{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:43:43Z","timestamp":1790016223970,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"Abstract<\/jats:title>\n \n Candida albicans<\/jats:italic>\n is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans\n Candida<\/jats:italic>\n species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the\n in vitro<\/jats:italic>\n susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was\n C<\/jats:italic>\n .\n albicans<\/jats:italic>\n (n\u2009=\u200993, 65%), followed by\n C<\/jats:italic>\n .\n glabrata<\/jats:italic>\n (n\u2009=\u200927, 19%) and\n C<\/jats:italic>\n .\n parapsilosis<\/jats:italic>\n (n\u2009=\u200915, 10%).\n C<\/jats:italic>\n .\n glabrata<\/jats:italic>\n was mostly found in elderly individuals, while\n C<\/jats:italic>\n .\n parapsilosis<\/jats:italic>\n was found mainly in young children (p\u2009=\u20090.008). Antifungal resistance was low in the\n Candida<\/jats:italic>\n species, except for reduced susceptibility to fluconazole among\n C<\/jats:italic>\n .\n glabrata<\/jats:italic>\n strains.\n C<\/jats:italic>\n .\n albicans<\/jats:italic>\n is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in\n Candida<\/jats:italic>\n species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in\n C<\/jats:italic>\n .\n glabrata<\/jats:italic>\n and\n C<\/jats:italic>\n .\n parapsilosis<\/jats:italic>\n , respectively.\n <\/jats:p>","DOI":"10.1038\/s41598-019-40280-8","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T06:04:07Z","timestamp":1551938647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia"],"prefix":"10.1038","volume":"9","author":[{"given":"Erika","family":"Lindberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Ataollahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Kondori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"40280_CR1","doi-asserted-by":"publisher","first-page":"e1003550","DOI":"10.1371\/journal.ppat.1003550","volume":"9","author":"N Papon","year":"2013","unstructured":"Papon, N., Courdavault, V., Clastre, M. & Bennett, R. 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