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Fluid resuscitation of trauma patients of a nationwide trauma registry was analysed between 2002 and 2015. Effects of synthetic colloid resuscitation in the pre-hospital setting and emergency department on renal failure, renal replacement therapy and multiple organ failure were analysed among patients with \u22652 days intensive care unit stay, and in-hospital mortality was analysed among all patients. 48,484 patients with mean age of 49 years and mean injury severity score of 23 points were included; 72.3% were male and 95.5% had blunt trauma. Risk-adjusted analyses revealed that patients receiving &gt;1,000\u2009ml synthetic colloids experienced an increase of renal failure and renal replacement therapy rates (OR 1.42 and 1.32, respectively, both <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.006). Any synthetic colloid use was associated with an increased risk of multiple organ failure (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but there was no effect on hospital mortality (<jats:italic>p<\/jats:italic>\u2009=\u20090.594). Between 2002 and 2015 usage of synthetic colloids dropped, likewise did total fluid intake and usage of blood products. The data from this analysis suggests that synthetic colloid resuscitation provides no beneficial effects and might be harmful in patients with severe trauma.<\/jats:p>","DOI":"10.1038\/s41598-018-30053-0","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T11:39:57Z","timestamp":1532605197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthetic colloid resuscitation in severely injured patients: analysis of a nationwide trauma registry (TraumaRegister DGU)"],"prefix":"10.1038","volume":"8","author":[{"given":"Peter","family":"Hilbert-Carius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schwarzkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Reinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane S.","family":"Hartog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Lefering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bernhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3406","authenticated-orcid":false,"given":"Manuel F.","family":"Struck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"30053_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9293","volume":"14","author":"S Finfer","year":"2010","unstructured":"Finfer, S. et al. 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R.L. declares that his institute has an ongoing service agreement with AUC GmbH who is the owner of the TraumaRegister DGU. This agreement includes also the statistical support of scientific analyses of registry data. D.S. declares that he has no conflicts of interest. He is fully employed by the Center for Sepsis Control and Care. The CSCC is funded by the German Ministry of Education and Research (BMBF No. 01EO1502). K.R. declares that he is unpaid chair of the Global Sepsis Alliance that for which CLS Behring is a sponsor, he is a paid advisor of Adrenomed Berlin, Germany and holds equity in InflaRx Jena, Germany. C.S.H. declares that she is partially employed by the MidGerman Sepsis Cohort (MSC) which receives funding by the Integrated Research and Treatment Center - Center for Sepsis Control and Care (CSCC) at the Jena University Hospital and the Rudolf Presl GmbH, Kreischa. The CSCC is funded by the German Ministry of Education and Research (BMBF No. 01EO1502). The remaining authors have disclosed that they do not have any conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11567"}}