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We e-activated subretinally the surviving degenerated photoreceptors (d-Phrs) of the <jats:italic>rd1<\/jats:italic> mouse (RP model) and evoked visual responses in the blind retina. The e-stimulation was applied with a single platinum\/iridium electrode. The d-Phrs (calcium-imaging) and ganglion cells (GC) activity (MEA-recording) were recorded in simultaneous multilayer recordings. The findings of this study confirm that the d-Phrs responded to e-stimulation and modulated the retinal network-activity. The application of blockers revealed that the synaptic interactions were dependent on voltage-gated calcium channels and mediated by the transmitters glutamate and GABA. Moreover, the gap junctions coupled networks promoted the lateral-spread of the e-evoked activity in the outer (~60\u2009\u00b5m) and inner (~120\u2009\u00b5m) retina. The activated GCs were identified as subtypes of the ON, OFF and ON-OFF classes. In conclusion, d-Phrs are the ideal interface partners for implants to elicit enhanced visual responses at higher temporal and spatial resolution. Furthermore, the retina\u2019s intact circuity at the onset of complete blindness makes it a tempting target when considering the implantation of implants into young patients to provide a seamless transition from blinding to chip-aided vision.<\/jats:p>","DOI":"10.1038\/s41598-018-35296-5","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T11:13:32Z","timestamp":1542107612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Electrical activation of degenerated photoreceptors in blind mouse retina elicited network-mediated responses in different types of ganglion cells"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-9780","authenticated-orcid":false,"given":"Wadood","family":"Haq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Dietter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhart","family":"Zrenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"35296_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1126\/science.1190897","volume":"329","author":"V Busskamp","year":"2010","unstructured":"Busskamp, V. et al. 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E.Z., the inventor of patents concerning electrical subretinal implants held by Retina Implant A.G. (Reutlingen, Germany), declares no conflict of interests. We additionally confirm that Retina Implant A.G. has neither been involved in the planning of this project nor has it provided goods, services or finances to it, nor has it received or will receive, information on the results of this project beyond what has or will become public.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"16998"}}