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Zinc pyrithione (ZPT) has been used as an ingredient in anti-dandruff treatments. The mechanism of ZPT has been investigated in several studies; however, a non-pathogenic model yeast, such as\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    was most often used. The aim of the present study was to understand how ZPT inhibits the growth of\n                    <jats:italic>M. restricta<\/jats:italic>\n                    . We analyzed the cellular metal content and transcriptome profile of ZPT-treated\n                    <jats:italic>M. restricta<\/jats:italic>\n                    cells and found that ZPT treatment dramatically increased cellular zinc levels, along with a small increase in cellular copper levels. Moreover, our transcriptome analysis showed that ZPT inhibits Fe-S cluster synthesis in\n                    <jats:italic>M. restricta<\/jats:italic>\n                    . We also observed that ZPT treatment significantly reduced the expression of lipases, whose activities contribute to the survival and virulence of\n                    <jats:italic>M. restricta<\/jats:italic>\n                    on human skin. Therefore, the results of our study suggest that at least three inhibitory mechanisms are associated with the action of ZPT against\n                    <jats:italic>M. restricta<\/jats:italic>\n                    : (i) an increase in cellular zinc levels, (ii) inhibition of mitochondrial function, and (iii) a decrease in lipase expression.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-30588-2","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T05:36:27Z","timestamp":1533706587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Understanding the Mechanism of Action of the Anti-Dandruff Agent Zinc Pyrithione against Malassezia restricta"],"prefix":"10.1038","volume":"8","author":[{"given":"Minji","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Joon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-0233","authenticated-orcid":false,"given":"Won Hee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"30588_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/j.1468-2494.2012.00723.x","volume":"34","author":"GA Turner","year":"2012","unstructured":"Turner, G. 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