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M. by the Council of High Education."},{"name":"The Stanley Steyer Institute for Cancer Epidemiology and Research at Tel Aviv University, School of Public Health"},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["TA-MOU-01-M21-002"],"award-info":[{"award-number":["TA-MOU-01-M21-002"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DCURE Israel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Associations observed of <jats:italic>Helicobacter pylori<\/jats:italic> infection with haemoglobin levels are inconsistent. We examined associations of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. A cross-sectional study was undertaken among 654 Jewish and 937 Arab residents of Jerusalem, aged 25\u201378 years, randomly selected from Israel\u2019s national population registry in age-sex and population strata. Sera were tested for <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> IgG, cytotoxin\u2013associated gene A (CagA) antigen IgG antibody and PGs levels. Multivariable models were fitted to account for confounders. Participants with atrophic gastritis (PGI\u2009&lt;\u200930\u2009\u03bcg\/L or a PGI: PGII\u2009&lt;\u20093.0) had lower haemoglobin levels than those without: beta-coefficient \u22120.34 (95% CI \u22120.59, \u22120.09); in men \u22120.27 (95% CI \u22120.67, 0.12), and in women \u22120.43 (95% CI \u22120.74, \u22120.12). Lower haemoglobin levels were noted in persons with CagA antibody than in those <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> sero-negative or <jats:italic>H<\/jats:italic>. <jats:italic>pylor<\/jats:italic>i-CagA sero-negative: beta-coefficient \u22120.14 (95% CI \u22120.29, 0.01). Anaemia was more common among women and men with than without atrophic gastritis: adjusted OR 2.58 (95% CI 1.48, 4.48) and 1.52 (95% CI 0.59, 3.95), respectively. In conclusion, independent of known correlates, atrophic gastritis and apparently CagA sero-positivity, a marker of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> virulent strains, are associated with lower haemoglobin levels.<\/jats:p>","DOI":"10.1038\/s41598-018-35937-9","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:18:41Z","timestamp":1543429121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-7559","authenticated-orcid":false,"given":"Khitam","family":"Muhsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Sinnreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gany","family":"Beer-Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy D.","family":"Kark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"35937_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1523-5378.2008.00617.x","volume":"13","author":"K Muhsen","year":"2008","unstructured":"Muhsen, K. & Cohen, D. 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