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The main parasite ligands for cytoadhesion are members of the <jats:italic>P<\/jats:italic>. <jats:italic>falciparum<\/jats:italic> erythrocyte membrane protein 1 (PfEMP1) family. Interactions of different host receptor-ligand pairs may lead to various pathological outcomes, like placental or cerebral malaria. It has been shown previously that IE can bind integrin \u03b1V\u03b23. Using bead-immobilized PfEMP1 constructs, we have identified that the PFL2665c DBL\u03b41_D4 domain binds to \u03b1V\u03b23 and \u03b1V\u03b26. A parasite line expressing PFL2665c binds to surface-immobilized \u03b1V\u03b23 and \u03b1V\u03b26; both are RGD motif-binding integrins. Interactions can be inhibited by cyloRGDFV peptide, an antagonist of RGD-binding integrins. This is a first, to the best of our knowledge, implication of a specific PfEMP1 domain for binding to integrins. These host receptors have important physiological functions in endothelial and immune cells; therefore, these results will contribute to future studies and a better understanding, at the molecular level, of the physiological outcome of interactions between IE and integrin receptors on the surface of host cells.<\/jats:p>","DOI":"10.1038\/s41598-018-36071-2","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:06:30Z","timestamp":1544457990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Plasmodium falciparum infected erythrocytes can bind to host receptors integrins \u03b1V\u03b23 and \u03b1V\u03b26 through DBL\u03b41_D4 domain of PFL2665c PfEMP1 protein"],"prefix":"10.1038","volume":"8","author":[{"given":"Olga","family":"Chesnokov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Merritt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey O.","family":"Tcherniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta","family":"Milman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew V.","family":"Oleinikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"36071_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.tracli.2008.04.013","volume":"15","author":"AM Dondorp","year":"2008","unstructured":"Dondorp, A. 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