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Adult daughters were grouped by maternal smoking levels during pregnancy: Non-smokers (58.5%), Light smokers (24.1%; smoked 1\u20139 cigarettes\/day), and Heavier smokers (17.4%; smoked \u226510 cigarettes\/day). Anthropometry was recorded on the adult daughters at approximately 26.0 years of age. Obesity was defined as BMI \u226530\u2009kg\/m<jats:sup>2<\/jats:sup>, and short stature as height more than two standard deviations below the population mean. Daughters whose mothers were Light and Heavier smokers in early pregnancy were 0.8\u2009cm and 1.0\u2009cm shorter, 2.3\u2009kg and 2.6\u2009kg heavier, and had BMI 0.84\u2009kg\/m<jats:sup>2<\/jats:sup> and 1.15\u2009kg\/m<jats:sup>2<\/jats:sup> greater, respectively, than daughters of Non-smokers. The adjusted relative risk of short stature was 55% higher in women born to smokers, irrespectively of smoking levels. Maternal smoking had a dose-dependent association with obesity risk, with offspring of Heavier smokers 61% and of Light smokers 37% more likely to be obese than the daughters of Non-smokers. In conclusion, maternal smoking in pregnancy was associated with an increased risk of short stature and obesity in their adult daughters.<\/jats:p>","DOI":"10.1038\/s41598-019-39006-7","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T11:03:52Z","timestamp":1552388632000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Maternal smoking early in pregnancy is associated with increased risk of short stature and obesity in adult daughters"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-4887","authenticated-orcid":false,"given":"Sarah E.","family":"Maessen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-9274","authenticated-orcid":false,"given":"Fredrik","family":"Ahlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-3364","authenticated-orcid":false,"given":"Maria","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-3682","authenticated-orcid":false,"given":"Wayne S.","family":"Cutfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-1956","authenticated-orcid":false,"given":"Jos\u00e9 G. 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