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Although many studies show an association between the presence of periodontal bacteria and an overweight body-mass index (BMI; &gt;25\u2009kg\/m<jats:sup>2<\/jats:sup>), the relationship between body weight and the presence of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in the oral cavity has not been demonstrated. Herein, we analysed the relationship between <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in the oral cavity and systemic conditions, including the overweight BMI. Saliva specimens and extracted teeth were obtained from 87 subjects; the distribution of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> among these specimens was analysed with the polymerase chain reaction. Subjects with an overweight BMI exhibited significantly higher detection rates of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in saliva, compared with non-overweight subjects (BMI &lt;25\u2009kg\/m<jats:sup>2<\/jats:sup>) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A clinical history of digestive diseases was not associated with the presence of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in overweight subjects, whereas subjects with both severe dental caries and an overweight BMI showed a higher detection rate of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in saliva specimens, compared with other groups. These results suggest that the detection of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> in the oral cavity could be associated with the overweight BMI, which was predominant among subjects with severe dental caries.<\/jats:p>","DOI":"10.1038\/s41598-019-41166-5","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T21:35:28Z","timestamp":1553031328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Potential involvement of Helicobacter pylori from oral specimens in overweight body-mass index"],"prefix":"10.1038","volume":"9","author":[{"given":"Masakazu","family":"Hamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Ogaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaya","family":"Matayoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamami","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narikazu","family":"Uzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"41166_CR1","first-page":"42","volume":"9","author":"C Prasanthi","year":"2011","unstructured":"Prasanthi, C., Prasanthi, N., Manikiran, S. & Rao, N. 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