{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:58:05Z","timestamp":1723111085167},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["106-2314-B-006 -046"],"award-info":[{"award-number":["106-2314-B-006 -046"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis C (CHC) is strongly associated with risks of cardiovascular diseases. The impact of direct acting antiviral (DAA) therapy on central blood pressure remains unclear. This investigation evaluates changes in central blood pressure following DAA therapy. One hundred and two DAA-treated patients were prospectively enrolled. Lipid profiles and pulse wave analysis of brachial artery by cuff sphygmomanometry including augmentation index (AIx), a parameter of central artery stiffness, were evaluated. All of the 102 patients achieved sustained virological response (SVR12). Cholesterol and LDL significantly increased following SVR12. Along with lipid changes, significantly higher central diastolic pressure (78.2\u2009\u00b1\u200914.2\u2009mm Hg at baseline vs. 83.3\u2009\u00b1\u200913.9\u2009mm Hg at SVR12, p\u2009=\u20090.011) and AIx (33.0\u2009\u00b1\u200912.7% at baseline vs. 36.9\u2009\u00b1\u200912.9% at SVR12, p\u2009=\u20090.012) were only observed in the advanced fibrosis patients. Co-morbid diseases, including hypertension (33.4\u2009\u00b1\u200913.0% vs. 39.7\u2009\u00b1\u200912.6%, p\u2009=\u20090.003), abnormal waist circumference (33.8\u2009\u00b1\u200912.2% vs. 38.0\u2009\u00b1\u200913.2%, p\u2009=\u20090.027), and metabolic syndrome (34.5\u2009\u00b1\u200912.1% vs. 39.0\u2009\u00b1\u200911.2%, p\u2009=\u20090.043) were associated with augmented AIx upon SVR12. The augmented central artery stiffness following viral eradication by DAA therapy may raise the concern of short-term cardiovascular risk in CHC patients.<\/jats:p>","DOI":"10.1038\/s41598-018-37829-4","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T11:04:11Z","timestamp":1549364651000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Augmenting central arterial stiffness following eradication of HCV by direct acting antivirals in advanced fibrosis patients"],"prefix":"10.1038","volume":"9","author":[{"given":"Pin-Nan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Cheng","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chih","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Miin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"37829_CR1","doi-asserted-by":"publisher","first-page":"Suppl:S45","DOI":"10.1016\/j.jhep.2014.07.027","volume":"61","author":"E Gower","year":"2014","unstructured":"Gower, E. et al. Global epidemiology and genotype distribution of the hepatitis C virus infection. J. Hepatol. 61, Suppl:S45 (2014).","journal-title":"J. Hepatol."},{"key":"37829_CR2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/infdis\/jis385","volume":"206","author":"MH Lee","year":"2012","unstructured":"Lee, M. H. et al. Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study. J. Infect Dis. 206, 469\u2013477 (2012).","journal-title":"J. Infect Dis."},{"key":"37829_CR3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1136\/hrt.2003.018937","volume":"90","author":"C Vassalle","year":"2004","unstructured":"Vassalle, C. et al. Evidence for association between hepatitis C virus seropositivity and coronary artery disease. 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