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It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditions present a challenge. Here, we focused on the development of a synthetic bone substitute material with local diminishing effects on osteoporosis. Composites were created using calcium phosphate cement (CPC; 60\u2009wt%) and polylactic-co-glycolic acid (PLGA; 40\u2009wt%), which were loaded with alendronate (ALN). <jats:italic>In vitro<\/jats:italic> results showed that ALN-loaded CPC\/PLGA composites presented clinically suitable properties, including setting times, appropriate compressive strength, and controlled release of ALN, the latter being dependent on composite degradation. Using a rat femoral condyle bone defect model in osteoporotic animals, ALN-loaded CPC\/PLGA composites demonstrated stimulatory effects on bone formation both within and outside the defect region.<\/jats:p>","DOI":"10.1038\/s41598-018-33692-5","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T13:48:24Z","timestamp":1539352104000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions"],"prefix":"10.1038","volume":"8","author":[{"given":"Claire I. 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