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It is reasonable to expect that high levels of endogamy could be expressed in the skeleton of at least some Neandertal groups. Genetic studies indicate that the 13 individuals from the site of El Sidr\u00f3n, Spain, dated around 49,000\u2009bp, constituted a closely related kin group, making these Neandertals an appropriate case study for the observation of skeletal signs of inbreeding. We present the complete study of the 1674 identified skeletal specimens from El Sidr\u00f3n. Altogether, 17 congenital anomalies were observed (narrowing of the internal nasal fossa, retained deciduous canine, clefts of the first cervical vertebra, unilateral hypoplasia of the second cervical vertebra, clefting of the twelfth thoracic vertebra, diminutive thoracic or lumbar rib, os centrale carpi and bipartite scaphoid, tripartite patella, left foot anomaly and cuboid-navicular coalition), with at least four individuals presenting congenital conditions (clefts of the first cervical vertebra). At 49,000 years ago, the Neandertals from El Sidr\u00f3n, with genetic and skeletal evidence of inbreeding, could be representative of the beginning of the demographic collapse of this hominin phenotype.<\/jats:p>","DOI":"10.1038\/s41598-019-38571-1","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T13:55:25Z","timestamp":1549634125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Skeletal Anomalies in The Neandertal Family of El Sidr\u00f3n (Spain) Support A Role of Inbreeding in Neandertal Extinction"],"prefix":"10.1038","volume":"9","author":[{"given":"L.","family":"R\u00edos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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