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Thirty-nine oesophageal SCC patients underwent DCE-MRI. Quantitative parameters including endothelial transfer constant (K<jats:sup>trans<\/jats:sup>), reflux rate (K<jats:sub>ep<\/jats:sub>), fractional extravascular extracellular space volume and fractional plasma volume, and semi-quantitative parameters including time to peak (TTP), max concentration, Max Slope and area under concentration-time curve of both oesophageal SCC and normal oesophagus were measured. Mann-Whitney U test revealed that K<jats:sup>trans<\/jats:sup> and K<jats:sub>ep<\/jats:sub> of oesophageal SCC were higher while TTP was shorter when compared to normal oesophagus (all <jats:italic>P<\/jats:italic>-values\u2009&lt;\u20090.05); and areas under receiver operating characteristic [ROC] curves displayed that K<jats:sub>ep<\/jats:sub> was superior to TTP or K<jats:sup>trans<\/jats:sup> for identifying oesophageal SCC (0.903 vs. 0.832 or 0.713). Mann-Whitney U test also demonstrated that K<jats:sub>ep<\/jats:sub> was higher and TTP was shorter in patients with lymphatic metastasis when compared to non-metastatic cancer patients (both <jats:italic>P<\/jats:italic>-values\u2009&lt;\u20090.05), and area under ROC curve also showed that TTP was superior to K<jats:sub>ep<\/jats:sub> for predicting lymphatic metastasis (0.696 vs. 0.659). In conclusion, the combination of quantitative and semi-quantitative parameters derived from DCE-MRI can aid in the identification of oesophageal SCC and lymphatic metastasis.<\/jats:p>","DOI":"10.1038\/s41598-018-36929-5","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T13:52:00Z","timestamp":1547041920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessing Microcirculation in Resectable Oesophageal Squamous Cell Carcinoma with Dynamic Contrast-enhanced MRI for Identifying Primary tumour and Lymphatic Metastasis"],"prefix":"10.1038","volume":"9","author":[{"given":"Yan-li","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"36929_CR1","doi-asserted-by":"publisher","first-page":"e359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay, J. et al. 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