{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:22:16Z","timestamp":1761844936581,"version":"3.37.3"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>S100P has been shown to be a marker for carcinogenesis where its expression in solid tumours correlates with metastasis and a poor patient prognosis. This protein\u2019s role in any physiological process is, however, unknown. Here we first show that S100P is expressed both in trophoblasts<jats:italic>in vivo<\/jats:italic>as well as in some corresponding cell lines in culture. We demonstrate that S100P is predominantly expressed during the early stage of placental formation with its highest expression levels occurring during the first trimester of gestation, particularly in the invading columns and anchoring villi. Using gain or loss of function studies through overexpression or knockdown of S100P expression respectively, our work shows that S100P stimulates both cell motility and cellular invasion in different trophoblastic and first trimester EVT cell lines. Interestingly, cell invasion was seen to be more dramatically affected than cell migration. Our results suggest that S100P may be acting as an important regulator of trophoblast invasion during placentation. This finding sheds new light on a hitherto uncharacterized molecular mechanism which may, in turn, lead to the identification of novel targets that may explain why significant numbers of confirmed human pregnancies suffer complications through poor placental implantation.<\/jats:p>","DOI":"10.1038\/s41598-018-29852-2","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T10:01:36Z","timestamp":1532512896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["S100P enhances the motility and invasion of human trophoblast cell lines"],"prefix":"10.1038","volume":"8","author":[{"given":"Maral E. A.","family":"Tabrizi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara L.","family":"Lancaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamir M.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Georgiadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankana","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayna J.","family":"Mistry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Rudland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-0475","authenticated-orcid":false,"given":"Shakil","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane R.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"29852_CR1","first-page":"183","volume":"50","author":"X Zhao","year":"2015","unstructured":"Zhao, X., Pan, S. & Liu, C. [Effect of S100 calcium binding protein A12 on the pathogenesis of preeclampsia]. Zhonghua fu chan ke za zhi 50, 183\u2013187 (2015).","journal-title":"Zhonghua fu chan ke za zhi"},{"key":"29852_CR2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.placenta.2014.03.017","volume":"35","author":"E Jurewicz","year":"2014","unstructured":"Jurewicz, E., Kasacka, I., Bankowski, E. & Filipek, A. S100A6 and its extracellular targets in Wharton\u2019s jelly of healthy and preeclamptic patients. Placenta 35, 386\u2013391, https:\/\/doi.org\/10.1016\/j.placenta.2014.03.017 (2014).","journal-title":"Placenta"},{"key":"29852_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.5713\/ajas.2011.11305","volume":"25","author":"Y Choi","year":"2012","unstructured":"Choi, Y., Seo, H., Shim, J., Kim, M. & Ka, H. Regulation of S100G Expression in the Uterine Endometrium during Early Pregnancy in Pigs. Asian-Australasian journal of animal sciences 25, 44\u201351, https:\/\/doi.org\/10.5713\/ajas.2011.11305 (2012).","journal-title":"Asian-Australasian journal of animal sciences"},{"key":"29852_CR4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1530\/rep.1.00226","volume":"128","author":"KC Luu","year":"2004","unstructured":"Luu, K. C. et al. Endometrial expression of calbindin (CaBP)-d28k but not CaBP-d9k in primates implies evolutionary changes and functional redundancy of calbindins at implantation. Reproduction 128, 433\u2013441, https:\/\/doi.org\/10.1530\/rep.1.00226 (2004).","journal-title":"Reproduction"},{"key":"29852_CR5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/19336918.2015.1128623","volume":"10","author":"L Bissonnette","year":"2016","unstructured":"Bissonnette, L. et al. Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype. Cell Adh Migr 10, 282\u2013298, https:\/\/doi.org\/10.1080\/19336918.2015.1128623 (2016).","journal-title":"Cell Adh Migr"},{"key":"29852_CR6","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1210\/jc.2012-2075","volume":"97","author":"XM Liu","year":"2012","unstructured":"Liu, X. M. et al. Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure. The Journal of clinical endocrinology and metabolism 97, 3672\u20133683, https:\/\/doi.org\/10.1210\/jc.2012-2075 (2012).