{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:28Z","timestamp":1793726068259,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81302295"],"award-info":[{"award-number":["No.81302295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81270749"],"award-info":[{"award-number":["No. 81270749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81571397"],"award-info":[{"award-number":["No. 81571397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The potential effects of high basal luteinizing hormone (LH) levels on human reproduction were controversial. To demonstrate the effects of elevated basal LH levels on the outcome of patients undergoing\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) cycles, we performed a retrospective data analysis of 1011 polycystic ovarian syndrome (PCOS) patients treated with human menopausal gonadotropin and medroxyprogesterone acetate (hMG\u2009+\u2009MPA) protocol at our center between Nov. 2013 and Jun. 2017. PCOS patients with elevated basal LH levels had significantly higher LH exposure during the stimulation period. The group with LH\u2009\u2265\u200910 mIU\/mL showed a lower mean total hMG dose used but higher numbers of oocytes retrieved, metaphase II oocytes, embryos and top-quality embryos developed than the groups with lower basal LH levels. Moreover, partial correlation analysis showed that the basal LH level was negatively correlated with the total hMG dose but positively correlated with the numbers of oocytes retrieved, metaphase II oocytes, embryos, and top-quality embryos. There were no significant differences in the rates of oocyte retrieval, fertilization, implantation, clinical pregnancy and miscarriage between the groups based on frozen embryo transfer (FET). We concluded that elevated basal LH level does not impair the final outcome of hMG\u2009+\u2009MPA-treated IVF\/ICSI cycles in PCOS women.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-32128-4","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:05:56Z","timestamp":1536563156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles"],"prefix":"10.1038","volume":"8","author":[{"given":"Lihua","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-4401","authenticated-orcid":false,"given":"Qiuju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"32128_CR1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/humrep\/dei348","volume":"21","author":"EM Kolibianakis","year":"2006","unstructured":"Kolibianakis, E. M. et al. Effect of oral contraceptive pill pretreatment on ongoing pregnancy rates in patients stimulated with GnRH antagonists and recombinant FSH for IVF. A randomized controlled trial. Human reproduction. 21, 352\u2013357 (2006).","journal-title":"Human reproduction."},{"key":"32128_CR2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S0015-0282(98)00333-1","volume":"70","author":"MM Biljan","year":"1998","unstructured":"Biljan, M. M. et al. Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates. Fertility and sterility. 70, 1063\u20131069 (1998).","journal-title":"Fertility and sterility."},{"key":"32128_CR3","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1093\/humrep\/12.11.2359","volume":"12","author":"MA Damario","year":"1997","unstructured":"Damario, M. A., Barmat, L., Liu, H. C., Davis, O. K. & Rosenwaks, Z. Dual suppression with oral contraceptives and gonadotrophin releasing-hormone agonists improves in-vitro fertilization outcome in high responder patients. Human reproduction. 12, 2359\u20132365 (1997).","journal-title":"Human reproduction."},{"key":"32128_CR4","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/nrendo.2014.102","volume":"10","author":"CN Jayasena","year":"2014","unstructured":"Jayasena, C. N. & Franks, S. The management of patients with polycystic ovary syndrome. Nature reviews. Endocrinology. 10, 624\u2013636 (2014).","journal-title":"Nature reviews. Endocrinology."},{"key":"32128_CR5","first-page":"755","volume":"18","author":"ZM Van der Spuy","year":"2004","unstructured":"Van der Spuy, Z. M. & Dyer, S. J. The pathogenesis of infertility and early pregnancy loss in polycystic ovary syndrome. Best practice & research. Clinical obstetrics & gynaecology. 18, 755\u2013771 (2004).","journal-title":"Clinical obstetrics & gynaecology."},{"key":"32128_CR6","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1136\/bmj.297.6655.1027","volume":"297","author":"M Sagle","year":"1988","unstructured":"Sagle, M. et al. Recurrent early miscarriage and polycystic ovaries. Bmj. 297, 1027\u20131028 (1988).","journal-title":"Bmj."