{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:34:48Z","timestamp":1762079688050,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100018528","name":"Korean Neurological Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018528","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). A \u201c50% responder\u201d analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.<\/jats:p>","DOI":"10.1038\/s41598-019-43065-1","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T10:03:25Z","timestamp":1556186605000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study"],"prefix":"10.1038","volume":"9","author":[{"given":"Byung-Su","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Wook","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Hee","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-1969","authenticated-orcid":false,"given":"Mi Ji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-4682","authenticated-orcid":false,"given":"Byung-Kun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyung","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Young","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Ju","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil-Wook","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungmi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Yeol","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Myun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heui-Soo","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Sang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"43065_CR1","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N","volume":"47","author":"R Burstein","year":"2000","unstructured":"Burstein, R., Yarnitsky, D., Goor-Aryeh, I., Ransil, B. J. & Bajwa, Z. H. An association between migraine and cutaneous allodynia. Annals of neurology 47, 614\u2013624 (2000).","journal-title":"Annals of neurology"},{"issue":"Suppl 1","key":"43065_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000085060","volume":"53","author":"PJ Goadsby","year":"2005","unstructured":"Goadsby, P. J. Migraine, allodynia, sensitisation and all of that. European neurology 53(Suppl 1), 10\u201316, https:\/\/doi.org\/10.1159\/000085060 (2005).","journal-title":"European neurology"},{"key":"43065_CR3","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1212\/01.WNL.0000137107.27585.F7","volume":"63","author":"NT Mathew","year":"2004","unstructured":"Mathew, N. T., Kailasam, J. & Seifert, T. Clinical recognition of allodynia in migraine. Neurology 63, 848\u2013852 (2004).","journal-title":"Neurology"},{"key":"43065_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ana.21211","volume":"63","author":"RB Lipton","year":"2008","unstructured":"Lipton, R. B. et al. Cutaneous allodynia in the migraine population. Annals of neurology 63, 148\u2013158, https:\/\/doi.org\/10.1002\/ana.21211 (2008).","journal-title":"Annals of neurology"},{"issue":"Pt 8","key":"43065_CR5","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1093\/brain\/123.8.1703","volume":"123","author":"R Burstein","year":"2000","unstructured":"Burstein, R., Cutrer, M. F. & Yarnitsky, D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain: a journal of neurology 123(Pt 8), 1703\u20131709 (2000).","journal-title":"Brain: a journal of neurology"},{"issue":"Suppl 2","key":"43065_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1468-2982.2004.00892.x","volume":"24","author":"SD Silberstein","year":"2004","unstructured":"Silberstein, S. D. Migraine pathophysiology and its clinical implications. Cephalalgia: an international journal of headache 24(Suppl 2), 2\u20137, https:\/\/doi.org\/10.1111\/j.1468-2982.2004.00892.x (2004).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/ana.10786","volume":"55","author":"R Burstein","year":"2004","unstructured":"Burstein, R., Collins, B. & Jakubowski, M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Annals of neurology 55, 19\u201326, https:\/\/doi.org\/10.1002\/ana.10786 (2004).","journal-title":"Annals of neurology"},{"key":"43065_CR8","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1212\/01.wnl.0000310645.31020.b1","volume":"70","author":"ME Bigal","year":"2008","unstructured":"Bigal, M. E. et al. Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology 70, 1525\u20131533, https:\/\/doi.org\/10.1212\/01.wnl.0000310645.31020.b1 (2008).","journal-title":"Neurology"},{"key":"43065_CR9","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1093\/brain\/awt251","volume":"136","author":"MA Louter","year":"2013","unstructured":"Louter, M. A. et al. Cutaneous allodynia as a predictor of migraine chronification. Brain: a journal of neurology 136, 3489\u20133496, https:\/\/doi.org\/10.1093\/brain\/awt251 (2013).","journal-title":"Brain: a journal of neurology"},{"key":"43065_CR10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10194-012-0479-9","volume":"13","author":"S Ashina","year":"2012","unstructured":"Ashina, S. et al. Depression and risk of transformation of episodic to chronic migraine. The journal of headache and pain 13, 615\u2013624, https:\/\/doi.org\/10.1007\/s10194-012-0479-9 (2012).","journal-title":"The journal of headache and pain"},{"issue":"Suppl 2","key":"43065_CR11","first-page":"ii19","volume":"72","author":"MS Matharu","year":"2002","unstructured":"Matharu, M. S. & Goadsby, P. J. Trigeminal autonomic cephalgias. Journal of neurology, neurosurgery, and psychiatry 72(Suppl 2), ii19\u2013ii26 (2002).","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"key":"43065_CR12","doi-asserted-by":"publisher","first-page":"e2407","DOI":"10.1136\/bmj.e2407","volume":"344","author":"AD Nesbitt","year":"2012","unstructured":"Nesbitt, A. D. & Goadsby, P. J. Cluster headache. BMJ (Clinical research ed.) 344, e2407, https:\/\/doi.org\/10.1136\/bmj.e2407 (2012).","journal-title":"BMJ (Clinical research ed.)"},{"key":"43065_CR13","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/j.1526-4610.2004.04195.x","volume":"44","author":"A Ashkenazi","year":"2004","unstructured":"Ashkenazi, A. & Young, W. B. Dynamic mechanical (brush) allodynia in cluster headache. Headache 44, 1010\u20131012, https:\/\/doi.org\/10.1111\/j.1526-4610.2004.04195.x (2004).","journal-title":"Headache"},{"key":"43065_CR14","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/j.1526-4610.2005.05180.x","volume":"45","author":"WB Young","year":"2005","unstructured":"Young, W. B., Richardson, E. S. & Shukla, P. Brush allodynia in hospitalized headache patients. Headache 45, 999\u20131003, https:\/\/doi.org\/10.1111\/j.1526-4610.2005.05180.x (2005).","journal-title":"Headache"},{"key":"43065_CR15","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1111\/j.1468-2982.2006.01134.x","volume":"26","author":"J Ladda","year":"2006","unstructured":"Ladda, J., Straube, A., Forderreuther, S., Krause, P. & Eggert, T. Quantitative sensory testing in cluster headache: increased sensory thresholds. Cephalalgia: an international journal of headache 26, 1043\u20131050, https:\/\/doi.org\/10.1111\/j.1468-2982.2006.01134.x (2006).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR16","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1526-4610.2008.01187.x","volume":"49","author":"G Huber","year":"2009","unstructured":"Huber, G. & Lampl, C. Oxygen therapy influences episodic cluster headache and related cutaneous brush and cold allodynia. Headache 49, 134\u2013136, https:\/\/doi.org\/10.1111\/j.1526-4610.2008.01187.x (2009).","journal-title":"Headache"},{"key":"43065_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10194-009-0124-4","volume":"10","author":"MJ Marmura","year":"2009","unstructured":"Marmura, M. J., Abbas, M. & Ashkenazi, A. Dynamic mechanical (brush) allodynia in cluster headache: a prevalence study in a tertiary headache clinic. The journal of headache and pain 10, 255\u2013258, https:\/\/doi.org\/10.1007\/s10194-009-0124-4 (2009).","journal-title":"The journal of headache and pain"},{"key":"43065_CR18","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/j.1468-2982.2008.01794.x","volume":"29","author":"F Riederer","year":"2009","unstructured":"Riederer, F., Selekler, H. M., Sandor, P. S. & Wober, C. Cutaneous allodynia during cluster headache attacks. Cephalalgia: an international journal of headache 29, 796\u2013798, https:\/\/doi.org\/10.1111\/j.1468-2982.2008.01794.x (2009).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR19","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1097\/j.pain.0000000000000891","volume":"158","author":"LA Wilbrink","year":"2017","unstructured":"Wilbrink, L. A. et al. Allodynia in cluster headache. Pain 158, 1113\u20131117, https:\/\/doi.org\/10.1097\/j.pain.0000000000000891 (2017).","journal-title":"Pain"},{"key":"43065_CR20","doi-asserted-by":"publisher","unstructured":"The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia: an international journal of headache 33, 629\u2013808, https:\/\/doi.org\/10.1177\/0333102413485658 (2013).","DOI":"10.1177\/0333102413485658"},{"key":"43065_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1526-4610.2011.02024.x","volume":"52","author":"MS Robbins","year":"2012","unstructured":"Robbins, M. S. et al. Depression and anxiety in episodic and chronic cluster headache: a pilot study. Headache 52, 600\u2013611, https:\/\/doi.org\/10.1111\/j.1526-4610.2011.02024.x (2012).","journal-title":"Headache"},{"key":"43065_CR22","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1177\/0333102417731348","volume":"38","author":"KL Haywood","year":"2018","unstructured":"Haywood, K. L. et al. Assessing the impact of headaches and the outcomes of treatment: A systematic review of patient-reported outcome measures (PROMs). Cephalalgia: an international journal of headache 38, 1374\u20131386, https:\/\/doi.org\/10.1177\/0333102417731348 (2018).