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"29852_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mce.2005.03.002","volume":"236","author":"L Belkacemi","year":"2005","unstructured":"Belkacemi, L., Zuegel, U., Steinmeyer, A., Dion, J. P. & Lafond, J. Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3. Molecular and cellular endocrinology 236, 31\u201341, https:\/\/doi.org\/10.1016\/j.mce.2005.03.002 (2005).","journal-title":"Molecular and cellular endocrinology"},{"key":"29852_CR8","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1095\/biolreprod.102.009373","volume":"68","author":"L Belkacemi","year":"2003","unstructured":"Belkacemi, L., Gariepy, G., Mounier, C., Simoneau, L. & Lafond, J. Expression of calbindin-D28k (CaBP28k) in trophoblasts from human term placenta. Biol Reprod 68, 1943\u20131950, https:\/\/doi.org\/10.1095\/biolreprod.102.009373 (2003).","journal-title":"Biol Reprod"},{"key":"29852_CR9","first-page":"1597","volume":"10","author":"HL Ford","year":"1995","unstructured":"Ford, H. L. & Zain, S. B. Interaction of metastasis associated Mts1 protein with nonmuscle myosin. Oncogene 10, 1597\u20131605 (1995).","journal-title":"Oncogene"},{"key":"29852_CR10","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1021\/pr1010795","volume":"10","author":"C Guzel","year":"2011","unstructured":"Guzel, C. et al. Multiple reaction monitoring assay for pre-eclampsia related calcyclin peptides in formalin fixed paraffin embedded placenta. Journal of proteome research 10, 3274\u20133282, https:\/\/doi.org\/10.1021\/pr1010795 (2011).","journal-title":"Journal of proteome research"},{"key":"29852_CR11","first-page":"1093","volume":"99","author":"E Marinoni","year":"2002","unstructured":"Marinoni, E. et al. Ontogenetic localization and distribution of S-100beta protein in human placental tissues. Obstetrics and gynecology 99, 1093\u20131099 (2002).","journal-title":"Obstetrics and gynecology"},{"key":"29852_CR12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2535\/ofaj1936.76.2-3_123","volume":"76","author":"N Sato","year":"1999","unstructured":"Sato, N., Isono, K., Ishiwata, I., Nakai, M. & Kami, K. Tissue expression of the S100 protein family-related MRP8 gene in human chorionic villi by in situ hybridization techniques. Okajimas folia anatomica Japonica 76, 123\u2013129 (1999).","journal-title":"Okajimas folia anatomica Japonica"},{"key":"29852_CR13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1432-1033.1992.tb17080.x","volume":"207","author":"T Becker","year":"1992","unstructured":"Becker, T., Gerke, V., Kube, E. & Weber, K. S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. Eur J Biochem 207, 541\u2013547 (1992).","journal-title":"Eur J Biochem"},{"key":"29852_CR14","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/0006-291X(92)91865-N","volume":"182","author":"Y Emoto","year":"1992","unstructured":"Emoto, Y., Kobayashi, R., Akatsuka, H. & Hidaka, H. Purification and characterization of a new member of the S-100 protein family from human placenta. Biochem Biophys Res Commun 182, 1246\u20131253 (1992).","journal-title":"Biochem Biophys Res Commun"},{"key":"29852_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-8-2","volume":"8","author":"S Parkkila","year":"2008","unstructured":"Parkkila, S. et al. The calcium-binding protein S100P in normal and malignant human tissues. BMC clinical pathology 8, 2, https:\/\/doi.org\/10.1186\/1472-6890-8-2 (2008).","journal-title":"BMC clinical pathology"},{"key":"29852_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1477-7827-10-106","volume":"10","author":"D Zhang","year":"2012","unstructured":"Zhang, D., Ma, C., Sun, X., Xia, H. & Zhang, W. S100P expression in response to sex steroids during the implantation window in human endometrium. Reproductive biology and endocrinology: RB&E 10, 106, https:\/\/doi.org\/10.1186\/1477-7827-10-106 (2012).","journal-title":"Reproductive biology and endocrinology: RB&E"},{"key":"29852_CR17","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.fertnstert.2009.07.1667","volume":"94","author":"XM Tong","year":"2010","unstructured":"Tong, X. M., Lin, X. N., Song, T., Liu, L. & Zhang, S. Y. Calcium-binding protein S100P is highly expressed during the implantation window in human endometrium. Fertility and sterility 94, 1510\u20131518, https:\/\/doi.org\/10.1016\/j.fertnstert.2009.07.1667 (2010).","journal-title":"Fertility and sterility"},{"key":"29852_CR18","doi-asserted-by":"publisher","unstructured":"Zhou, T., Wang, H., Zhang, S., Jiang, X. & Wei, X. S100P is a potential molecular target of cadmium-induced inhibition of human placental trophoblast cell proliferation. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie, https:\/\/doi.org\/10.1016\/j.etp.2016.09.002 (2016).","DOI":"10.1016\/j.etp.2016.09.002"},{"key":"29852_CR19","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3109\/09513590.2015.1069268","volume":"31","author":"HY Zhu","year":"2015","unstructured":"Zhu, H. Y., Wang, J. X., Tong, X. M., Xue, Y. M. & Zhang, S. Y. S100P regulates trophoblast-like cell proliferation via P38 MAPK pathway. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology 31, 796\u2013800, https:\/\/doi.org\/10.3109\/09513590.2015.1069268 (2015).","journal-title":"Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology"},{"key":"29852_CR20","first-page":"445","volume":"8","author":"HY Zhu","year":"2015","unstructured":"Zhu, H. Y. et al. Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy. International journal of fertility & sterility 8, 445\u2013452 (2015).","journal-title":"International journal of fertility & sterility"},{"key":"29852_CR21","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1161\/CIRCULATIONAHA.113.001631","volume":"127","author":"K Wang","year":"2013","unstructured":"Wang, K. et al. Dysregulation of hydrogen sulfide producing enzyme cystathionine gamma-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. Circulation 127, 2514\u20132522, https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.001631 (2013).","journal-title":"Circulation"},{"key":"29852_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1095\/biolreprod.109.077800","volume":"82","author":"NJ Hannan","year":"2010","unstructured":"Hannan, N. J., Paiva, P., Dimitriadis, E. & Salamonsen, L. A. Models for study of human embryo implantation: choice of cell lines? Biol Reprod 82, 235\u2013245, https:\/\/doi.org\/10.1095\/biolreprod.109.077800 (2010).","journal-title":"Biol Reprod"},{"key":"29852_CR23","doi-asserted-by":"publisher","first-page":"15330","DOI":"10.1074\/jbc.M112.349787","volume":"287","author":"M Du","year":"2012","unstructured":"Du, M. et al. S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. J Biol Chem 287, 15330\u201315344, https:\/\/doi.org\/10.1074\/jbc.M112.349787 (2012).","journal-title":"J Biol Chem"},{"key":"29852_CR24","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"U Laemmli","year":"1970","unstructured":"Laemmli, U. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"29852_CR25","doi-asserted-by":"publisher","first-page":"439","DOI":"10.4161\/cam.5.5.17773","volume":"5","author":"C Goh Then Sin","year":"2011","unstructured":"Goh Then Sin, C. et al. S100A4 downregulates filopodia formation through increased dynamic instability. Cell Adh Migr 5, 439\u2013447, https:\/\/doi.org\/10.4161\/cam.5.5.17773 (2011).","journal-title":"Cell Adh Migr"},{"key":"29852_CR26","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1172\/JCI119881","volume":"101","author":"X Li","year":"1998","unstructured":"Li, X. et al. Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants. The Journal of clinical investigation 101, 442\u2013454, https:\/\/doi.org\/10.1172\/JCI119881 (1998).","journal-title":"The Journal of clinical investigation"},{"key":"29852_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-61779-207-6_4","volume":"769","author":"S Chaubey","year":"2011","unstructured":"Chaubey, S., Ridley, A. J. & Wells, C. M. Using the Dunn chemotaxis chamber to analyze primary cell migration in real time. Methods Mol Biol 769, 41\u201351, https:\/\/doi.org\/10.1007\/978-1-61779-207-6_4 (2011).","journal-title":"Methods Mol Biol"},{"key":"29852_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1369\/jhc.5B6851.2006","volume":"54","author":"SR Shi","year":"2006","unstructured":"Shi, S. R., Liu, C., Balgley, B. M., Lee, C. & Taylor, C. R. Protein extraction from formalin-fixed, paraffin-embedded tissue sections: quality evaluation by mass spectrometry. J Histochem Cytochem 54, 739\u2013743, https:\/\/doi.org\/10.1369\/jhc.5B6851.2006 (2006).","journal-title":"J Histochem Cytochem"},{"key":"29852_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1023\/A:1026311423326","volume":"30","author":"G Jin","year":"2003","unstructured":"Jin, G. et al. Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+ -binding protein. Molecular biology reports 30, 243\u2013248 (2003).","journal-title":"Molecular biology reports"},{"issue":"Suppl A","key":"29852_CR30","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1053\/plac.2001.0647","volume":"22","author":"KT Shiverick","year":"2001","unstructured":"Shiverick, K. T. et al. Cell culture models of human trophoblast II: trophoblast cell lines\u2013a workshop report. Placenta 22(Suppl A), S104\u2013106, https:\/\/doi.org\/10.1053\/plac.2001.0647 (2001).","journal-title":"Placenta"},{"key":"29852_CR31","doi-asserted-by":"publisher","first-page":"29331","DOI":"10.1074\/jbc.M806145200","volume":"283","author":"J Austermann","year":"2008","unstructured":"Austermann, J., Nazmi, A. R., Muller-Tidow, C. & Gerke, V. Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration. J Biol Chem 283, 29331\u201329340, https:\/\/doi.org\/10.1074\/jbc.M806145200 (2008).","journal-title":"J Biol Chem"},{"key":"29852_CR32","doi-asserted-by":"publisher","first-page":"5356","DOI":"10.1158\/1078-0432.CCR-05-0092","volume":"11","author":"T Arumugam","year":"2005","unstructured":"Arumugam, T., Simeone, D. M., Van Golen, K. & Logsdon, C. D. S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res 11, 5356\u20135364, https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-0092 (2005).","journal-title":"Clin Cancer Res"},{"key":"29852_CR33","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1186\/bcr3144","volume":"14","author":"C Zhou","year":"2012","unstructured":"Zhou, C. et al. Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast cancer research: BCR 14, R45, https:\/\/doi.org\/10.1186\/bcr3144 (2012).","journal-title":"Breast cancer research: BCR"},{"key":"29852_CR34","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ceb.2011.11.001","volume":"24","author":"B Wehrle-Haller","year":"2012","unstructured":"Wehrle-Haller, B. Structure and function of focal adhesions. Curr Opin Cell Biol 24, 116\u2013124, https:\/\/doi.org\/10.1016\/j.ceb.2011.11.001 (2012).","journal-title":"Curr Opin Cell Biol"},{"key":"29852_CR35","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/ncb0807-858","volume":"9","author":"R Zaidel-Bar","year":"2007","unstructured":"Zaidel-Bar, R., Itzkovitz, S., Ma\u2019ayan, A., Iyengar, R. & Geiger, B. Functional atlas of the integrin adhesome. Nat Cell Biol 9, 858\u2013867, https:\/\/doi.org\/10.1038\/ncb0807-858 (2007).","journal-title":"Nat Cell Biol"},{"key":"29852_CR36","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1091\/mbc.e02-06-0345","volume":"14","author":"J Magdalena","year":"2003","unstructured":"Magdalena, J. et al. Involvement of the Arp2\/3 complex and Scar2 in Golgi polarity in scratch wound models. Mol Biol Cell 14, 670\u2013684, https:\/\/doi.org\/10.1091\/mbc.E02-06-0345 (2003).","journal-title":"Mol Biol Cell"},{"key":"29852_CR37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-207-6_2","volume":"769","author":"G Cory","year":"2011","unstructured":"Cory, G. Scratch-wound assay. Methods Mol Biol 769, 25\u201330, https:\/\/doi.org\/10.1007\/978-1-61779-207-6_2 (2011).","journal-title":"Methods Mol Biol"},{"key":"29852_CR38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1089\/wound.2011.0352","volume":"2","author":"C Darido","year":"2013","unstructured":"Darido, C. & Jane, S. M. Golgi Feels Its Own Wound. Advances in wound care 2, 87\u201392, https:\/\/doi.org\/10.1089\/wound.2011.0352 (2013).","journal-title":"Advances in wound care"},{"key":"29852_CR39","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.1158\/1078-0432.CCR-06-0298","volume":"12","author":"K Ohuchida","year":"2006","unstructured":"Ohuchida, K. et al. S100P is an early developmental marker of pancreatic carcinogenesis. Clin Cancer Res 12, 5411\u20135416, https:\/\/doi.org\/10.1158\/1078-0432.CCR-06-0298 (2006).","journal-title":"Clin Cancer Res"},{"key":"29852_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/ijc.20376","volume":"112","author":"E Missiaglia","year":"2004","unstructured":"Missiaglia, E. et al. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer 112, 100\u2013112, https:\/\/doi.org\/10.1002\/ijc.20376 (2004).","journal-title":"Int J Cancer"},{"key":"29852_CR41","first-page":"513","volume":"28","author":"A Maciejczyk","year":"2013","unstructured":"Maciejczyk, A. et al. Elevated nuclear S100P expression is associated with poor survival in early breast cancer patients. Histology and histopathology 28, 513\u2013524 (2013).","journal-title":"Histology and histopathology"},{"key":"29852_CR42","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1158\/0008-5472.CAN-05-2605","volume":"66","author":"G Wang","year":"2006","unstructured":"Wang, G. et al. Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients. Cancer Res 66, 1199\u20131207, https:\/\/doi.org\/10.1158\/0008-5472.CAN-05-2605 (2006).","journal-title":"Cancer Res"},{"key":"29852_CR43","first-page":"69","volume":"22","author":"G Rehbein","year":"2008","unstructured":"Rehbein, G., Simm, A., Hofmann, H. S., Silber, R. E. & Bartling, B. Molecular regulation of S100P in human lung adenocarcinomas. International journal of molecular medicine 22, 69\u201377 (2008).","journal-title":"International journal of molecular medicine"},{"key":"29852_CR44","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.ejca.2007.06.010","volume":"43","author":"B Bartling","year":"2007","unstructured":"Bartling, B. et al. S100A2-S100P expression profile and diagnosis of non-small cell lung carcinoma: impairment by advanced tumour stages and neoadjuvant chemotherapy. European journal of cancer 43, 1935\u20131943, https:\/\/doi.org\/10.1016\/j.ejca.2007.06.010 (2007).","journal-title":"European journal of cancer"},{"key":"29852_CR45","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.placenta.2012.11.003","volume":"34","author":"Y Kobayashi","year":"2013","unstructured":"Kobayashi, Y. et al. Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta. Placenta 34, 110\u2013118, https:\/\/doi.org\/10.1016\/j.placenta.2012.11.003 (2013).","journal-title":"Placenta"},{"key":"29852_CR46","doi-asserted-by":"crossref","unstructured":"Benirschke, K., Burton, G. J. & Baergen, R. N. Early Development of the Human Placenta. Vol. \u00bb Pathology of the Human Placenta 41 (Springer Berlin Heidelberg, 2012).","DOI":"10.1007\/978-3-642-23941-0_5"},{"key":"29852_CR47","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.placenta.2015.04.008","volume":"36","author":"N Shan","year":"2015","unstructured":"Shan, N. et al. Lamininalpha4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas. Placenta 36, 809\u2013820, https:\/\/doi.org\/10.1016\/j.placenta.2015.04.008 (2015).","journal-title":"Placenta"},{"key":"29852_CR48","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1530\/REP-14-0052","volume":"148","author":"WL Chang","year":"2014","unstructured":"Chang, W. L. et al. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction 148, 343\u2013352, https:\/\/doi.org\/10.1530\/REP-14-0052 (2014).","journal-title":"Reproduction"},{"key":"29852_CR49","doi-asserted-by":"publisher","first-page":"e502","DOI":"10.1038\/cddis.2013.1","volume":"4","author":"Q Zhang","year":"2013","unstructured":"Zhang, Q. et al. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell death & disease 4, e502, https:\/\/doi.org\/10.1038\/cddis.2013.1 (2013).","journal-title":"Cell death & disease"},{"key":"29852_CR50","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.4049\/jimmunol.163.4.2209","volume":"163","author":"RJ Passey","year":"1999","unstructured":"Passey, R. J. et al. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol 163, 2209\u20132216 (1999).","journal-title":"J Immunol"},{"key":"29852_CR51","doi-asserted-by":"publisher","unstructured":"Szklanna, P. B. et al. Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses and limitations. Proteomics, https:\/\/doi.org\/10.1002\/pmic.201700037 (2017).","DOI":"10.1002\/pmic.201700037"},{"key":"29852_CR52","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1053\/plac.2000.0559","volume":"21","author":"A Blaschitz","year":"2000","unstructured":"Blaschitz, A., Weiss, U., Dohr, G. & Desoye, G. Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening. Placenta 21, 733\u2013741, https:\/\/doi.org\/10.1053\/plac.2000.0559 (2000).","journal-title":"Placenta"},{"issue":"Suppl A","key":"29852_CR53","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1053\/plac.2001.0644","volume":"22","author":"HG Frank","year":"2001","unstructured":"Frank, H. G. et al. Cell culture models of human trophoblast: primary culture of trophoblast\u2013a workshop report. Placenta 22(Suppl A), S107\u2013109, https:\/\/doi.org\/10.1053\/plac.2001.0644 (2001).","journal-title":"Placenta"},{"key":"29852_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2016.12.007","volume":"50","author":"W Abou-Kheir","year":"2017","unstructured":"Abou-Kheir, W., Barrak, J., Hadadeh, O. & Daoud, G. HTR-8\/SVneo cell line contains a mixed population of cells. Placenta 50, 1\u20137, https:\/\/doi.org\/10.1016\/j.placenta.2016.12.007 (2017).","journal-title":"Placenta"},{"key":"29852_CR55","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bbrc.2013.01.075","volume":"432","author":"Y Chen","year":"2013","unstructured":"Chen, Y., Wang, K. & Leach, R. 5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8\/SVneo. Biochem Biophys Res Commun 432, 116\u2013122, https:\/\/doi.org\/10.1016\/j.bbrc.2013.01.075 (2013).","journal-title":"Biochem Biophys Res Commun"},{"key":"29852_CR56","doi-asserted-by":"publisher","first-page":"e21990","DOI":"10.1371\/journal.pone.0021990","volume":"6","author":"T Takao","year":"2011","unstructured":"Takao, T. et al. Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8\/SVneo cell line. PLoS One 6, e21990, https:\/\/doi.org\/10.1371\/journal.pone.0021990 (2011).","journal-title":"PLoS One"},{"key":"29852_CR57","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0012-1606(89)90139-5","volume":"136","author":"PS Rudland","year":"1989","unstructured":"Rudland, P. S., Ollerhead, G. & Barraclough, R. Isolation of simian virus 40-transformed human mammary epithelial stem cell lines that can differentiate to myoepithelial-like cells in culture and in vivo. Developmental biology 136, 167\u2013180 (1989).","journal-title":"Developmental biology"},{"key":"29852_CR58","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1095\/biolreprod62.3.739","volume":"62","author":"BA Kilburn","year":"2000","unstructured":"Kilburn, B. A. et al. Extracellular matrix composition and hypoxia regulate the expression of HLA-G and integrins in a human trophoblast cell line. Biol Reprod 62, 739\u2013747 (2000).","journal-title":"Biol Reprod"},{"key":"29852_CR59","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.placenta.2012.04.003","volume":"33","author":"AR Highet","year":"2012","unstructured":"Highet, A. R., Zhang, V. J., Heinemann, G. K. & Roberts, C. T. Use of Matrigel in culture affects cell phenotype and gene expression in the first trimester trophoblast cell line HTR8\/SVneo. Placenta 33, 586\u2013588, https:\/\/doi.org\/10.1016\/j.placenta.2012.04.003 (2012).","journal-title":"Placenta"},{"key":"29852_CR60","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/humrep\/der412","volume":"27","author":"DK Hapangama","year":"2012","unstructured":"Hapangama, D. K. et al. Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis. Hum Reprod 27, 394\u2013407, https:\/\/doi.org\/10.1093\/humrep\/der412 (2012).","journal-title":"Hum Reprod"},{"key":"29852_CR61","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1091\/mbc.e02-09-0553","volume":"14","author":"M Koltzscher","year":"2003","unstructured":"Koltzscher, M., Neumann, C., Konig, S. & Gerke, V. Ca2+ -dependent binding and activation of dormant ezrin by dimeric S100P. Mol Biol Cell 14, 2372\u20132384, https:\/\/doi.org\/10.1091\/mbc.E02-09-0553 (2003).","journal-title":"Mol Biol Cell"},{"key":"29852_CR62","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00018-013-1400-7","volume":"71","author":"SR Gross","year":"2014","unstructured":"Gross, S. R., Sin, C. G., Barraclough, R. & Rudland, P. S. Joining S100 proteins and migration: for better or for worse, in sickness and in health. Cell Mol Life Sci 71, 1551\u20131579, https:\/\/doi.org\/10.1007\/s00018-013-1400-7 (2014).","journal-title":"Cell Mol Life Sci"},{"key":"29852_CR63","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1530\/rep.1.00976","volume":"132","author":"M Mandl","year":"2006","unstructured":"Mandl, M., Ghaffari-Tabrizi, N., Haas, J., Nohammer, G. & Desoye, G. Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines. Reproduction 132, 159\u2013167, https:\/\/doi.org\/10.1530\/rep.1.00976 (2006).","journal-title":"Reproduction"},{"key":"29852_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/srep21630","volume":"6","author":"YH Chiu","year":"2016","unstructured":"Chiu, Y. H. & Chen, H. GATA3 inhibits GCM1 activity and trophoblast cell invasion. Scientific reports 6, 21630, https:\/\/doi.org\/10.1038\/srep21630 (2016).","journal-title":"Scientific reports"},{"key":"29852_CR65","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/1076029611429785","volume":"18","author":"Q Zhou","year":"2012","unstructured":"Zhou, Q. et al. Effects of tissue factor pathway inhibitor-2 expression on biological behavior of BeWo and JEG-3 cell lines. Clinical and applied thrombosis\/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis\/Hemostasis 18, 526\u2013533, https:\/\/doi.org\/10.1177\/1076029611429785 (2012).","journal-title":"Clinical and applied thrombosis\/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis\/Hemostasis"},{"key":"29852_CR66","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00404-015-3830-y","volume":"293","author":"SE Segerer","year":"2016","unstructured":"Segerer, S. E. et al. The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells. Archives of gynecology and obstetrics 293, 407\u2013414, https:\/\/doi.org\/10.1007\/s00404-015-3830-y (2016).","journal-title":"Archives of gynecology and obstetrics"},{"key":"29852_CR67","doi-asserted-by":"publisher","first-page":"e0153656","DOI":"10.1371\/journal.pone.0153656","volume":"11","author":"H Liang","year":"2016","unstructured":"Liang, H. et al. MSX2 Induces Trophoblast Invasion in Human Placenta. PLoS One 11, e0153656, https:\/\/doi.org\/10.1371\/journal.pone.0153656 (2016).","journal-title":"PLoS One"},{"key":"29852_CR68","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1159\/000363028","volume":"34","author":"RZ Jia","year":"2014","unstructured":"Jia, R. Z. et al. CDX2 enhances HTR-8\/SVneo trophoblast cell invasion by altering the expression of matrix metalloproteinases. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology 34, 628\u2013636, https:\/\/doi.org\/10.1159\/000363028 (2014).","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"29852_CR69","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1369\/jhc.2009.953166","volume":"57","author":"Q Yang","year":"2009","unstructured":"Yang, Q. et al. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem 57, 605\u2013612, https:\/\/doi.org\/10.1369\/jhc.2009.953166 (2009).","journal-title":"J Histochem Cytochem"},{"key":"29852_CR70","doi-asserted-by":"publisher","first-page":"e106725","DOI":"10.1371\/journal.pone.0106725","volume":"9","author":"W Yang","year":"2014","unstructured":"Yang, W., Li, Q. & Pan, Z. