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Beyond synapse organization and function, little is known about other roles Neurexins might have in the nervous system. Here we report novel phenotypic consequences of mutations in <jats:italic>Drosophila neurexin<\/jats:italic> (<jats:italic>dnrx<\/jats:italic>), which alters axonal microtubule organization and transport. We show that <jats:italic>dnrx<\/jats:italic> mutants display phenotypic similarities with the BMP receptor <jats:italic>wishful thinking<\/jats:italic> (<jats:italic>wit<\/jats:italic>) and one of the downstream effectors, <jats:italic>futsch<\/jats:italic>, which is a known regulator of microtubule organization and stability. <jats:italic>dnrx<\/jats:italic> has genetic interactions with <jats:italic>wit<\/jats:italic> and <jats:italic>futsch<\/jats:italic>. Loss of Dnrx also results in reduced levels of other downstream effectors of BMP signaling, phosphorylated-Mad and Trio. Interestingly, postsynaptic overexpression of the BMP ligand, Glass bottom boat, in <jats:italic>dnrx<\/jats:italic> mutants partially rescues the axonal transport defects but not the synapse undergrowth at the neuromuscular junctions. These data suggest that Dnrx and BMP signaling are involved in many diverse functions and that regulation of axonal MT organization and transport might be distinct from regulation of synaptic growth in <jats:italic>dnrx<\/jats:italic> mutants. Together, our work uncovers a novel function of <jats:italic>Drosophila<\/jats:italic> Neurexin and may provide insights into functions of Neurexins in vertebrates.<\/jats:p>","DOI":"10.1038\/s41598-018-35618-7","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T10:38:53Z","timestamp":1542710333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Coordinated Regulation of Axonal Microtubule Organization and Transport by Drosophila Neurexin and BMP Pathway"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-5197","authenticated-orcid":false,"given":"Swati","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeveen","family":"Riordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"35618_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0092-8674(00)80877-6","volume":"101","author":"P Scheiffele","year":"2000","unstructured":"Scheiffele, P., Fan, J., Choih, J., Fetter, R. & Serafini, T. 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