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Aim of our study was to address the methodology of short-term BPV assessment and its reduction by Lercanidipine (L) or Enalapril (E) and their combination, through analysis of 24-hour ambulatory BP recordings from two studies including subjects of different age. Study-1: 64 middle-age hypertensives (52.9\u2009\u00b1\u20099.5\u2009yrs) received L and E s.i.d. at 10\u2009mg (L10, E10) or 20\u2009mg doses (L20, E20) for 8 weeks. Study-2: 66 elderly hypertensives (65.5\u2009\u00b1\u20094.7\u2009yrs) received placebo, L10, E20 and L10\u2009+\u2009E20 s.i.d. for 4 weeks. In middle-age subjects, both L and E decreased mean BP and, at the highest dose, also short-term BPV. In elderly subjects, L10 alone or in combination with E20 reduced BPV. Treatment-induced reductions in BP levels and BPV were uncorrelated. Different methods for short-term BPV assessment did not always provide superimposable results in the elderly. Our study supports a better reduction of BPV by L in the elderly and by E\u2009+\u2009L combination at any age, suggesting BPV reduction to be independent from reduction in average BP.<\/jats:p>","DOI":"10.1038\/s41598-018-31746-2","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T14:05:31Z","timestamp":1536329131000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects on 24-hour blood pressure variability of ace-inhibition and calcium channel blockade as monotherapy or in combination"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-7439","authenticated-orcid":false,"given":"Gianfranco","family":"Parati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-2605","authenticated-orcid":false,"given":"Paolo","family":"Castiglioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-2096","authenticated-orcid":false,"given":"Stefano","family":"Omboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-8234","authenticated-orcid":false,"given":"Andrea","family":"Faini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,13]]},"reference":[{"key":"31746_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrcardio.2013.1","volume":"10","author":"G Parati","year":"2013","unstructured":"Parati, G., Ochoa, J. 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