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We investigated intergenerational effects of maternal CM on DNA methylation and gene expression in<jats:italic>N<\/jats:italic>\u2009=\u2009113 mother-infant dyads shortly after parturition, additionally accounting for the role of the<jats:italic>FKBP5<\/jats:italic>rs1360780 genotype. Using mass array spectrometry, we assessed the DNA methylation of selected stress-response-associated genes (FK506 binding protein 51 [<jats:italic>FKBP5<\/jats:italic>], glucocorticoid receptor [<jats:italic>NR3C1<\/jats:italic>], corticotropin-releasing hormone receptor 1 [<jats:italic>CRHR1<\/jats:italic>]) in isolated immune cells from maternal blood and neonatal umbilical cord blood. In mothers, CM was associated with decreased levels of DNA methylation of<jats:italic>FKBP5<\/jats:italic>and<jats:italic>CRHR1<\/jats:italic>and increased<jats:italic>NR3C1<\/jats:italic>methylation, but not with changes in gene expression profiles. Rs1360780 moderated the<jats:italic>FKBP5<\/jats:italic>epigenetic CM-associated regulation profiles in a gene\u2009\u00d7\u2009environment interaction. In newborns, we found no evidence for any intergenerational transmission of CM-related methylation profiles for any of the investigated epigenetic sites. These findings support the hypothesis of a long-lasting impact of CM on the biological epigenetic regulation of stress-response mediators and suggest for the first time that these specific epigenetic patterns might not be directly transmitted to the next generation.<\/jats:p>","DOI":"10.1038\/s41598-018-36689-2","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T15:47:06Z","timestamp":1576684026000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach"],"prefix":"10.1038","volume":"9","author":[{"given":"Laura","family":"Ramo-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Boeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-0794","authenticated-orcid":false,"given":"Alexandra M.","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth B.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"G\u00fcndel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6erg M.","family":"Fegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karabatsiakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris-Tatjana","family":"Kolassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"36689_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.4088\/JCP.v65n0217","volume":"65","author":"SV Batten","year":"2004","unstructured":"Batten, S. 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