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Selective toxicity against filarial parasites and non-toxic nature in rat model were found as unique traits of <jats:italic>8l<\/jats:italic> to be a future medicine. Taken <jats:italic>en masse<\/jats:italic>, this maiden report on a novel quinolone fused cyclic sulfonamide presents a promising therapeutic lead for lymphatic filariasis in future.<\/jats:p>","DOI":"10.1038\/s41598-018-30610-7","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T18:18:18Z","timestamp":1533665898000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent"],"prefix":"10.1038","volume":"8","author":[{"given":"Suprabhat","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhilesh","family":"Joardar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shovan","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Schiefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Pfarr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi P. 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