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK\/ERK\/MMP-2 signaling pathways via S1P\/S1PR1 axis activation. PLoS One 9, e106725, https:\/\/doi.org\/10.1371\/journal.pone.0106725 (2014).","journal-title":"PLoS One"},{"key":"29852_CR71","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11010-013-1947-5","volume":"389","author":"L Dong","year":"2014","unstructured":"Dong, L. et al. Overexpression of S100P promotes colorectal cancer metastasis and decreases chemosensitivity to 5-FU in vitro. Molecular and cellular biochemistry 389, 257\u2013264, https:\/\/doi.org\/10.1007\/s11010-013-1947-5 (2014).","journal-title":"Molecular and cellular biochemistry"},{"key":"29852_CR72","doi-asserted-by":"publisher","first-page":"20672","DOI":"10.18632\/oncotarget.3967","volume":"6","author":"Z Shen","year":"2015","unstructured":"Shen, Z. et al. Identification of the interplay between SOX9 and S100P in the metastasis and invasion of colon carcinoma. Oncotarget 6, 20672\u201320684, https:\/\/doi.org\/10.18632\/oncotarget.3967 (2015).","journal-title":"Oncotarget"},{"key":"29852_CR73","doi-asserted-by":"publisher","first-page":"709","DOI":"10.2119\/molmed.2011.00008","volume":"17","author":"L Jiang","year":"2011","unstructured":"Jiang, L. et al. Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis. Mol Med 17, 709\u2013716, https:\/\/doi.org\/10.2119\/molmed.2011.00008 (2011).","journal-title":"Mol Med"},{"key":"29852_CR74","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1074\/jbc.M110.135095","volume":"286","author":"A Heil","year":"2011","unstructured":"Heil, A. et al. S100P is a novel interaction partner and regulator of IQGAP1. J Biol Chem 286, 7227\u20137238, https:\/\/doi.org\/10.1074\/jbc.M110.135095 (2011).","journal-title":"J Biol Chem"},{"key":"29852_CR75","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1042\/BCJ20170578","volume":"474","author":"CJ Clarke","year":"2017","unstructured":"Clarke, C. J. et al. Activation of tissue plasminogen activator by metastasis-inducing S100P protein. Biochem J 474, 3227\u20133240, https:\/\/doi.org\/10.1042\/BCJ20170578 (2017).","journal-title":"Biochem J"},{"key":"29852_CR76","doi-asserted-by":"publisher","first-page":"e105423","DOI":"10.1371\/journal.pone.0105423","volume":"9","author":"T Nishimura","year":"2014","unstructured":"Nishimura, T. et al. Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. PLoS One 9, e105423, https:\/\/doi.org\/10.1371\/journal.pone.0105423 (2014).","journal-title":"PLoS One"},{"key":"29852_CR77","doi-asserted-by":"publisher","first-page":"41263","DOI":"10.1074\/jbc.C400352200","volume":"279","author":"MA Conti","year":"2004","unstructured":"Conti, M. A., Even-Ram, S., Liu, C., Yamada, K. M. & Adelstein, R. S. Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem 279, 41263\u201341266, https:\/\/doi.org\/10.1074\/jbc.C400352200 (2004).","journal-title":"J Biol Chem"},{"key":"29852_CR78","doi-asserted-by":"publisher","first-page":"140 e147","DOI":"10.1016\/j.ajog.2012.05.007","volume":"207","author":"M Han","year":"2012","unstructured":"Han, M. et al. Effects of alcohol, lithium, and homocysteine on nonmuscle myosin-II in the mouse placenta and human trophoblasts. American journal of obstetrics and gynecology 207, 140 e147\u2013119, https:\/\/doi.org\/10.1016\/j.ajog.2012.05.007 (2012).","journal-title":"American journal of obstetrics and gynecology"},{"key":"29852_CR79","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1247\/csf.15003","volume":"40","author":"T Watanabe","year":"2015","unstructured":"Watanabe, T., Wang, S. & Kaibuchi, K. IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics. Cell Struct Funct 40, 69\u201377, https:\/\/doi.org\/10.1247\/csf.15003 (2015).","journal-title":"Cell Struct Funct"},{"key":"29852_CR80","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.cellsig.2009.02.023","volume":"21","author":"M Johnson","year":"2009","unstructured":"Johnson, M., Sharma, M. & Henderson, B. R. IQGAP1 regulation and roles in cancer. Cellular signalling 21, 1471\u20131478, https:\/\/doi.org\/10.1016\/j.cellsig.2009.02.023 (2009).","journal-title":"Cellular signalling"},{"key":"29852_CR81","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-0-387-79962-9_4","volume":"148","author":"HC Kwaan","year":"2009","unstructured":"Kwaan, H. C. & McMahon, B. The role of plasminogen-plasmin system in cancer. Cancer treatment and research 148, 43\u201366, https:\/\/doi.org\/10.1007\/978-0-387-79962-9_4 (2009).","journal-title":"Cancer treatment and research"},{"key":"29852_CR82","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4161\/cam.23176","volume":"7","author":"SR Gross","year":"2013","unstructured":"Gross, S. R. Actin binding proteins: Their ups and downs in metastatic life. Cell Adh Migr 7, 199\u2013213 (2013).","journal-title":"Cell Adh Migr"},{"key":"29852_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.111.094698","volume":"86","author":"J Saso","year":"2012","unstructured":"Saso, J., Shields, S. K., Zuo, Y. & Chakraborty, C. Role of Rho GTPases in human trophoblast migration induced by IGFBP1. Biol Reprod 86, 1\u20139, https:\/\/doi.org\/10.1095\/biolreprod.111.094698 (2012).","journal-title":"Biol Reprod"},{"key":"29852_CR84","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/cm.21165","volume":"71","author":"A Ishikawa","year":"2014","unstructured":"Ishikawa, A. et al. Cell fusion mediates dramatic alterations in the actin cytoskeleton, focal adhesions, and E-cadherin in trophoblastic cells. Cytoskeleton 71, 241\u2013256, https:\/\/doi.org\/10.1002\/cm.21165 (2014).","journal-title":"Cytoskeleton"},{"key":"29852_CR85","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.1210\/jc.2002-020550","volume":"87","author":"M Kabir-Salmani","year":"2002","unstructured":"Kabir-Salmani, M. et al. Characterization of morphological and cytoskeletal changes in trophoblast cells induced by insulin-like growth factor-I. The Journal of clinical endocrinology and metabolism 87, 5751\u20135759, https:\/\/doi.org\/10.1210\/jc.2002-020550 (2002).