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To assess a related mechanism, a 345-channel protein\/DNA array and transcriptional activity ELISA were performed to compare the TF activities in the cisplatin-sensitive SKOV3 and cisplatin-resistant SKOV3-DDP cells and in HO-8910 and the homologous highly metastatic HO-8910PM cells. In SKOV3-DDP <jats:italic>vs<\/jats:italic>. SKOV3 cells, 43 TFs were up-regulated, while 31 were down-regulated. In HO-8910PM <jats:italic>vs<\/jats:italic>. HO-8910 cells, 13 TFs were up-regulated, while 18 were down-regulated. In these two models, 4 TFs (<jats:italic>HOXD8(1), HOXD8(2), RB, RFX1\/2\/3<\/jats:italic>) were simultaneously up-regulated, and 9 TFs (<jats:italic>SRE, FKHR, Angiotensinogen ANG-IRE, Pax2, CD28RC\/NF-IL2B, HLF, CPE, CBFB and c-Ets-1<\/jats:italic>) were down-regulated. <jats:italic>HOXD8<\/jats:italic> mRNA and protein expression levels measured by reverse transcription polymerase chain reaction and ELISA, respectively, were significantly higher in SKOV3-DDP and HO-8910PM than in their corresponding cell lines (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In 52 cases of different ovarian disease, the patients with recurrent and cisplatin-resistant ovarian cancer had higher expression levels of HOXD8 than patients with primary malignant tumours (<jats:italic>p<\/jats:italic>\u2009=\u20090.018, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) or benign tumours (<jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Taken together, these results suggest that <jats:italic>HOXD8<\/jats:italic> is potentially associated with both cisplatin resistance and metastasis in advanced ovarian cancer.<\/jats:p>","DOI":"10.1038\/s41598-018-31030-3","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T15:25:17Z","timestamp":1535988317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-6091","authenticated-orcid":false,"given":"PengMing","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YiYi","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DaBin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GuiFen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoDan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BinHua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Ioana","family":"Braicu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalid","family":"Sehouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"31030_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal, A. et al. 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