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This cross-sectional study included 566 paramedical workers at a university hospital in Korea. Dry eye symptoms were assessed using a 9-item questionnaire, and DED was defined as having 1 or more dry eye symptoms often or all the time. A survey including demographic data and potential risk factors of DED was also performed. Psychological stress was measured using stress VAS and perceived stress scale 4 (PSS-4) questionnaires. Of the 566 paramedical workers, 232 (35 male and 197 female) completed the survey. Prevalence of DED was 42.7% (99\/232). Univariate analysis revealed that female sex (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001), prolonged computer use (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003) and higher stress VAS (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and PSS-4 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009) scores had significant association with DED. In multivariate analysis, DED had significant association with female sex (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003) and stress VAS (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.013) after adjustment for sex, duration of computer use and stress VAS, and had significant association with female sex (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003) and durations of computer use (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.029) after adjustment for sex, duration of computer use and PSS-4 score. In conclusion, DED was prevalent among paramedical workers in Korea. Its risk increased among females and workers with increased psychological stress. Prolonged use of computer was possibly associated with DED.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-40539-0","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T06:04:07Z","timestamp":1551938647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Association between Dry Eye Disease and Psychological Stress among Paramedical Workers in Korea"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3620-1536","authenticated-orcid":false,"given":"Joon Young","family":"Hyon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Kyung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-239X","authenticated-orcid":false,"given":"Sang Beom","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"40539_CR1","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/S0161-6420(03)00262-8","volume":"110","author":"PY Lin","year":"2003","unstructured":"Lin, P. 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