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Our aim was to evaluate the impact of vitamin D-related polymorphisms and DHCR7 levels in the association between vitamin D deficiency and altered lipid profile in rheumatoid arthritis (RA). Serum 25(OH)-vitamin D, DHCR7 levels and vitamin D-related polymorphisms (VDR-rs2228570, CYP27A1-rs933994, CYP2R1-rs10741657 and DHCR7-rs12785878) were analyzed in 211 RA patients,94 controls and in a prospective cohort of 13 RA patients undergoing TNF\u03b1-blockade. Vitamin D was decreased in RA (p\u2009&lt;\u20090.001), correlated to HDL-cholesterol (r\u2009=\u20090.217, p\u2009&lt;\u20090.001) and total-\/HDL-cholesterol ratio (r\u2009=\u2009\u22120.227, p\u2009=\u20090.004). These correlations were restricted to the VDR-rs2228570 status. Vitamin D deficiency was associated with lower HDL-cholesterol (p\u2009=\u20090.028), higher tender (p\u2009=\u20090.005) and swollen (p\u2009=\u20090.002) joint counts, higher DAS28 (p\u2009=\u20090.018) and HAQ (p\u2009=\u20090.024) in AG\/AA-patients but not in their GG-counterparts. The associations among DHCR7, vitamin D and lipid profile followed a seasonal pattern, decreased DHCR7 (p\u2009=\u20090.008) and vitamin D (p\u2009&lt;\u20090.001) and increased total-cholesterol (p\u2009=\u20090.025) being found in winter\/spring. Increasing vitamin D upon TNF\u03b1-blockade paralleled RA clinical improvement (r\u2009=\u2009\u22120.610, p\u2009=\u20090.027) and DHCR7 elevation (r\u2009=\u20090.766, p\u2009=\u20090.002). In conclusion, vitamin D-related polymorphisms and DHCR7 are pivotal to understand the complex, seasonal associations between vitamin D and lipid profile in RA.<\/jats:p>","DOI":"10.1038\/s41598-019-38756-8","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T11:03:34Z","timestamp":1550833414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis"],"prefix":"10.1038","volume":"9","author":[{"given":"Javier","family":"Rodr\u00edguez-Carrio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Alperi-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Naves-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Dusso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Ballina-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge B.","family":"Cannata-And\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-7539","authenticated-orcid":false,"given":"Ana","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"38756_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/ki.2010.17","volume":"78","author":"A Verstuyf","year":"2010","unstructured":"Verstuyf, A., Carmeliet, G., Bouillon, R. & Mathieu, C. 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