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To address the question whether BD represents a specific pathological feature and whether it is linked to a distinct disease condition we studied 62 autopsy cases. BD inclusions exhibited an immunohistochemical staining pattern related to glycosylated, \u03b4- or \u03b7-secretase-derived N-terminal cleavage products of the amyloid precursor protein (sAPP\u03b4\/\u03b7) or shorter fragments of sAPP\u03b7. BD aggregates were found in the myocardium of both ventricles and atria with highest amounts in the atria and lowest in the interventricular septum. The frequency of BD-lesions correlated with age, degree of myocardial fibrosis in individuals with arterial hypertension, and the severity of cerebral amyloid angiopathy (CAA). The intracytoplasmic deposition of N-terminal sAPP\u03b4\/\u03b7 fragments in BD indicates a specific inclusion body pathology related to APP metabolism. 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