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We performed a genome-wide association meta-analysis on two Taiwanese cohorts consisting of 758 gout cases and 14166 controls of Han Chinese ancestry. All the participants were recruited from the Taiwan Biobank. For pathway analysis, we applied ICSNPathway (Identify candidate Causal SNPs and Pathways) analysis, and to investigate whether expression-associated genetic variants contribute to gout susceptibility, we systematically integrated lymphoblastoid expression quantitative trait loci (eQTL) and genome-wide association data of gout using <jats:italic>Sherlock<\/jats:italic>, a Bayesian statistical frame-work. In the meta-analysis, we found 4 SNPs that reached genome-wide statistical significance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095.0\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>). These SNPs are in or close to <jats:italic>ABCG2<\/jats:italic>, <jats:italic>PKD2<\/jats:italic> and <jats:italic>NUDT9<\/jats:italic> gene on chromosome 4. ICSNPathway analysis identified rs2231142 as the candidate causal SNP, and <jats:italic>ABCG2<\/jats:italic> as the candidate gene. Sherlcok analysis identified three genes, which were significantly associated with the risk of gout (<jats:italic>PKD2<\/jats:italic>, <jats:italic>NUTD9<\/jats:italic>, <jats:italic>and NAP1L5<\/jats:italic>). To conclude, we reported novel susceptible loci for gout that has not been previously addressed in the literature.<\/jats:p>","DOI":"10.1038\/s41598-019-41434-4","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T11:12:55Z","timestamp":1553166775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility"],"prefix":"10.1038","volume":"9","author":[{"given":"Meng-tse Gabriel","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chun","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyr-Chyr","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Chin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsiu","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenn-Hwai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Hao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"41434_CR1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/ard.2004.024091","volume":"64","author":"TR Mikuls","year":"2005","unstructured":"Mikuls, T. 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