{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:21:43Z","timestamp":1790014903147,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The opportunistic pathogen <jats:italic>Mycobacterium ulcerans<\/jats:italic>, which is responsible for Buruli ulcer, synthesizes a series of plasmid-encoded macrolide exotoxins termed mycolactones. These toxins destabilize cell membranes and induce apoptosis-associated pleiotropic effects including tissue destruction, analgesic and anti-inflammatory effects. Despite its medical interest, <jats:italic>M. ulcerans<\/jats:italic> is primarily an environmental mycobacterium and the primary functions of mycolactones in the natural ecosystems are unknown. High throughput biochemical profiling findings suggested that <jats:italic>M. ulcerans<\/jats:italic> may interact with fungi. Here, we report that semi-purified and purified mycolactones significantly enhance spore germination of <jats:italic>Scedosporium apiospermum, Fusarium equiseti<\/jats:italic> and <jats:italic>Mucor circinelloides<\/jats:italic>; and that <jats:italic>M. ulcerans<\/jats:italic> mycolactones significantly attract colonies of <jats:italic>M. circinelloides<\/jats:italic> whereas no significant effect was observed on <jats:italic>S. apiospermum<\/jats:italic> and <jats:italic>F. equiseti<\/jats:italic>. These experimental results suggest that mycolactones exhibit a chemoattractant activity independent of their cytotoxicity. In natural ecosystems, <jats:italic>M. ulcerans<\/jats:italic> mycolactones may act as spore germination inducers and chemoattractants for some fungi, suggesting a novel role for this unique class of mycobacterial toxins in natural ecosystems.<\/jats:p>","DOI":"10.1038\/s41598-019-39927-3","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T11:05:03Z","timestamp":1551351903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mycobacterium ulcerans mycolactones-fungi crosstalking"],"prefix":"10.1038","volume":"9","author":[{"given":"Nassim","family":"Hammoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Cassagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-2244","authenticated-orcid":false,"given":"Nicholas","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-5276","authenticated-orcid":false,"given":"St\u00e9phane","family":"Ranque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Henrissat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Bouam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"39927_CR1","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3762\/bjoc.13.159","volume":"13","author":"M Gehringer","year":"2017","unstructured":"Gehringer, M. & Altmann, K. 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