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"29852_CR86","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1006\/dbio.2000.0102","volume":"230","author":"MM Parast","year":"2001","unstructured":"Parast, M. M., Aeder, S. & Sutherland, A. E. Trophoblast giant-cell differentiation involves changes in cytoskeleton and cell motility. Developmental biology 230, 43\u201360, https:\/\/doi.org\/10.1006\/dbio.2000.0102 (2001).","journal-title":"Developmental biology"},{"key":"29852_CR87","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1016\/j.ajpath.2014.08.013","volume":"184","author":"Y Zhou","year":"2014","unstructured":"Zhou, Y. et al. LIMK1 regulates human trophoblast invasion\/differentiation and is down-regulated in preeclampsia. Am J Pathol 184, 3321\u20133331, https:\/\/doi.org\/10.1016\/j.ajpath.2014.08.013 (2014).","journal-title":"Am J Pathol"},{"key":"29852_CR88","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejcb.2011.11.006","volume":"91","author":"A Patel","year":"2012","unstructured":"Patel, A. & Dash, P. R. Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation. Eur J Cell Biol 91, 171\u2013179, https:\/\/doi.org\/10.1016\/j.ejcb.2011.11.006 (2012).","journal-title":"Eur J Cell Biol"},{"key":"29852_CR89","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1210\/me.2007-0243","volume":"22","author":"M Kabir-Salmani","year":"2008","unstructured":"Kabir-Salmani, M. et al. The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts. Molecular endocrinology 22, 707\u2013715, https:\/\/doi.org\/10.1210\/me.2007-0243 (2008).","journal-title":"Molecular endocrinology"},{"key":"29852_CR90","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/molehr\/gah014","volume":"10","author":"M Kabir-Salmani","year":"2004","unstructured":"Kabir-Salmani, M., Shiokawa, S., Akimoto, Y., Sakai, K. & Iwashita, M. The role of alpha(5)beta(1)-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation. Molecular human reproduction 10, 91\u201397 (2004).","journal-title":"Molecular human reproduction"},{"key":"29852_CR91","doi-asserted-by":"publisher","first-page":"e0120616","DOI":"10.1371\/journal.pone.0120616","volume":"10","author":"M Fukumoto","year":"2015","unstructured":"Fukumoto, M., Kurisu, S., Yamada, T. & Takenawa, T. alpha-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS One 10, e0120616, https:\/\/doi.org\/10.1371\/journal.pone.0120616 (2015).","journal-title":"PLoS One"},{"key":"29852_CR92","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.cub.2014.05.023","volume":"24","author":"N Elkhatib","year":"2014","unstructured":"Elkhatib, N. et al. Fascin plays a role in stress fiber organization and focal adhesion disassembly. Current biology: CB 24, 1492\u20131499, https:\/\/doi.org\/10.1016\/j.cub.2014.05.023 (2014).","journal-title":"Current biology: CB"},{"key":"29852_CR93","doi-asserted-by":"publisher","first-page":"e92252","DOI":"10.1371\/journal.pone.0092252","volume":"9","author":"J Zhang","year":"2014","unstructured":"Zhang, J. et al. A small physiological electric field mediated responses of extravillous trophoblasts derived from HTR8\/SVneo cells: involvement of activation of focal adhesion kinase signaling. PLoS One 9, e92252, https:\/\/doi.org\/10.1371\/journal.pone.0092252 (2014).","journal-title":"PLoS One"},{"key":"29852_CR94","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.placenta.2012.08.007","volume":"33","author":"WC Liao","year":"2012","unstructured":"Liao, W. C. et al. Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta 33, 1005\u20131011, https:\/\/doi.org\/10.1016\/j.placenta.2012.08.007 (2012).","journal-title":"Placenta"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29852-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29852-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29852-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T23:16:31Z","timestamp":1693782991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-29852-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":94,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["29852"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-29852-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2018,7,31]]},"assertion":[{"value":"5 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11488"}}