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Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaints using a structured interview and depressive symptoms using a depression scale (CESD). Eighty-one patients were included (mean age 44.5\u2009\u00b1\u200914.3, 35% men, 74% classical). Subjective cognitive complaints were reported by 64% of all patients. OCI was present in thirteen patients (16%), predominantly in men with classical FD. Thirty-one patients (38%) had a high score (\u226516) on the CESD scale. Male sex (OR, 6.8; 95%CI, 1.6\u201339.8; p\u2009=\u20091.6\u2009*\u200910<jats:sup>\u22122<\/jats:sup>) and stroke (OR, 6.4; 95% CI, 1.1\u201341.0; p\u2009=\u20093.7\u2009*\u200910<jats:sup>\u22122<\/jats:sup>) were independently positively associated with OCI, and premorbid IQ (one IQ point increase: OR, 0.91; 95%CI, 0.82\u20130.98; p\u2009=\u20093.8\u2009*\u200910<jats:sup>\u22122<\/jats:sup>) was independently negatively associated with OCI. The CESD-score (one point increase: OR, 1.07; 95% CI, 1.02\u20131.13; p\u2009=\u20093.3\u2009*\u200910<jats:sup>\u22123<\/jats:sup>) and a history of depression (OR, 2.7; 95% CI, 1.1\u20137.3; p\u2009=\u20093.9\u2009*\u200910<jats:sup>\u22122<\/jats:sup>) were independently positively associated with subjective cognitive complaints. OCI is present in 16% of FD patients, warranting referral for neuropsychological assessment. Nevertheless, subjective cognitive complaints are related to depressive symptoms, emphasizing the importance of recognition and treatment of the latter.<\/jats:p>","DOI":"10.1038\/s41598-018-37320-0","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T07:47:16Z","timestamp":1547279236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of objective cognitive impairment and subjective cognitive complaints in patients with Fabry disease"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-7760","authenticated-orcid":false,"given":"Simon","family":"K\u00f6rver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert J.","family":"Geurtsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla E. 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Geurtsen, Maria G.F. Longo, Marjana R. Lima, Leonardo Vedolin and Marcel G.W. Dijkgraaf declare no competing interests. Carla E.M. Hollak declares that Sphinx (through AMC-research BV) is involved in pre-marketing studies with Sanofi-Genzyme, Protalix and Idorsia; she does not have any other financial relationship with pharmaceutical companies and reports no nonfinancial competing interests. Ivo N. van Schaik chairs a steering committee for CSL Behring and received departmental honoraria for serving on scientific advisory boards for CSL Behring and Baxter. All lecturing and consulting fees for INS were donated to the Stichting Klinische Neurologie, a local foundation that supports research in the field of neurological disorders. He reports no non-financial competing interests. Mirjam Langeveld declares that Sphinx (through AMC-research BV) is involved in pre-marketing studies with Sanofi- Genzyme, Protalix and Idorsia; she does not have any other financial relationship with pharmaceutical companies and reports no nonfinancial competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"188"}}