jr. & Cooney, M. J. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol 133, 45\u201350 (2015).","journal-title":"JAMA Ophthalmol"},{"key":"29752_CR24","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1016\/j.ophtha.2015.05.017","volume":"122","author":"M Ang","year":"2015","unstructured":"Ang, M. et al. Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging. Ophthalmology 122, 1740\u20131747 (2015).","journal-title":"Ophthalmology"},{"key":"29752_CR25","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1136\/bjophthalmol-2015-307338","volume":"100","author":"M Ang","year":"2016","unstructured":"Ang, M. et al. En face optical coherence tomography angiography for corneal neovascularisation. Br J Ophthalmol 100, 616\u2013621 (2016).","journal-title":"Br J Ophthalmol"},{"key":"29752_CR26","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1136\/bjophthalmol-2015-307706","volume":"100","author":"M Ang","year":"2016","unstructured":"Ang, M. et al. Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation. Br J Ophthalmol 100, 1557\u20131563 (2016).","journal-title":"Br J Ophthalmol"},{"key":"29752_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00417-016-3505-9","volume":"255","author":"Y Cai","year":"2017","unstructured":"Cai, Y., Alio Del Barrio, J. L., Wilkins, M. R. & Ang, M. Serial optical coherence tomography angiography for corneal vascularization. Graefes Arch Clin Exp Ophthalmol 255, 135\u2013139 (2017).","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"29752_CR28","doi-asserted-by":"crossref","unstructured":"Ang, M. et al. Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation. Br J Ophthalmol (2017).","DOI":"10.1136\/bjophthalmol-2017-311072"},{"key":"29752_CR29","doi-asserted-by":"publisher","first-page":"Oct27","DOI":"10.1167\/iovs.15-19043","volume":"57","author":"SS Gao","year":"2016","unstructured":"Gao, S. S. et al. Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 57, Oct27\u201336 (2016).","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"29752_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/ICL.0b013e318286bc0f","volume":"39","author":"Y Ye","year":"2013","unstructured":"Ye, Y. et al. Resolution of slit-lamp microscopy photography using various cameras. Eye Contact Lens 39, 205\u2013213 (2013).","journal-title":"Eye Contact Lens"},{"key":"29752_CR31","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/j.1755-3768.2009.01602.x","volume":"88","author":"HM Helb","year":"2010","unstructured":"Helb, H. M. et al. Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography. Acta Ophthalmol 88, 842\u2013849 (2010).","journal-title":"Acta Ophthalmol"},{"key":"29752_CR32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.preteyeres.2014.03.004","volume":"41","author":"RA Leitgeb","year":"2014","unstructured":"Leitgeb, R. A., Werkmeister, R. M., Blatter, C. & Schmetterer, L. Doppler optical coherence tomography. Prog Retin Eye Res 41, 26\u201343 (2014).","journal-title":"Prog Retin Eye Res"},{"key":"29752_CR33","doi-asserted-by":"publisher","first-page":"071412","DOI":"10.1117\/1.JBO.19.7.071412","volume":"19","author":"W Drexler","year":"2014","unstructured":"Drexler, W. et al. Optical coherence tomography today: speed, contrast, and multimodality. J Biomed Opt 19, 071412 (2014).","journal-title":"J Biomed Opt"},{"key":"29752_CR34","doi-asserted-by":"publisher","first-page":"9685297","DOI":"10.1155\/2016\/9685297","volume":"2016","author":"M Ang","year":"2016","unstructured":"Ang, M., Cai, Y. & Tan, A. C. Swept Source Optical Coherence Tomography Angiography for Contact Lens-Related Corneal Vascularization. J Ophthalmol 2016, 9685297 (2016).","journal-title":"J Ophthalmol"},{"key":"29752_CR35","doi-asserted-by":"crossref","unstructured":"Pichi, F. et al. The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. Prog Retin Eye Res (2017).","DOI":"10.1007\/978-3-319-23690-2_8"},{"key":"29752_CR36","first-page":"988","volume":"7","author":"A Guarnieri","year":"2014","unstructured":"Guarnieri, A. et al. Quantification of corneal neovascularization after ex vivo limbal epithelial stem cell therapy. Int J Ophthalmol 7, 988\u2013995 (2014).","journal-title":"Int J Ophthalmol"},{"key":"29752_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0278-1","volume":"16","author":"M Ang","year":"2016","unstructured":"Ang, M., Sng, C. & Milea, D. Optical coherence tomography angiography in dural carotid-cavernous sinus fistula. BMC Ophthalmol 16, 93 (2016).","journal-title":"BMC Ophthalmol"},{"key":"29752_CR38","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1364\/OE.20.004710","volume":"20","author":"Y Jia","year":"2012","unstructured":"Jia, Y. et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20, 4710\u20134725 (2012).","journal-title":"Opt Express"},{"key":"29752_CR39","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.ajo.2010.04.024","volume":"150","author":"JJ Perez-Santonja","year":"2010","unstructured":"Perez-Santonja, J. J., Campos-Mollo, E., Lledo-Riquelme, M., Javaloy, J. & Alio, J. L. Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model. Am J Ophthalmol 150, 519\u2013528 e511 (2010).","journal-title":"Am J Ophthalmol"},{"key":"29752_CR40","doi-asserted-by":"crossref","unstructured":"Sharma, S. et al. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol (2017).","DOI":"10.1136\/bjophthalmol-2016-309245"},{"key":"29752_CR41","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.ophtha.2015.02.012","volume":"122","author":"N Spiteri","year":"2015","unstructured":"Spiteri, N. et al. Corneal angiography for guiding and evaluating fine-needle diathermy treatment of corneal neovascularization. Ophthalmology 122, 1079\u20131084 (2015).","journal-title":"Ophthalmology"},{"key":"29752_CR42","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/jamaophthalmol.2014.3950","volume":"133","author":"RF Spaide","year":"2015","unstructured":"Spaide, R. F., Klancnik, J. M. Jr. & Cooney, M. J. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography. JAMA Ophthalmol 133, 66\u201373 (2015).","journal-title":"JAMA Ophthalmol"},{"key":"29752_CR43","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1242\/bio.012302","volume":"4","author":"Y Uchida","year":"2015","unstructured":"Uchida, Y., James, J. M., Suto, F. & Mukouyama, Y. S. Class 3 semaphorins negatively regulate dermal lymphatic network formation. Biol Open 4, 1194\u20131205 (2015).","journal-title":"Biol Open"},{"key":"29752_CR44","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1111\/febs.13234","volume":"282","author":"J Zhu","year":"2015","unstructured":"Zhu, J. et al. Simultaneous in vivo imaging of blood and lymphatic vessel growth in Prox1-GFP\/Flk1::myr-mCherry mice. FEBS J 282, 1458\u20131467 (2015).","journal-title":"FEBS J"},{"key":"29752_CR45","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archophthalmol.2011.42","volume":"129","author":"D Hos","year":"2011","unstructured":"Hos, D. et al. Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. Arch Ophthalmol 129, 445\u2013452 (2011).","journal-title":"Arch Ophthalmol"},{"key":"29752_CR46","doi-asserted-by":"publisher","first-page":"e26103","DOI":"10.1371\/journal.pone.0026103","volume":"6","author":"W Chen","year":"2011","unstructured":"Chen, W. et al. Corneal alternations induced by topical application of benzalkonium chloride in rabbit. PLoS One 6, e26103 (2011).","journal-title":"PLoS One"},{"key":"29752_CR47","unstructured":"Fu, H. et al. In Proceedings of the Ophthalmic Medical Image Analysis Third International Workshop, OMIA 2016, Held in Conjunction with MICCAI 2016, Athens, Greece. (ed Garvin, M. K., Chen, X., Liu, J., Trucco, E. & Xu, Y.) 158\u2013159."},{"key":"29752_CR48","doi-asserted-by":"publisher","first-page":"e0122332","DOI":"10.1371\/journal.pone.0122332","volume":"10","author":"Y Zhao","year":"2015","unstructured":"Zhao, Y., Liu, Y., Wu, X., Harding, S. P. & Zheng, Y. Retinal vessel segmentation: an efficient graph cut approach with retinex and local phase. PLoS One 10, e0122332 (2015).","journal-title":"PLoS One"},{"key":"29752_CR49","doi-asserted-by":"publisher","first-page":"5604","DOI":"10.1364\/BOE.8.005604","volume":"8","author":"A Li","year":"2017","unstructured":"Li, A., You, J., Du, C. & Pan, Y. Automated segmentation and quantification of OCT angiography for tracking angiogenesis progression. Biomed Opt Express 8, 5604\u20135616 (2017).","journal-title":"Biomed Opt Express"},{"key":"29752_CR50","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/S1051-2004(02)00032-5","volume":"13","author":"OA Basir","year":"2003","unstructured":"Basir, O. A., Belkasim, S. & Ghazal, A. Phase-based optimal image thresholding. Digital Singnal Processing 13, 636\u2013655 (2003).","journal-title":"Digital Singnal Processing"},{"key":"29752_CR51","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1364\/BOE.3.003127","volume":"3","author":"Y Jia","year":"2012","unstructured":"Jia, Y. et al. Quantitative OCT angiography of optic nerve head blood flow. Biomed Opt Express 3, 3127\u20133137 (2012).","journal-title":"Biomed Opt Express"},{"key":"29752_CR52","first-page":"1545","volume":"10","author":"R Mastropasqua","year":"2017","unstructured":"Mastropasqua, R. et al. Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography. Int J Ophthalmol 10, 1545\u20131551 (2017).","journal-title":"Int J Ophthalmol"},{"key":"29752_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-017-0068-9","volume":"3","author":"M Al-Sheikh","year":"2017","unstructured":"Al-Sheikh, M., Ghasemi Falavarjani, K., Akil, H. & Sadda, S. R. Impact of image quality on OCT angiography based quantitative measurements. Int J Retina Vitreous 3, 13 (2017).","journal-title":"Int J Retina Vitreous"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29752-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29752-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29752-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T08:07:09Z","timestamp":1671610029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29752-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["29752"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-29752-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,31]]},"assertion":[{"value":"3 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11493"}}