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Kansai Medical University"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08224","16K08533","16K10483"],"award-info":[{"award-number":["15K08224","16K08533","16K10483"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["S1101034","S1201038"],"award-info":[{"award-number":["S1101034","S1201038"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bilateral adrenalectomy forces the patient to undergo glucocorticoid replacement therapy and bear a lifetime risk of adrenal crisis. Adrenal autotransplantation is considered useful to avoid adrenal crisis and glucocorticoid replacement therapy. However, the basic process of regeneration in adrenal autografts is poorly understood. Here, we investigated the essential regeneration factors in rat adrenocortical autografts, with a focus on the factors involved in adrenal development and steroidogenesis, such as Hh signalling. A remarkable renewal in cell proliferation and increase in <jats:italic>Cyp11b1<\/jats:italic>, which encodes 11-beta-hydroxylase, occurred in adrenocortical autografts from 2\u20133 weeks after autotransplantation. Serum corticosterone and adrenocorticotropic hormone levels were almost recovered to sham level at 4 weeks after autotransplantation. The adrenocortical autografts showed increased <jats:italic>Dhh<\/jats:italic> expression at 3 weeks after autotransplantation, but not <jats:italic>Shh<\/jats:italic>, which is the only Hh family member to have been reported to be expressed in the adrenal gland. Increased <jats:italic>Gli1<\/jats:italic> expression was also found in the regenerated capsule at 3 weeks after autotransplantation. <jats:italic>Dhh<\/jats:italic> and <jats:italic>Gli1<\/jats:italic> might function in concert to regenerate adrenocortical autografts. This is the first report to clearly show <jats:italic>Dhh<\/jats:italic> expression and its elevation in the adrenal gland.<\/jats:p>","DOI":"10.1038\/s41598-018-32870-9","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T14:26:55Z","timestamp":1537799215000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats"],"prefix":"10.1038","volume":"8","author":[{"given":"Nae","family":"Takizawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souichi","family":"Oe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"32870_CR1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1210\/en.2008-0667","volume":"150","author":"P Ye","year":"2009","unstructured":"Ye, P., Nakamura, Y., Lalli, E. & Rainey, W. 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