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We report safe and efficient approach for transdermal systemic folate delivery using fluidising liposomes (120\u2009\u00b1\u20094\u2009nm) stabilised within 3D matrix of naturally occurring cosmetic bases: Fuller\u2019s earth and henna with room temperature stability. The proof of stratum corneum fluidisation was established <jats:italic>ex-vivo<\/jats:italic> by Langmuir-Blodgett film, FTIR and confocal imaging in rat skin. <jats:italic>In-vivo<\/jats:italic> topical application in rats showed 11-fold increase in plasma folate within 2\u2009hr, confirming systemic delivery through skin. Efficacy study in folate deficient rats over 4 weeks showed significantly higher plasma levels compared to oral delivery with significant skin depot. Sub-acute toxicity studies in rats at 750-fold higher doses showed safety after 4 weeks daily application. Primary irritation patch test on 25 healthy human volunteers proved non-irritant nature of the nutricosmetics. The technology is first demonstration of transdermal folate fortification with nanosized liposome incorporated in cosmetics, without synthetic surfactants\/ethanol or need of external energy. The platform technology opens the possibility of delivering multiple nutrients systemically through skin and can be scaled for affordable community fortification.<\/jats:p>","DOI":"10.1038\/s41598-018-34205-0","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T10:55:16Z","timestamp":1540464916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Stable Liposome in Cosmetic Platforms for Transdermal Folic acid delivery for fortification and treatment of micronutrient deficiencies"],"prefix":"10.1038","volume":"8","author":[{"given":"Mudra Saurabh","family":"Kapoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisha","family":"D\u2019Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorjahan","family":"Aibani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi Sivasankaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Sandbhor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durga","family":"kumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinti","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"key":"34205_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1001\/jama.2017.4413","volume":"317","author":"K Bibbins-Domingo","year":"2017","unstructured":"Bibbins-Domingo, K. et al. 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The authors have patents with this technology, US patent 9375388 and Indian Patent granted.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"16122"}}