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However, little is known how the immune system responds to <jats:italic>C. krusei<\/jats:italic>. Particularly, the molecular mechanisms of the interplay between <jats:italic>C. krusei<\/jats:italic> mannan and DCs remain to be elucidated. We investigated how <jats:italic>C. krusei<\/jats:italic> mannan affected DC responses in comparison to <jats:italic>C. albicans<\/jats:italic>, <jats:italic>C. tropicalis<\/jats:italic> and <jats:italic>C. glabrata<\/jats:italic> mannan. Our results showed that only <jats:italic>C. krusei<\/jats:italic> mannan induced massive cytokine responses in DCs, and led to apoptosis. Although <jats:italic>C. krusei<\/jats:italic> mannan-activated DCs underwent apoptosis, they were still capable of initiating Th17 response. <jats:italic>C. krusei<\/jats:italic> mannan-mediated DC apoptosis was obligated to the TLR2 and MyD88 pathway. These pathways also controlled Th1\/Th17 switching possibly by virtue of the production of the polarizing cytokines IL-12 and IL-6 by the <jats:italic>C. krusei<\/jats:italic> mannan activated-DCs. Our study suggests that TLR2 and MyD88 pathway in DCs are dominant for <jats:italic>C. krusei<\/jats:italic> mannan recognition, which differs from the previous reports showing a crucial role of C-type lectin receptors in <jats:italic>Candida<\/jats:italic> mannan sensing.<\/jats:p>","DOI":"10.1038\/s41598-018-35101-3","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T14:22:00Z","timestamp":1542205320000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2\/MyD88-dependent pathway"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-7299","authenticated-orcid":false,"given":"Thu Ngoc Yen","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panuwat","family":"Padungros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panachai","family":"Wongsrisupphakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noppadol","family":"Sa-Ard-Iam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangsini","family":"Mahanonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranart","family":"Matangkasombut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-7539","authenticated-orcid":false,"given":"Min-Kyung","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharee","family":"Ritprajak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"35101_CR1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/QCO.0000000000000411","volume":"30","author":"AL Colombo","year":"2017","unstructured":"Colombo, A. 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