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR23","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1126\/science.288.5472.1769","volume":"288","author":"DD Price","year":"2000","unstructured":"Price, D. D. Psychological and neural mechanisms of the affective dimension of pain. Science (New York, N.Y.) 288, 1769\u20131772 (2000).","journal-title":"Science (New York, N.Y.)"},{"key":"43065_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10548-005-7898-8","volume":"18","author":"T Ushida","year":"2005","unstructured":"Ushida, T. et al. Virtual pain stimulation of allodynia patients activates cortical representation of pain and emotions: a functional MRI study. Brain topography 18, 27\u201335, https:\/\/doi.org\/10.1007\/s10548-005-7898-8 (2005).","journal-title":"Brain topography"},{"key":"43065_CR25","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1212\/01.wnl.0000168259.94991.8a","volume":"65","author":"JD Berry","year":"2005","unstructured":"Berry, J. D. & Petersen, K. L. A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. Neurology 65, 444\u2013447, https:\/\/doi.org\/10.1212\/01.wnl.0000168259.94991.8a (2005).","journal-title":"Neurology"},{"issue":"Pt 3","key":"43065_CR26","first-page":"427","volume":"117","author":"PJ Goadsby","year":"1994","unstructured":"Goadsby, P. J. & Edvinsson, L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain: a journal of neurology 117(Pt 3), 427\u2013434 (1994).","journal-title":"Neuropeptide changes and effects of acute attacks therapies. Brain: a journal of neurology"},{"key":"43065_CR27","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1212\/WNL.57.10.1817","volume":"57","author":"N Witting","year":"2001","unstructured":"Witting, N. et al. Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 57, 1817\u20131824 (2001).","journal-title":"Neurology"},{"key":"43065_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0896-6273(02)00767-5","volume":"35","author":"J Lorenz","year":"2002","unstructured":"Lorenz, J. et al. A unique representation of heat allodynia in the human brain. Neuron 35, 383\u2013393 (2002).","journal-title":"Neuron"},{"key":"43065_CR29","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1468-2982.2003.00721.x","volume":"24","author":"KH Lin","year":"2004","unstructured":"Lin, K. H. et al. Cluster headache in the Taiwanese\u2013a clinic-based study. Cephalalgia: an international journal of headache 24, 631\u2013638, https:\/\/doi.org\/10.1111\/j.1468-2982.2003.00721.x (2004).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR30","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1177\/0333102410391486","volume":"31","author":"N Imai","year":"2011","unstructured":"Imai, N. et al. Clinical profile of cluster headaches in Japan: low prevalence of chronic cluster headache, and uncoupling of sense and behaviour of restlessness. Cephalalgia: an international journal of headache 31, 628\u2013633, https:\/\/doi.org\/10.1177\/0333102410391486 (2011).","journal-title":"Cephalalgia: an international journal of headache"},{"key":"43065_CR31","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3346\/jkms.2017.32.3.502","volume":"32","author":"HS Moon","year":"2017","unstructured":"Moon, H. S. et al. Clinical Features of Cluster Headache Patients in Korea. Journal of Korean medical science 32, 502\u2013506, https:\/\/doi.org\/10.3346\/jkms.2017.32.3.502 (2017).","journal-title":"Journal of Korean medical science"},{"key":"43065_CR32","doi-asserted-by":"publisher","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia: an international journal of headache 38, 1\u2013211, https:\/\/doi.org\/10.1177\/0333102417738202 (2018).","DOI":"10.1177\/0333102417738202"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-43065-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-43065-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-43065-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T08:55:53Z","timestamp":1671267353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-43065-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["43065"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-43065-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2019,4,25]]},"assertion":[{"value":"24 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"6548"}}