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Notably, the t(12;21) translocation leading to an <jats:italic>ETV6<\/jats:italic>-AML1 fusion gene is the most common genetic alteration found in childhood acute lymphoblastic leukemia. Moreover, most of these patients also lack <jats:italic>ETV6<\/jats:italic> expression, suggesting a tumor suppressor function. To gain insights on <jats:italic>ETV6<\/jats:italic> DNA-binding specificity and genome wide transcriptional regulation capacities, we performed chromatin immunoprecipitation experiments coupled to deep sequencing in a t(12;21)-positive pre-B leukemic cell line. This strategy led to the identification of <jats:italic>ETV6<\/jats:italic>-bound regions that were further associated to gene expression. <jats:italic>ETV6<\/jats:italic> binding is mostly cell type-specific as only few regions are shared with other blood cell subtypes. Peaks localization and motif enrichment analyses revealed that this unique binding profile could be associated with the <jats:italic>ETV6<\/jats:italic>-AML1 fusion protein specific to the t(12;21) background. This study underscores the complexity of <jats:italic>ETV6<\/jats:italic> binding and uncovers <jats:italic>ETV6<\/jats:italic> transcriptional network in pre-B leukemia cells bearing the recurrent t(12;21) translocation.<\/jats:p>","DOI":"10.1038\/s41598-018-33947-1","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T13:57:55Z","timestamp":1539611875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genome wide mapping of ETV6 binding sites in pre-B leukemic cells"],"prefix":"10.1038","volume":"8","author":[{"given":"Benjamin","family":"Neveu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3733-5723","authenticated-orcid":false,"given":"Maxime","family":"Caron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Lagac\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Richer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-6676","authenticated-orcid":false,"given":"Daniel","family":"Sinnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"33947_CR1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3109\/10409238.2013.838202","volume":"48","author":"A Kar","year":"2013","unstructured":"Kar, A. & Gutierrez-Hartmann, A. 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