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However, its <jats:italic>in vivo<\/jats:italic> relevance is unclear as the phenotype of unstressed HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice is unremarkable. To determine the impact of HSPB1 in injury, HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> and wild type (WT) mice were subjected to cecal ligation and puncture, a model of polymicrobial sepsis. Ten-day mortality was significantly higher in HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice following the onset of sepsis (65% vs. 35%). <jats:italic>Ex vivo<\/jats:italic> mechanical testing revealed that common carotid arteries from HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice were more compliant than those in WT mice over pressures of 50\u2013120\u2009mm Hg. Septic HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice also had increased peritoneal levels of IFN-\u03b3 and decreased systemic levels of IL-6 and KC. There were no differences in frequency of either splenic CD4<jats:sup>+<\/jats:sup> or CD8<jats:sup>+<\/jats:sup> T cells, nor were there differences in apoptosis in either cell type. However, splenic CD4<jats:sup>+<\/jats:sup> T cells and CD8<jats:sup>+<\/jats:sup> T cells from HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice produced significantly less TNF and IL-2 following <jats:italic>ex vivo<\/jats:italic> stimulation. Systemic and local bacterial burden was similar in HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> and WT mice. Thus while HSPB1<jats:sup>\u2212\/\u2212<\/jats:sup> mice are uncompromised under basal conditions, HSPB1 has a critical function <jats:italic>in vivo<\/jats:italic> in sepsis, potentially mediated through alterations in arterial compliance and the immune response.<\/jats:p>","DOI":"10.1038\/s41598-018-30752-8","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T09:25:28Z","timestamp":1534325128000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The small heat shock protein HSPB1 protects mice from sepsis"],"prefix":"10.1038","volume":"8","author":[{"given":"Elise R.","family":"Breed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyam","family":"Yoseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M.","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7797-9291","authenticated-orcid":false,"given":"Luke P.","family":"Brewster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Rudolph L.","family":"Gleason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-808X","authenticated-orcid":false,"given":"Tej K.","family":"Pandita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy L.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton R.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Coopersmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"30752_CR1","doi-asserted-by":"crossref","unstructured":"Ikwegbue, P. 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