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Its protein product, a mitotic kinesin, accelerates growth of normal mammary epithelial cells <jats:italic>in vitro<\/jats:italic> and retinoblastoma tumours in a mouse model, while <jats:italic>KIF14<\/jats:italic> knockdown blocks growth of brain, liver, ovarian, breast, prostate, and other tumour cells and xenografts. However, the tumour-initiating effects of <jats:italic>Kif14<\/jats:italic> overexpression have not been studied. We aged a cohort of <jats:italic>Kif14<\/jats:italic>-overexpressing transgenic mice and wild-type littermates and documented survival, cause of death, and tumour burden. The <jats:italic>Kif14<\/jats:italic> transgene was expressed in all tissues examined, and was associated with increased proliferation marker expression. Neither mouse weights nor overall survival differed between genotypes. However, <jats:italic>Kif14<\/jats:italic> transgenic mice showed a higher incidence of fatal lymphomas (73 vs. 50%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03, Fisher\u2019s exact test), primarily follicular and diffuse B-cell lymphomas. Non-tumour findings included a bilateral ballooning degeneration of lens in 12% of <jats:italic>Kif14<\/jats:italic> transgenic mice but no wild-type mice (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Overall, this work reveals a novel association of <jats:italic>Kif14<\/jats:italic> overexpression with lymphoma but suggests that <jats:italic>Kif14<\/jats:italic> does not have as prominent a role in initiating cancer in other cell types as it does in accelerating tumour development in response to other oncogenic insults.<\/jats:p>","DOI":"10.1038\/s41598-018-34603-4","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T09:24:13Z","timestamp":1540545853000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14"],"prefix":"10.1038","volume":"8","author":[{"given":"Kamakshi","family":"Sishtla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Pitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Shadmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"O\u2019Hare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania S.","family":"Sulaiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony L.","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Condon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Pollok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Sandusky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-7875","authenticated-orcid":false,"given":"Timothy W.","family":"Corson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"34603_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/bjc.2015.264","volume":"113","author":"G Chandrasekaran","year":"2015","unstructured":"Chandrasekaran, G., Tatrai, P. & Gergely, F. 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