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The effect of inhibition on stimulus representation in less structured networks is not as clear. Here we exercise a biosynthetic approach in order to study the impacts of inhibition on stimulus representation in non-specialized network anatomy. Combining pharmacological manipulation, multisite electrical stimulation and recording from<jats:italic>ex-vivo<\/jats:italic>randomly rewired networks of cortical neurons, we quantified the effects of inhibition on response variability and stimulus discrimination at the population and single unit levels. We find that blocking inhibition quenches variability of responses evoked by repeated stimuli and enhances discrimination between stimuli that invade the network from different spatial loci. Enhanced stimulus discrimination is reserved for representation schemes that are based on temporal relation between spikes emitted in groups of neurons. Our data indicate that \u2013 under intact inhibition \u2013 the response to a given stimulus is a noisy version of the response evoked in the absence of inhibition. Spatial analysis suggests that the dispersion effect of inhibition is due to disruption of an otherwise coherent, wave-like propagation of activity.<\/jats:p>","DOI":"10.1038\/s41598-019-41220-2","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T11:12:55Z","timestamp":1553166775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibition increases response variability and reduces stimulus discrimination in random networks of cortical neurons"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-132X","authenticated-orcid":false,"given":"Netta","family":"Haroush","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Marom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"41220_CR1","doi-asserted-by":"publisher","unstructured":"Oster, G. 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