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Genetic determinants of thyroid antibodies are still poorly known, especially as they were not studied in patients with thyroid diseases. We performed the first genome-wide association analysis of thyroid antibodies in 430 HT patients that may be considered as population extremes for thyroid antibodies distribution. We detected two suggestively associated genetic variants with TgAb, rs6972286 close to <jats:italic>ANKRD7<\/jats:italic> and <jats:italic>LSM8<\/jats:italic> (P\u2009=\u20092.34\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>) and rs756763 inside <jats:italic>CA10<\/jats:italic> (P\u2009=\u20096.05\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>), and one with TPOAb, rs12507813 positioned between <jats:italic>TRIM61<\/jats:italic> and <jats:italic>TRIM60<\/jats:italic> (P\u2009=\u20094.95\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>). Bivariate analysis resulted with three suggestively associated genetic variants that predispose to both antibodies: rs13190616 inside <jats:italic>RP11-138J23.1<\/jats:italic> (P\u2009=\u20092.01\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>), rs561030786 close to <jats:italic>DUBR<\/jats:italic> (P\u2009=\u20097.33\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>) and rs12713034 inside <jats:italic>FSHR<\/jats:italic> (P\u2009=\u20097.66\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>). All identified genomic regions have a substantial literature record of involvement with female-related traits, immune-mediated diseases and personality traits that are all characterized by increased thyroid antibody levels. Our findings demonstrate the existence of genetic overlap between thyroid autoimmunity in HT and different non-thyroid diseases characterized by the presence of thyroid antibodies. We also suggest that genetic variants that regulate antibody levels may differ between HT patients and individuals with normal thyroid function.<\/jats:p>","DOI":"10.1038\/s41598-019-41850-6","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:03:19Z","timestamp":1553857399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto\u2019s thyroiditis"],"prefix":"10.1038","volume":"9","author":[{"given":"Luka","family":"Br\u010di\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bari\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda","family":"Gra\u010dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesela","family":"Torlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Brekalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veselin","family":"\u0160krabi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatijana","family":"Zemunik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Barbali\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Punda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Boraska Perica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"41850_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","volume":"13","author":"P Caturegli","year":"2014","unstructured":"Caturegli, P., De Remigis, A. & Rose, N. 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