},{"key":"32128_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S0015-0282(02)04920-8","volume":"79","author":"EM Kolibianakis","year":"2003","unstructured":"Kolibianakis, E. M. et al. Exposure to high levels of luteinizing hormone and estradiol in the early follicular phase of gonadotropin-releasing hormone antagonist cycles is associated with a reduced chance of pregnancy. Fertility and sterility. 79, 873\u2013880 (2003).","journal-title":"Fertility and sterility."},{"key":"32128_CR8","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1093\/humrep\/17.12.3129","volume":"17","author":"J Tesarik","year":"2002","unstructured":"Tesarik, J. & Mendoza, C. Effects of exogenous LH administration during ovarian stimulation of pituitary down-regulated young oocyte donors on oocyte yield and developmental competence. Human reproduction. 17, 3129\u20133137 (2002).","journal-title":"Human reproduction."},{"key":"32128_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.fertnstert.2004.07.969","volume":"83","author":"F Lisi","year":"2005","unstructured":"Lisi, F. et al. Evaluation of two doses of recombinant luteinizing hormone supplementation in an unselected group of women undergoing follicular stimulation for in vitro fertilization. Fertility and sterility. 83, 309\u2013315 (2005).","journal-title":"Fertility and sterility."},{"key":"32128_CR10","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1093\/humrep\/del284","volume":"21","author":"AN Andersen","year":"2006","unstructured":"Andersen, A. N., Devroey, P. & Arce, J. C. Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Human reproduction. 21, 3217\u20133227 (2006).","journal-title":"Human reproduction."},{"key":"32128_CR11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.fertnstert.2008.07.1735","volume":"92","author":"A Weghofer","year":"2009","unstructured":"Weghofer, A. et al. The impact of LH-containing gonadotropin stimulation on euploidy rates in preimplantation embryos: antagonist cycles. Fertility and sterility. 92, 937\u2013942 (2009).","journal-title":"Fertility and sterility."},{"key":"32128_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.fertnstert.2015.03.022","volume":"104","author":"Y Kuang","year":"2015","unstructured":"Kuang, Y. et al. Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. Fertility and sterility. 104, 62\u201370 e63 (2015).","journal-title":"Fertility and sterility."},{"key":"32128_CR13","doi-asserted-by":"crossref","unstructured":"Massin, N. New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF. Human reproduction update (2017).","DOI":"10.1093\/humupd\/dmw047"},{"key":"32128_CR14","doi-asserted-by":"publisher","first-page":"e2939","DOI":"10.1097\/MD.0000000000002939","volume":"95","author":"Y Wang","year":"2016","unstructured":"Wang, Y. et al. Controlled Ovarian Stimulation Using Medroxyprogesterone Acetate and hMG in Patients With Polycystic Ovary Syndrome Treated for IVF: A Double-Blind Randomized Crossover Clinical Trial. Medicine. 95, e2939 (2016).","journal-title":"Medicine."},{"key":"32128_CR15","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1093\/humrep\/15.11.2333","volume":"15","author":"RM Janssens","year":"2000","unstructured":"Janssens, R. M. et al. Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study. Human reproduction. 15, 2333\u20132340 (2000).","journal-title":"Human reproduction."},{"key":"32128_CR16","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0015-0282(01)01973-2","volume":"76","author":"LG Westergaard","year":"2001","unstructured":"Westergaard, L. G., Erb, K., Laursen, S. B., Rex, S. & Rasmussen, P. E. Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study. Fertility and sterility. 76, 543\u2013549 (2001).","journal-title":"Fertility and sterility."},{"key":"32128_CR17","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1093\/humrep\/deh357","volume":"19","author":"JA Huirne","year":"2004","unstructured":"Huirne, J. A. et al. 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Luteal-phase ovarian stimulation is feasible for producing competent oocytes in women undergoing in vitro fertilization\/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in frozen-thawed embryo transfer cycles. Fertility and sterility. 101, 105\u2013111 (2014).","journal-title":"Fertility and sterility."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-32128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-32128-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-32128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T04:33:47Z","timestamp":1671597227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-32128-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["32128"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-32128-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]},"assertion":[{"value":"26 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"13835"}}