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Stability of radiomics features extracted from apparent diffusion coefficient (ADC)-maps is essential for reliable correlation with the underlying pathology and its clinical applications. Within a multicentre, multi-vendor trial we established a method to analyse radiomics features from ADC-maps of ovarian (n\u2009=\u200912), lung (n\u2009=\u200919), and colorectal liver metastasis (n\u2009=\u200930) cancer patients who underwent repeated (&lt;7 days) diffusion-weighted imaging at 1.5\u2009T and 3\u2009T. From these ADC-maps, 1322 features describing tumour shape, texture and intensity were retrospectively extracted and stable features were selected using the concordance correlation coefficient (CCC\u2009&gt;\u20090.85). Although some features were tissue- and\/or respiratory motion-specific, 122 features were stable for all tumour-entities. A large proportion of features were stable across different vendors and field strengths. By extracting stable phenotypic features, fitting-dimensionality is reduced and reliable prognostic models can be created, paving the way for clinical implementation of ADC-based radiomics.<\/jats:p>","DOI":"10.1038\/s41598-019-41344-5","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T14:46:13Z","timestamp":1553006773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial"],"prefix":"10.1038","volume":"9","author":[{"given":"Jurgen","family":"Peerlings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-5123","authenticated-orcid":false,"given":"Henry C.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Winfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalla","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard E.","family":"Van Beers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend","family":"Heerschap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-0383","authenticated-orcid":false,"given":"Alan","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim E.","family":"Wildberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix M.","family":"Mottaghy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita M.","family":"DeSouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"41344_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1148\/radiol.2016151631","volume":"281","author":"J Peerlings","year":"2016","unstructured":"Peerlings, J. et al. 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He received an advisor\/presenter fee and\/or reimbursement of travel costs\/external grant writing fee and\/or in kind manpower contribution from Oncoradiomics, BHV, Merck and Convert pharmaceuticals. Dr. Lambin has shares in the company Oncoradiomics SA and Convert pharmaceuticals SA and is co-inventor of two issued patents with royalties on radiomics (PCT\/NL2014\/050248, PCT\/NL2014\/050728) licensed to Oncoradiomics and one issue patent on mtDNA (PCT\/EP2014\/059089) licensed to ptTheragnostic\/DNAmito, three non-patentable invention (softwares) licensed to ptTheragnostic\/DNAmito, Oncoradiomics and Health Innovation Ventures. Dr. Woodruff has (minority) shares in the company Oncoradiomics. Dr. Wildberger reports institutional grants from Agfa, Bard, Bayer, GE, Optimed, Philips, Siemens and personal fees (Speaker\u2019s Bureau) from Bayer and Siemens outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"4800"}}