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Male and female mosquitoes also consume floral nectar that provides essential energy for flight and survival. Heretofore, nectar-foraging mosquitoes were thought to be guided solely by floral odorants. Using common tansies,<jats:italic>Tanacetum vulgare<\/jats:italic>L., northern house mosquitoes,<jats:italic>Culex pipiens<\/jats:italic>L., and yellow fever mosquitoes,<jats:italic>Aedes aegypti<\/jats:italic>(L.), we tested the hypothesis that the entire inflorescence Gestalt of olfactory, CO<jats:sub>2<\/jats:sub>and visual cues is more attractive to mosquitoes than floral odorants alone. In laboratory experiments, we demonstrated that visual and olfactory inflorescence cues in combination attract more mosquitoes than olfactory cues alone. We established that tansies become net producers of CO<jats:sub>2<\/jats:sub>after sunset, and that CO<jats:sub>2<\/jats:sub>enhances the attractiveness of a floral blend comprising 20 synthetic odorants of tansy inflorescences. This blend included nine odorants found in human headspace. The \u201chuman-odorant-blend\u201d attracted mosquitoes but was less effective than the entire 20-odorant floral blend. Our data support the hypothesis that the entire inflorescence Gestalt of olfactory, CO<jats:sub>2<\/jats:sub>and visual cues is more attractive to mosquitoes than floral odorants alone. Overlapping cues between plants and vertebrates support the previously postulated concept that haematophagy of mosquitoes may have arisen from phytophagy.<\/jats:p>","DOI":"10.1038\/s41598-019-39748-4","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T11:03:04Z","timestamp":1551956584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Multimodal floral cues guide mosquitoes to tansy inflorescences"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-5133","authenticated-orcid":false,"given":"Daniel A. 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