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In particular, previous genetic studies of patients with nephrotic syndrome identified mutations in\n                    <jats:italic>Nup107<\/jats:italic>\n                    that impaired the expression or the localization of its direct partner at nuclear pores, Nup133. In the present study, we characterized the zebrafish\n                    <jats:italic>nup133<\/jats:italic>\n                    orthologous gene and its expression pattern during larval development. Using a morpholino-mediated gene knockdown, we show that partial depletion of Nup133 in zebrafish larvae leads to the formation of kidney cysts, a phenotype that can be rescued by co-injection of wild type mRNA. Analysis of different markers for tubular and glomerular development shows that the overall kidney development is not affected by\n                    <jats:italic>nup133<\/jats:italic>\n                    knockdown. Likewise, no gross defect in nuclear pore complex assembly was observed in these\n                    <jats:italic>nup133<\/jats:italic>\n                    morphants. On the other hand,\n                    <jats:italic>nup133<\/jats:italic>\n                    downregulation results in proteinuria and moderate foot process effacement, mimicking some of the abnormalities typically featured by patients with nephrotic syndrome. These data indicate that\n                    <jats:italic>nup133<\/jats:italic>\n                    is a new gene required for proper glomerular structure and function in zebrafish.\n                  <\/jats:p>","DOI":"10.1038\/s41598-019-41202-4","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T07:03:45Z","timestamp":1553065425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish"],"prefix":"10.1038","volume":"9","author":[{"given":"Chiara","family":"Cianciolo Cosentino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Berto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Hari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Loffing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan C. 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